Changing Trends in the Use of Glucose-Lowering Drugs for Type 2 Diabetes

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Over 8 years, researchers noted changes in the use of glucose-lowering drugs for type 2 diabetes.
Over 8 years, researchers noted changes in the use of glucose-lowering drugs for type 2 diabetes.

HealthDay News -- For patients with type 2 diabetes, the use of glucose-lowering drugs changed from 2006 to 2013, but glycemic control has not changed, according to a study published in Diabetes Care.

Kasia J. Lipska, MD, from the Yale School of Medicine in New Haven, Connecticut, and colleagues used claims data from 1.66 million privately insured and Medicare Advantage patients with type 2 diabetes to examine use of glucose-lowering medications, glycemic control, and the rate of severe hypoglycemia. The proportions were calculated overall and stratified by age and number of comorbidities.

The researchers observed an increase in use of metformin, dipeptidyl peptidase-4 inhibitors, and insulin, and a decline in use of sulfonylureas and thiazolidinediones, from 2006 to 2013 (all P <.001). There was a decline in the proportion of patients with HbA1c lower than 7% and an increase in the proportion with HbA1c of 9% or higher (both P <.001). 

There was variation in glycemic control based on age; in 2013, there was poor control among 23.3% of the youngest and 6.3% of the oldest patients. The overall severe hypoglycemia rate remained stable (1.3 per 100 person-years; P =.72).

"During the recent 8-year period, the use of glucose-lowering drugs has changed dramatically among patients with type 2 diabetes," the researchers wrote. "Overall glycemic control has not improved and remains poor among nearly a quarter of the youngest patients."

Disclosures: Several researchers disclosed relationships with one or more of the following: Medtronic, Johnson & Johnson (Janssen), Blue Cross Blue Shield Association, iodine.com, Boehringer Ingelheim, Merck, AstraZeneca, Sanofi, Daiichi Sankyo, Novo Nordisk, Takeda, and UnitedHealthcare.

Reference

  1. Lipska KJ, Yao X, Herrin J, et al. Trends in drug utilization, glycemic control, and rates of severe hypoglycemia, 2006–2013 [published online September 22, 2016]. Diabetes Care. doi:10.2337/dc16-0985.
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