Type 2 Diabetes Archive
The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.
IPITA and EPITA held a workshop to develop consensus for a joint statement on the definition of function and failure of current and future forms of β-cell replacement therapy.
Changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet
For women with previous gestational diabetes, lactation is associated with reduced risk of type 2 diabetes, although there is no benefit for long-term lactation.
The patient, a 50-year old male, presented to the emergency department with palpitations and complaints of nausea, retching and diarrhea which he said started after he squeezed a nodule on his thigh.
Antidiabetic agents for the treatment of diabetes including maintenance and max doses.
Compared with standard care, noninvasive coronary artery disease screening reduced cardiac events by 27% in individuals with asymptomatic diabetes. Results justify larger, appropriately powered trials to potentially revisit current recommendations.
Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.
Open-flame and/or high-temperature cooking methods (such as grilling/barbecuing, broiling, or roasting) to prepare chicken and red meat are associated with an increased risk of type 2 diabetes.
Results suggest that first trimester use of insulin analogues does not increase the risk for a congenital anomaly in women with diabetes compared with the use of human insulin.
Among a large US cohort of patients treated for HCV, patients who achieved sustained virologic response demonstrated a substantially lower risk for development of type 2 diabetes than patients with treatment failure.
IDegLira provides an efficacious intensification option with noninferior glycemic control vs basal-bolus in patients with type 2 diabetes receiving 20 to 50 units of basal insulin with no renal impairment and HbA1c levels of 7% to 10%.
The Food and Drug Administration (FDA) has issued a discontinuation notice for Bydureon (exenatide extended-release; AstraZeneca) for injectable suspension Single Dose Trays.
Study provides stronger epidemiological evidence for obesity as a risk factor for diabetic polyneuropathy.
The DURATION-7 study examined the effect of Bydureon or placebo as add-on therapy to insulin glargine, with or without metformin, in adults with T2D.
The study adds insight to the extent of both racial and regional variations in the prevalence of chronic kidney disease while calling attention to the magnitude of this disease in patients prior to being diagnosed with diabetes.
A recent study evaluated the effects of SGLT-2i and other glucose-lowering drugs on cardiovascular event outcomes in patients with type 2 diabetes from 6 countries in 3 world regions.
Given the high risk for metabolic disorder and type 2 diabetes, clinicians should select psychotropic medications carefully and monitor metabolic conditions regularly in their patients with serious mental illness.
The new analysis focuses on the remaining 4960 patients, who had prediabetes at the start of the trial.
Food insecurity screening and interventions may help improve glycemic control for vulnerable patients.
Study provided evidence of significant differences in median serum concentrations of circulating adipose-related inflammatory biomarkers across the main diabetes types.
The Tresiba label was updated to reflect safety outcomes from the DEVOTE trial.
Sanofi announced that the Food and Drug Administration (FDA) has approved Toujeo (insulin glargine 300 Units/mL) Max SoloStar, a long-acting insulin pen that holds 900 Units of Toujeo and provides up to 160 Units/mL per injection.
Dipeptidyl peptidase-4 inhibitors are associated with increased risk of inflammatory bowel disease among patients with type 2 diabetes.
Researchers compared glycemic control in cohorts of severely obese adolescents with type 2 diabetes undergoing medical and surgical interventions.
Statins were associated with a reduction in mortality but there was no significant difference in the composite end point with fenofibrates alone or in combination with statins.
In patients with type 2 diabetes and heart failure, primary prevention with aspirin reduced all-cause mortality but increased nonfatal myocardial infarction and stroke.
In people with obesity and type 2 diabetes, a meal schedule that includes a high-energy breakfast promotes weight loss, improves diabetes, and decreases the need for insulin.
Perioperative glucose control may be more important than preoperative HbA1c in predicting 30-day postoperative mortality.
New research suggests that there are separate pathways for the development of type 2 diabetes and obesity in patients with serious mental illness and demonstrate that there are important effects associated with sex and race or ethnicity.
Changes in weight influence the risk of diabetes, with lower risk of diabetes for obese individuals who lose weight vs stable obesity.
Researchers conducted an analysis to better understand what proportion of adults engage in lifestyle behaviors known the reduce the risk of type 2 diabetes.
Researchers modeled the absolute and gross domestic product-relative economic burden of diabetes in individuals aged 20 to 79 years using epidemiological and demographic data as well as recent GDP forecasts for 180 countries.
Clinicians should reevaluate HbA1c levels and revise treatment strategies on the basis of changes in the balance of benefits and harms due to changed costs of care and patient preferences, general health, and life expectancy.
Microvascular decompression for trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia was found to be a largely safe procedure, but patients with diabetes or obesity are an increased risk for reoperation within 30 days.
Placebo-treated patients with diabetes commonly experienced a reduction in HbA1c, more markedly in augmented vs exclusively placebo-controlled treatment arms.
Plasma leptin levels are independently associated with sleep quality in obese patients with type 2 diabetes, but not in those who are not obese.
Study examined the association between individual antidiabetic sulfonylureas and outpatient-originating sudden cardiac arrest and ventricular arrhythmia.
In women with type 2 diabetes, no evidence was found of an association between the use of metformin or statins and the incidence of ovarian cancer.
Women, not men, with T2D had an increased obesity-related standardized cancer incidence compared with women in the general population as early as 5 years before diabetes diagnosis.
The method of individualized treatment effect prediction of fenofibrate on major cardiovascular events risk reduction in T2D can be used to guide clinical decision-making.
High-quality studies are needed to determine whether tight intrapartum glycemic control is superior to more relaxed glycemic targets intrapartum for women with diabetes in pregnancy.
Researchers compared the effects of combined metformin and COX-2 inhibitor therapy vs COX-2 therapy alone on joint replacement surgery rates.
Study assessed the efficacy and safety of insulin glargine 300 U/mL vs glargine 100 U/mL with and without concomitant DPP-4 inhibitor use in people with type 2 diabetes.
Study examined the effect of age at diagnosis of type 2 diabetes on the risk of all-cause and cause-specific mortality over 15 years.
After induction short-term intensive insulin therapy, metformin is superior to intermittent IIT for maintaining beta-cell function and glycemic control over 2 years.
For obese adults with type 2 diabetes, Roux-en-Y gastric bypass surgery is associated with greater weight loss, lower HbA1c, and reduced cardiovascular risk compared with intensive medical diabetes and weight management.
The novel findings in this study suggest that patients with type 2 diabetes have a significantly reduced risk for short-term mortality after hospitalization for aortic aneurysm compared with population-based control subjects.
Eating speed can affect changes in obesity, body mass index, and waist circumference in patients with type 2 diabetes.
A recent study examined mortality trends in adults with diabetes and assessed albumin-to-creatinine ratios and estimated glomerular filtration rates.
Risk of developing type 2 diabetes is associated with subtle elevations of glucose and lipids more than 20 years before diagnosis.
Diabetes care can be improved with enhanced communication between providers and patients and improved communication between members of the primary care team.
This is the first study to have validated a metformin dose adjustment as a function of the estimated glomerular filtration rate in patients with type 2 diabetes and chronic kidney disease.
The bidirectional relationship between severe hypoglycemic events and cardiovascular outcomes suggests that there may be a common "frail" type 2 diabetes phenotype of patients who are susceptible to both of these events.
Higher rates of operative delivery and falling gestational age at delivery suggest that this is either reflected by, or despite, increasing obstetric intervention.
Two recently-approved diabetes treatments, a semaglutide injection and an insuline aspart injection, are now available in pharmacies across the United States.
Patients with type 2 diabetes who received once-weekly semaglutide had statistically greater reductions in HbA1c and body weight compared with those treated with dulaglutide.
ADA's recommendations reflect the latest advances in evidence-based research to improve care for millions of people with diabetes.
Study assessed the relationship of fasting neuropeptide Y with insulin resistance, β-cell function, and glucagon-like peptide-1 secretion in nonobese female patients with chronic migraine.
Stricter glycemic control during short-term intensive insulin therapy for newly diagnosed type 2 diabetes patients is associated with a higher likelihood of remission at 1 year.
Duration of Prediabetes, Diabetes Independently Associated With Subclinical Atherosclerosis, Cardiac Dysfunction
Data emphasize the importance of early identification and management of those at risk for diabetes and prediabetes in order to limit exposure to the adverse cardiovascular effects of a longer duration of these conditions.
Higher risks for adverse pregnancy outcomes observed in pregnant women taking metformin for pregestational diabetes are not a result of metformin, but diabetes.
A single dose of the dipeptidyl peptidase-4 inhibitor sitagliptin is associated with increased standardized insulin secretion, with no impact on β-cell glucose sensitivity.
There is considerable variation in adherence across medication classes for the treatment of type 2 diabetes, including sulfonylureas, thiazolidinediones, and metformin.
Clinical guidelines should include postpartum screening and management for all cardiovascular risk factors in women diagnosed with gestational diabetes and not restrict it to diabetes.
The initial decision to discontinue Tanzeum was announced in August 2017 due to limited prescribing of the drug and not because of safety concerns.
Living kidney donors have no increased risks for all-cause mortality, cardiovascular disease, hypertension, type 2 diabetes, or adverse psychological health outcomes.
Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.
Balance training interventions (supervised and unsupervised) led to significant improvements in a number of physiological measures, ultimately reflected in a decline in fall risk for older adults with T2D.
Patients with type 2 diabetes treated with sulfonylureas may be at a higher risk of contracting tuberculosis, compared with patients treated with metformin.
In patients with an acute coronary syndrome and LDL-C >50 mg/dL, healthcare providers should consider adding ezetimibe to statin therapy to reduce the risk of cardiovascular events.
Patients with diabetes had higher rates for all 19 infection categories with the highest incidence rate ratios seen for bone and joint infections, sepsis, and cellulitis.
Among patients with type 2 diabetes initiating antidiabetes drugs, first-line use of metformin has increased since 2005.
Differences in traditional modifiable diabetes risk factors between black and white individuals may contribute to the racial disparity in diabetes incidence in middle age.
An interactive, personalized simulation can change behavioral intentions among individuals with type 2 diabetes.
Patients identified with increased insulin resistance following intra-articular corticosteroid injection or any systemic steroid treatment might need a special emphasis regarding management and followup.
Efforts to reduce takeaway meal consumption in children could have both short-term and long-term health benefits.
In this phase 3 study, statistically and clinically meaningful improvements in HbA1c, body weight, and the proportion of patients achieving goal HbA1c <7% (53mmol/mol) were demonstrated with 2 doses of ITCA 650 vs placebo.
Findings showed that as the estimated glomerular filtration rate decreased and the blood urea nitrogen level increased, the risk for incident diabetes became progressively more pronounced.
A community-based program improves quality of life and self-management in older adults with type 2 diabetes and comorbidities.
A new formulation of exenatide extended-release that is supplied in a once-weekly, single-dose autoinjector device that comes prefilled with a pre-attached hidden needle, is now available.
An individualized approach to glycemic control in type 2 diabetes is likely to reduce costs and improve quality of life.
Findings accentuate the much greater concern regarding clinical outcomes in participants who did not respond to metformin monotherapy.
For patients with type 2 diabetes, all weight categories show increased long-term mortality, with a nadir at a body mass index of 25 to <30.
Well-constructed and individualized nutrition therapy programs were found to effectively reduce HbA1c and BMI in individuals with type 2 diabetes.
The DiRECT study provides the first evidence from a randomized trial of a dietary and lifestyle intervention with remission of type 2 diabetes as a primary outcome.
For patients with type 2 diabetes undergoing non-cardiac surgery, premedication with liraglutide is associated with reduced median plasma glucose 1 hour postoperatively.
A smart exendin-4 delivery device is a promising therapeutic option for type 2 diabetes that can provide safe, long-term, and on-demand Ex4 therapy.
The FDA has granted marketing clearance of the first shock wave device intended for use in the treatment of chronic, full-thickness diabetic foot ulcers.
Researchers assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from 14,094 patients.
Risk of cardiovascular events in people with type 2 diabetes and subgroups of coronary artery disease was examined.
Steglatro is indicated as adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, and Steglujan is indicated as adjunct when treatment with both ertugliflozin and sitagliptin are appropriate.
While there is increasing positive data for the utilization of ranolazine, a majority of the data did not come from large randomized controlled trials that looked at metabolic parameters as their primary end point.
Corticosteroids should be used with caution in patients with diabetes and mitigating factors should be considered.
Network meta-analysis provided some information on differences between DPP-4 inhibitors, traditional anti-diabetes agents, and placebo in bone fracture.
Patients from 3 sites participated in a trial examining the noninferiority of telemedicine vs standard outpatient care for diabetic foot ulcer follow-up treatment.
Urinary albumin-to-creatinine ratio can be independently associated with various adverse CV outcomes.
Study sought to determine the optimal dosing of linagliptin for the treatment of children with type 2 diabetes.
Patients with diabetes report worse quality of life with more intensified treatment, demonstrating the importance of measuring quality of life outcomes when evaluating diabetes treatments.
Investigators sought to examine whether individuals with prediabetes, based on A1c and fasting plasma glucose levels, would have a diagnosis of diabetes when using a 2-hour plasma glucose test.
Endocrinology Advisor Articles
- Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes
- HbA1c Levels Predictive of Liraglutide Treatment Response in T2D
- Comorbid and Pharmacologic Factors Increase Risk for Gastrointestinal Disorders in Diabetes
- ADA Updates Guidelines for Cardiovascular Risk Management in Diabetes
- Clinicians May Be Overtreating Older Patients With Diabetes
- USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention
- Obesity Risk in Infants Born to Women With Diabetes
- Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis
- Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers
- Oxyntomodulin Augments Glucose Homeostasis