In Type 1 Diabetes, Cumulative Incidence of ESRD is Low

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Patients with type 1 diabetes have a low cumulative incidence of end-stage renal disease and increased mortality.
Patients with type 1 diabetes have a low cumulative incidence of end-stage renal disease and increased mortality.

HealthDay News -- Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published in Diabetes Care.

Vibeke Gagnum, from Oslo University Hospital in Norway, and colleagues examined the long-term mortality, causes of death, and ESRD in a population-based cohort study involving 719 patients with type 1 diabetes diagnosed at ages 15 to 27 years. Information on causes of death and whether ESRD was present was obtained from linkage to national registries.

The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up. Cumulative mortality was 6.0% at 10 years since diagnosis, 12.2% at 20 years, and 18.4% at 30 years. The standardized mortality ratio was 4.4. There was a mean of 23.6 years from diabetes diagnosis to ESRD. Causes of death included chronic complications (32.2%), acute complications (20.5%), violent death (19.9%), or any other cause (27.4%). In 15% of cases, death was related to alcohol.

"The cumulative incidence of ESRD was low in this cohort with type 1 diabetes followed for 30 years," the researchers wrote. "Mortality was 4.4 times that of the general population, and more than 50% of all deaths were caused by acute or chronic complications."

Reference

  1. Ranjan A, Schmidt S, Damm-Frydenberg C, et al. Low carbohydrate diet impairs the effect of glucagon in the treatment of insulin-induced mild hypoglycemia: a randomized cross-over study. Diabetes Care. 2016 Oct 21. doi:10.2337/dc16-1472.
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