Gastric Emptying in Type 1 Diabetes Unaffected by Liraglutide

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Liraglutide does not affect rate of gastric emptying during hypoglycemia in type 1 diabetes.
Liraglutide does not affect rate of gastric emptying during hypoglycemia in type 1 diabetes.

HealthDay News -- For individuals with type 1 diabetes, liraglutide therapy does not affect the rate of gastric emptying during hypoglycemia, according to a study published in Diabetes, Obesity and Metabolism.

Christian Seerup Frandsen, MD, from the University of Copenhagen in Denmark, and colleagues examined the effect of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on counterregulatory responses and gastric emptying rate during hypoglycemia in individuals with type 1 diabetes in a 12-week randomized trial. 

Twenty patients aged older than 18 years and with glycated hemoglobin ≥8% were randomly assigned to liraglutide once daily or placebo as add-on to insulin treatment. A hypoglycemic clamp was carried out followed by a liquid meal before and at the end of treatment.

The researchers observed no significant between-group differences in the changes in gastric emptying rates after 12 weeks of treatment (P =.96); no significant changes were seen from baseline whether assessed by area under the acetaminophen curve or time to peak. Similar between-group results were seen in secondary end points, including glycemic recovery, counterregulatory hormone responses, systolic blood pressure, and GLP-1 and pancreatic polypeptide responses. There was an increase in heart rate with liraglutide (69 ± 4 to 80 ± 5 beats/min; P =.02).

"Liraglutide does not compromise glycemic recovery, [gastric emptying] rate, or counterregulatory hormone responses in type 1 diabetes during hypoglycemia," the researchers wrote.

Disclosures: Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which funded the study.

Reference

  1. Frandsen CS, Dejgaard TF, Andersen HU, et al. Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: a randomised, placebo-controlled, double-blind, parallel-group study. Diabetes Obes Metab. 2016 Nov 21. doi:10.1111/dom.12830 [Epub ahead of print].
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