Digital Assistant to Artificial Pancreas Improved Glucose Control in Type 1 Diabetes

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Use of the device on a smartphone reduced hypoglycemia and increased time in range.
Use of the device on a smartphone reduced hypoglycemia and increased time in range.

(HealthDay News) — For patients with type 1 diabetes, a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs]) improves glucose control at home in closed-loop control (CLC) modes, according to a study published in Diabetes Care.

Stacey M. Anderson, MD, from the University of Virginia in Charlottesville, and colleagues examined the efficacy of the DiAs on glucose control in 30 participants with type 1 diabetes aged 18 to 66 years at 6 clinical centers in 4 countries. The protocol included a 2-week baseline sensor-augmented pump period followed by a 2-week overnight-only CLC and a 2-week 24/7 CLC at home.

The researchers found that, compared with baseline, glycemic control parameters for overnight-only CLC were improved during the nighttime period for hypoglycemia (time <70 mg/dL, 1.1% vs 3.0%), time in target (70 mg/dL to 180 mg/dL, 75% vs 61%), and glucose variability (coefficient of variation, 30% vs 365; all P<.001). Compared to baseline, there were similar improvements for day/night combined with 24/7 CLC (1.7% vs 4.1%; 73% vs 65%; and 34% vs 38%, respectively; all P<.001).

"CLC running on a smartphone (DiAs) in the home environment was safe and effective," the researchers wrote."Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day."

Several authors disclosed financial ties to the biopharmaceutical industry; equipment for the study was provided by Dexcom, Roche, and Abbott.

Reference

  1. Anderson SM, Raghinaru D, Pinsker JE, et al; for the Control to Range Study Group. Multinational Home Use of Closed-Loop Control Is Safe and Effective. Diabetes Care. 2016. doi:10.2337/dc15-2468.
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