Type 2 Diabetes Archive
Risk for type 2 diabetes, ischemic heart disease, and peripheral vascular disease was elevated among patients with psoriatic arthritis compared with the general population.
For patients with type 2 diabetes and acute coronary syndrome, lixisenatide can slow or prevent damage to the kidneys.
Insulin products chart with pharmacokinetic properties.
In this new analysis, researchers looked at the long-term effects of the drug on diabetes prevention and remission in these patients.
Recommendations in the report highlight the importance of patient-centered decision making for glycemic management and improving diet and exercise for patients with T2D.
Standard pen needles have an outer cover and removable inner needle cover, while safety pen needles have an outer cover and a fixed inner needle shield that is not removed before an injection.
Obesity is associated with loss of disease-free years irrespective of position in the social hierarchy and lifestyle.
Combination therapies of basal insulin with either vildagliptin or lixisenatide are similarly effective at producing glycemic control improvements.
Clusters of type 2 diabetes loci and traits have been identified.
Findings from the study showed a graded association between shorter average sleep duration and higher HbA1c concentrations among participants with diabetes.
Substituting processed red meat with poultry or fish and replacing total red meat with fish were associated with a lowered risk for type 2 diabetes.
Compared with the general population, patients with type 2 diabetes are at a 35% to 60% greater risk for atrial fibrillation.
Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.
Investigators assessed the time in range according to a continuous glucose monitor and the risk for diabetic retinopathy.
Investigators examined the effects of insulin glargine 300 U/mL vs insulin glargine 100 U/mL on glycated hemoglobin, hypoglycemia, and body weight change.
Investigators examined patient factors that affect the use of diabetes medication in patients with type 2 diabetes.
Researchers aimed to determine whether variations in phosphocreatine recovery rates were marked by distinct epigenomic muscle profiles that could be seen prior to training.
The high prevalence of obstructive sleep apnea syndrome in both type 1 and type 2 diabetes may favor screening in these patients.
Endocrinology Advisor interviewed experts to explore mechanisms, clinical implications, and research needs pertaining to the diabetes-dementia link.
The prevalence of type 1 and type 2 diabetes is 0.5 and 8.5 percent, respectively, among U.S. adults.
SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.
HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.
Investigators examined the effects of a 12-month collaborative care program for patients with late-life depression on the 9-year incidence of diabetes in older individuals.
Researchers suggest complement pathway activation plays a role in diabetic kidney disease progression in people with proteinuria.
Investigators examined the rates and risk factors for type 2 diabetes in individuals with chronic kidney disease.
The affordability and availability of diabetes medications across multiple regions of the word were examined, along with the effects on the use of medications.
Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.
Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.
Individuals with type 2 diabetes intensifying within 12 months of the index date had a significantly shorter median time from intensification to glycemic control.
Researchers concluded noninferiority between two basal insulin analogs after comparing safety and efficacy end points.
The authors searched for randomized placebo-controlled trials (December 1, 2008 to November 24, 2017) involving 3 pharmacologic classes of antidiabetic medications to compare the effects of these agents on the risk of hospitalization for HF in T2DM patients.
Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.
Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.
Researchers conducted a retrospective analysis to determine whether second-line treatment options sulfonylureas, DPP-4 inhibitors, and thiazolidinediones were associated with reduced HbA1c levels.
Investigators aimed to assess the effect of psychotropic medications, BMI, duration of schizophrenia, number of hospitalizations, and physical activity on the risk for T2D.
To determine the legacy effect of early glycemic control, researchers followed a cohort of 34,737 patients with newly diagnosed diabetes for an average of 13 years.
Diabetes and smoking are vascular risk factors associated with hippocampal calcification in older patients with memory issues.
WHO has developed guidelines for selecting therapy for treatment intensiﬁcation in type 2 diabetes and on the use of insulin in type 1 and 2 diabetes in resource-poor settings.
Investigators examined carotid plaque composition and remodeling using magnetic resonance imaging in patients who were diagnosed with type 2 diabetes for a short duration.
Significant improvement for older adults with depression, COPD; diabetes, cardiovascular disease.
Researchers from the University of Southern California in Los Angeles examined the impacts of Medicaid expansion on access to diabetes medications.
The infection developed within several months of the patients starting SGLT2 therapy and the drug was discontinued in most cases. All patients required surgery and there was 1 reported death.
Investigators examined the excess risk for heart failure in patients with type 2 diabetes and compared the risk with that in the general population without diabetes.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.
Antipsychotic-treated patients with severe mental illnesses have a high prevalence of diabetes and prediabetes.
Investigators sought to determine whether excess risk factors for death and cardiovascular events in patients with type 2 diabetes could be reduced or eliminated.
In the absence of obesity, patients with PTSD are not at an increased risk for type 2 diabetes.
Clinical Characteristics Altering Risks and Benefits of Sulfonylureas and Thiazolidinedione Therapy in T2D
Investigators examined patterns of benefits and risks associated between the sex and BMI of different patient subgroups and sulfonylurea and thiazolidinedione therapies.
But temporary increase in type 2 diabetes risk does not attenuate benefits on total, CVD mortality.
Clinical awareness of the bi-directional association may improve prevention and treatment of both diseases.
Investigators examined the effect of bariatric surgery and the incidence of microvascular complications in type 2 diabetes.
Investigators sought to determine whether the use of dipeptidyl peptidase-4 inhibitors is associated with the incidence of rheumatoid arthritis.
Greater adherence to an overall healthy lifestyle is associated with a substantially lower risk for cardiovascular disease.
Antidiabetic agents for the treatment of diabetes including maintenance and max doses.
Sitagliptin May Improve Glycemic Control Better Than Dapagliflozin in T2D With Mild Renal Insufficiency
The safety and efficacy of sitagliptin vs dapagliflozin in patients with type 2 diabetes and renal insufficiency was examined.
Intermittent energy restriction diet may be an effective alternative diet strategy for reducing HbA1c in patients with type 2 diabetes.
Investigators assessed the effect of second-line therapies on weight, HbA1c, and treatment persistence over 18 months in patients who had received metformin monotherapy.
Combination treatment with dapagliflozin plus omega-3 carboxylic acids may reduce fat content in nonalcoholic fatty liver disease.
More than 25 percent of older U.S. adults with diabetes use some type of complementary and alternative medicine.
A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators examined cardiometabolic risk factor trajectories in patients diagnosed with type 2 diabetes over the course of 13 years preceding diabetic polyneuropathy.
Circulating hepatic markers may predict the risk for diabetes in women.
Investigators evaluate the performance of the G6 factory-calibrated continuous glucose monitoring system over 10 days.
For patients with asymptomatic left ventricular systolic dysfunction (ALVSD), those with diabetes have increased risk of heart failure development and hospitalization.
Partners of people with newly diagnosed diabetes have small but significant differences in health-related behavioral changes compared with partners of people without diabetes.
Comorbid depression, when not well controlled, can affect one's ability to self-manage diabetes. There can be loss of interest in making proper lifestyle choices, monitoring glucose levels, and taking one's medicines.
Investigators aim to identify risk factors for hippocampal calcifications and to investigate the relationship between hippocampal calcifications and cognitive function.
Investigators examined whether incretin-based therapies increase the risk for diabetic retinopathy compared with other antihyperglycemic agents.
Researchers assessed whether adding or switching to sulfonylureas is linked to increased risk for myocardial infarction, ischemic stroke, hypoglycemia, and all-cause mortality.
Results support that there is a relationship between diabetic retinopathy and Parkinson disease.
For patients with type 2 diabetes, characteristics of those with severe hypoglycemia include having a prior diagnosis of non-severe hypoglycemia and hemoglobin A1c (HbA1c) <6 percent.
Particulate matter (PM) with a diameter of less than 2.5 micrograms per cubic meter of air (PM2.5) makes a substantial contribution to the burden of diabetes.
A meta-analysis was conducted to examine the safety and efficacy of basal insulin analogs for type 2 diabetes.
In the AWARD-7 trial, patients who received Trulicity 0.75mg or 1.5mg in combination with mealtime insulin lispro achieved similar glycemic control with weight loss vs patients who received traditional basal-bolus insulin.
Results showed the overall safety profile of linagliptin in study patients, including adults with kidney disease, was consistent with previous data.
Adjustment of glucose-lowering medications in patients who are at high-risk for severe hypoglycemia may be beneficial to prevent mild cognitive impairment.
A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.
The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function.
A retrospective, observational study was conducted to assess outcomes in patients with type 2 diabetes treated with second-generation basal insulin analogs.
For patients with type 2 diabetes mellitus (T2DM), travel costs relating to hemoglobin A1c (HbA1c) screening constitute a substantial cost item, and self-monitoring can reduce costs.
Finnish investigators evaluated the link between diabetes medications other than DPP-4 inhibitors and the risk for BP.
Investigators examined whether β-cell function can be improved or preserved with antihyperglycemic agents in young patients.
Increased spending per encounter has been the biggest driver of overall rise in spending.
Investigators examined the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes.
Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.
Glycemic control with once-weekly dulaglutide was similar to that with insulin glargine in patients with type 2 diabetes and moderate to severe chronic kidney disease.
Investigators examined the association between risk for T2D and comorbid depressive and anxiety symptoms.
Investigators examined gender differences in baseline characteristics and outcomes in patients with t2d and ASCVD.
Glargine 300 is associated with significantly lower annualized rates of documented symptomatic hypoglycemia than Gla-100.
Investigators assessed whether intensification of type 2 diabetes therapy affects health status and quality of life.
The role of low-dose levothyroxine to increase β-oxidation of fatty acids and decreases intrahepatic lipids in patients with type 2 diabetes was examined.
IDegLira is a cost-effective alternative to basal bolus insulin therapy with insulin glargine U100 plus insulin aspart.
Study shows increased risks of autism spectrum disorder in association with types 1, 2, gestational diabetes.
CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy
Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.
Metformin use in patients with chronic kidney disease and the risk for lactic acidosis was examined.
Investigators compared 2 methods of delivering bolus insulin, pen vs patch, using metrics from continuous glucose monitoring.
Investigators conducted a meta-analysis to compare the efficacy of SGLT2i, DPP-4i, and GLP-1 agonists for reducing cardiovascular outcomes.
Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.
Endocrinology Advisor Articles
- Fasting Glycemic Variability Indicates Increased Risk for Type 2 Diabetes
- Vegan Diet Associated With Weight Loss and Reduced Insulin Resistance
- Exercise After Overnight Fasting Stabilizes Glucose Levels in Type 1 Diabetes
- Heritability of BMI Stronger in Obesogenic Environments
- Obesity in Adolescent Girls Associated With Negative Outcomes in Adulthood
- Updated ADA, EASD Consensus Guidelines for Managing Hyperglycemia in T2D
- Vegan Diet Associated With Weight Loss and Reduced Insulin Resistance
- Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression
- Muscle Cell Proﬁles Relate to Exercise Response Variation in Type 2 Diabetes
- Levonorgestrel-Releasing Intrauterine System Approved for 5-Year Use
- Addressing Ethical Challenges Associated With Precision Medicine
- Unapproved Active Pharmaceuticals Identified in Many Dietary Supplements
- Periodic Fasting May Reduce Medication Use in T2D
- Heritability of BMI Stronger in Obesogenic Environments