Diabetes Increases Cancer Incidence, Mortality
the Endocrinology Advisor take:
Patients with type 1 and type 2 diabetes have an increased risk of developing and dying from cancer, according to a study published in Diabetes Care.
Patients with type 2 diabetes in particular had an increased risk of developing almost every type of cancer compared to the general population, reported Jonathan E. Shaw, MD, of the Baker IDI Heart and Diabetes Institute in Melbourne, and colleagues.
Previous evidence has suggested that patients with type 2 diabetes have an increased risk of developing particular cancers. The researchers wanted to determine the risk of site-specific cancer for people with type 1 and type 2 diabetes compared with the general population.
The study included 953,382 participants from a National Diabetes Registry between 1997 and 2008, who were linked to national death and cancer registries in Australia.
The researchers found that people with type 1 diabetes had an increased risk for cancer of the pancreas, liver, and esophagus. Females with type 1 diabetes also had an increased risk for colorectal, stomach, thyroid, brain, lung, endometrial, and ovarian cancers.
Patients with type 1 diabetes had increased rates of mortality from pancreas, liver, kidney (males only), brain (females only), and endometrium cancers as well as non-Hodgkin’s lymphoma.
For patients with type 2 diabetes, the risk of developing almost all cancers was significantly higher than the general population, especially for the liver and pancreas. They also had an increased rate of mortality for liver, pancreas, and kidney cancers in addition to Hodkin’s lymphoma. Females with type 2 diabetes had additional increased rates of mortality for gallbladder and stomach cancers as well as non-Hodgkin’s lymphoma.
Both patients with type 1 and type 2 diabetes had lower risks of developing melanoma and prostate cancer than the general population.
Because the incidence and mortality of cancers is higher in patients with diabetes, the researchers emphasized the importance of screening these patients for cancer.
Patients with diabetes have an increased risk of developing cancer compared with the general population.
OBJECTIVE Evidence indicates an increased risk of certain cancers among people with type 2 diabetes. Evidence for rarer cancers and for type 1 diabetes is limited. We explored the excess risk of site-specific cancer incidence and mortality among people with type 1 and type 2 diabetes, compared with the general Australian population.
CONCLUSIONS Type 1 and type 2 diabetes are associated with an excess risk of incidence and mortality for overall and a number of site-specific cancers, and this is only partially explained by bias. We suggest that screening for cancers in diabetic patients is important.
Endocrinology Advisor Articles
- Effect of HbA1c and Perioperative Glucose on Postoperative Mortality
- GLP-1 Agonists Superior to DPP-4 Inhibitors for Reducing HbA1c, Weight in T2D
- Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome
- Case for Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes
- Telemedicine Expands Access to Rural, Low-Income, Isolated Communities
- American College of Physicians Releases 4 Guidelines for HbA1c Targets in T2D
- Dyslipidemia Drug Indications
- No Difference in Weight Loss Outcomes With Low-Fat vs Low-Carbohydrate Diet
- Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture
- Pioglitazone May Reduce Cardiovascular, Noncardiovascular Mortality in T2D
- Bariatric Surgery Underused in Adolescents With Severe Obesity
- Once-Daily Oral Contraceptive for Men Shows Promise
- MiniMed 670G System Improves Glycemic Outcomes in Children With T1D
- Semaglutide May Be Useful for Treating Obesity in People Without Diabetes
- Low Sperm Count Linked to Poor Metabolic, Cardiovascular, Bone Health