Genetic Risk Score May Identify Children at Risk for Impaired Fasting Glucose

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Genetic score and clinical risk factors can identify children at high risk for impaired fasting glucose.
Genetic score and clinical risk factors can identify children at high risk for impaired fasting glucose.

(HealthDay News) — The addition of genetic risk variant data to conventional childhood risk factors improves risk assessment of impaired fasting glucose (IFG) and type 2 diabetes in adulthood, according to a study published in Diabetes Care.

Niina Pitkänen, PhD, from the University of Turku in Finland, and colleagues analyzed an association of a weighted genetic risk score (GRS) based on 73 risk variants with IFG and type 2 diabetes in 2298 participants of the Cardiovascular Risk in Young Finns Study. Participants were followed from childhood to adulthood for 24 to 31 years.

Overall, 21.8% and 3.4% of participants had IFG or type 2 diabetes in adulthood, respectively. The researchers found that weighted GRS correlated with increased risk for IFG and type 2 diabetes after adjustment for multiple confounding variables (odds ratios, 1.64 and 2.22, respectively, per unit increase in the weighted GRS). 

Model discrimination and reclassification properties were improved with incorporation of wGRS into pediatric risk models. For IFG, combined IFG and type 2 diabetes outcome, and type 2 diabetes, the area under the receiver operating curve improved (P=.015, .007, .158, respectively). For all outcomes, the net reclassification improvement and integrated discrimination improvement were significant.

"A multifactorial approach combining genetic and clinical risk factors may be useful in identifying children at high risk for adult IFG and type 2 diabetes," the researchers wrote.

Reference

  1. Pitkänen N, Juonala M, Rönnemaa T, et al. Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study. Diabetes Care. 2016. doi:10.2337/dc16-0167.
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