Drug Combination Reduces HbA1c More Than Monotherapy

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Empagliflozin plus metformine reduced HbA1c more than either treatment alone in type 2 diabetes.
Empagliflozin plus metformine reduced HbA1c more than either treatment alone in type 2 diabetes.

(HealthDay News) -- Twenty-four weeks of empagliflozin plus metformin correlates with a significantly greater reduction in HbA1c compared with once-daily empagliflozin or twice-daily metformin, according to a study published in Diabetes Care.

Samy Hadjadj, MD, PhD, from the Centre Hospitalier Universitaire Poitiers in France, and colleagues randomly assigned 1364 drug-naive patients with type 2 diabetes to empagliflozin plus metformin, empagliflozin, or metformin for 24 weeks. The authors examined the change from baseline in HbA1c at week 24.

At week 24, the researchers observed reductions in HbA1c of −1.9% to −2.1% with empagliflozin plus metformin twice-daily regimens; −1.4% with empagliflozin once-daily regimens; and −1.2% to −1.8% with metformin twice-daily regimens. Empagliflozin plus metformin twice-daily regimens correlated with significantly greater reductions in HbA1c than for empagliflozin once-daily regimens (P<.001) and metformin twice-daily regimens (P<.01). Compared with metformin twice-daily regimens, empagliflozin plus metformin twice-daily regimens correlated with significantly greater weight loss at week 24 (all P<.001). Across the groups, adverse event rates were similar.

"Initial combinations of empagliflozin plus metformin for 24 weeks significantly reduced HbA1c vs empagliflozin once daily and metformin twice daily, without increased hypoglycemia, reduced weight vs metformin twice daily, and were well tolerated," the researchers wrote.

Disclosures: Several authors disclosed financial ties to pharmaceutical companies, including Boehringer Ingelheim and Eli Lilly, which manufacture empagliflozin and funded the study.

Reference

  1. Hadjadj S, Rosenstock J, Meinicke T, Woerle HJ, Broedl UC. Initial Combination of Empagliflozin and Metformin in Patients With Type 2 Diabetes. Diabetes Care. 2016. doi:10.2337/dc16-0522.
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