Type 1 Diabetes Archive
Study assessed the effects of sotagliflozin vs placebo with respect to glycemic control and the occurrence of severe hypoglycemia and diabetic ketoacidosis among adults with type 1 diabetes.
Dapagliflozin improves glycemic control in patients with inadequately controlled type 1 diabetes currently taking insulin.
A new study suggests that pancreatic exocrine dysfunction develops after initiation of islet cell autoimmunity, suggesting that exocrine dysfunction is related to diabetes disease pathogenesis itself.
Study aimed to determine the effect of metformin on vascular health in children with T1D and above average weight.
Lower incidence of microalbuminuria was noted with the use of ACE inhibitors vs placebo.
Study finds for the first time that during pregnancy the associations between serum 25OHD concentration and 2 single nucleotide polymorphisms are stronger in mothers of children with T1D.
Adapting open-loop settings that are used by the artificial pancreas algorithm is easily understandable and transparent to both patients and physicians.
With this statement, researchers hope to improve safety and efficacy outcomes, advance technology, and improve patient quality of life and health outcomes.
Overall reduction in HbA1c was higher in people with T2D vs those with T1D.
Daily financial incentives improved glucose monitoring, but not glycemic control.
With a little communication, children with diabetes can still enjoy Halloween festivities.
Twenty-five percent of people with type 2 diabetes and 12% of people with type 1 diabetes had depression.
Although the incidence of severe hypoglycemia has decreased while insulin pump use has increased, a causal relationship has not been established between insulin administration methods and risk of complications from diabetes.
Although continuous glucose monitoring accuracy and safety in preterm infants has been validated in several studies, this approach has never been studied in neonates.
For medicare recipients it is more common to be overtreated than undertreated for diabetes.
Results indicate that blood glucose monitoring should be conducted in hospitalized patients with diabetes.
New monitoring system involves the placement of a small sensor wire beneath the skin surface to continuously monitor glucose levels.
PCI has been linked to increased risk of CHD, mortality, MI, and repeat revascularization in type 1 diabetes.
The 2009 H1N1 swine flu pandemic has been linked to an increased risk of new-onset type 1 diabetes in children.
Glycemic Control in Physically Active Adolescents With T1D: Closed-Loop Control vs Remote Pump in Winter Sports
During a 5-day ski camp, researchers examined closed-loop insulin management vs a remote monitored pump system for glycemic control with the additional challenge of cold and altitude.
More awareness for afib risk factors including age, severity of complications, and glycemic status are needed.
The ADA 2017 Standards of Medical Care in Diabetes focuses on monitoring and pharmacologic approaches for type 1 diabetes management.
High-risk genotypes represent 6.4% of the included study population, but accounted for 61% of all cases of T1D.
Prevalence of celiac disease in type 1 diabetes was higher in girls than in boys.
Compared with insulin glargine, insulin degludec significantly reduced rates of hypoglycemia in patients with either type 1 or type 2 diabetes.
Parents of children with an increased genetic risk for type 1 diabetes had higher level of anxiety.
Patients with assumed monogenic diabetes were examined using a novel 3-part biomarker screening pathway to detect incorrectly diagnosed cases of type 1 diabetes.
Left ventricular function can be improved, but not normalized, in adolescents with type 1 diabetes.
Tentative FDA approval has been granted to Merck's follow-on biologic basal insulin injection.
Long-term differences in HbA1c readings were larger than expected in black vs white patients.
The prevalence of diabetes and impairment in glucose metabolism are noticeably higher in psychiatric patients.
Hand pain, disability, and stiffness were common in long-term type 1 diabetes.
Data from a phase 1 study was presented at the 2017 ADA Scientific Sessions.
Over 3% of study participants with type 1 diabetes also had biopsy-confirmed celiac disease.
New recommendations suggest that frequency of diabetic retinopathy screening should be guided by patients' HbA1c levels.
Although metformin did not improve glycemic control in patients with type 1 diabetes, the treatment did improve cardiovascular disease risk management.
Diabetic ketoacidosis led to fatal demise, preterm birth, and neonatal intensive care unit admissions.
Hypoglycemic episodes, moderate or severe, can effectively and efficiently be managed by nasal glucagon in adult patients with type 1 diabetes.
Mental health and behavioral screenings should be routine part of care for pediatric patients with diabetes
A new point-of-care C peptide test may increase ease and access to testing for patients with type 1 and type 2 diabetes.
In all groups of participants, a lower HbA1c was associated with a better health-related quality of life in type 1 diabetes.
A single session of HIIT can "rapidly reduce" awareness of hypoglycemia in patients with type 1 diabetes.
First look at research to be presented at ADA 2017.
Both mealtime and postmeal faster insulin aspart are noninferior to mealtime conventional insulin aspart, regarding HbA1c change from baseline.
There is a 5% probability of progression from state 1 to state 5 between retinal screenings.
Researchers examined whether within-day glycemic variability plays a role in microvascular complications.
Febuxostat was found to have a modest impact in lowering systolic blood pressure among patients with type 1 diabetes.
Patients with type 1 diabetes had higher mortality rates when admitted for acute myocardial infarction compared with patients with type 2 diabetes.
A randomized controlled trial assessed whether mild lower extremity compression can be safely used in patients with diabetes and concurrent lower extremity edema.
PLGM tied to smaller number of hypoglycemic events; increase in time spent 140 mg/dL
A study sought to determine if a virtual glucose management service can result in improved inpatient glycemic control.
Adjuvant metformin produced a small but nonsignificant decrease in body mass index and insulin dose, but by year 10, no beneficial effects were evident.
Black and Latino youth were less likely to undergo an eye examination for diabetic retinopathy within 6 years of their diagnosis.
The prevalence of complications associated with type 1 and type 2 diabetes diagnosed during childhood and adolescence was compared in a multicenter, observational study.
Age-adjusted diabetes incidence increased for every 1 degree celcius temperature increase.
A study found approximately one-third of people with diabetes were undiagnosed or unaware of the diagnosis.
An update to the ADA's 2017 Standards of Medical Care in Diabetes indicates that, barring contraindication, patients with type 2 diabetes should undergo metformin therapy as first-line treatment.
Insulin types and regimens should be determined on an individual basis since there is insufficient data to support one treatment over another.
Investigators found early signs of kidney disease, retinopathy, arterial stiffness, and hypertension in adolescents with either type 1 or type 2 diabetes.
Children younger than 12 were at an elevated risk of type 1 diabetes.
The studies will assess the safety, efficacy, and user-friendliness among other aspects, of multiple artificial pancreas devices.
Exercise management for patients with type 1 diabetes should be individualized, depending on insulin concentrations and exercise type/intensity.
Patients with type 1 diabetes who used multiple insulin injections daily experienced reductions in HbA1c with continuous glucose monitoring.
The use of hydrolyzed vs nonhydrolyzed cow's milk-based infant formula does not appear to reduce risk for islet autoimmunity.
People with type 1 diabetes have specific changes in gut bacteria and inflammation of the digestive tract compared with people without the disease.
A recent study confirms that frequent enterovirus infection may contribute to the development of type 1 diabetes in children.
The FDA's expanded indication for the Dexcom G5 Continuous Glucose Monitoring System allows for replacement of fingerstick glucose testing.
The risks of ischemic and hemorrhagic stroke are increased with type 1 diabetes, with incrementally increasing risks with increasing HbA1c.
The patient became severely hypoglycemic within 10 to 12 hours after taking the pain drug.
A standardized sliding scale insulin (SSI) order sheet can reduce the incidence of SSI-related medication errors.
For patients with type 1 diabetes, the incidence of hospitalization for hypoglycemia decreased over time in Denmark, with an 8.4% annual decrease.
For patients with type 1 diabetes, blood pressure (BP) of <120/70 mm Hg is associated with a substantially reduced risk of adverse renal outcomes.
For individuals with type 1 diabetes, liraglutide therapy does not affect the rate of gastric emptying during hypoglycemia.
Arsenic metabolism seems to be associated with type 1 diabetes in young people, with a potential interaction by folate levels.
Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up.
For patients with type 1 diabetes, the correlation between PCSK9 and LDL cholesterol is only seen in the highest tertile for HbA1c.
Low-carbohydrate diet results in lower incremental rises in plasma glucose after mild hypoglycemia.
Neonatal phototherapy is not associated with type 1 diabetes, according to a study published in Pediatrics.
Treated diabetic retinopathy is extremely rare among children with type 1 diabetes, according to research published in Diabetes Care.
Young adults with long-standing, childhood-onset type 1 diabetes have increased total and cardiovascular disease mortality.
Approval was based on a clinical trial that included 123 people with type 1 diabetes who used the MiniMed 670G hybrid closed-loop system for 3 months, after a 2-week period of no use.
A wide range in the rate of eGFR decline was observed per year.
Researchers assessed whether elevated FABP4 in early pregnancy could predict preeclampsia.
Metformin may help preserve cardiovascular health in patients with type 1 diabetes, according to a study published in Cardiovascular Diabetology.
Patients with type 1 diabetes have more diabetes-associated autoantibodies and non-diabetes-associated autoantibodies than patients with type 2 diabetes.
Smokers with type 1 diabetes have higher glycated hemoglobin and an unfavorable lipid profile.
Experimental study suggests repeated antibiotic exposure is associated with the development of type 1 diabetes.
For pregnant women with type 1 diabetes, closed-loop therapy is associated with a greater percentage of time that overnight glucose levels are in the target range.
Clinicians should consider a number of factors when weighing the risks and benefits of using SGLT2 inhibitors in patients with diabetes.
Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin (HbA1c), body weight, and insulin requirements.
Glucagon should be recognized as a lifesaver for hypoglycemia and a major treatment for diabetes.
Patients with type 1 diabetes assigned to a 3-drug combination — dapagliflozin, liraglutide, and insulin — had superior blood glucose control compared with patients assigned to dapagliflozin monotherapy.
Higher baseline high-sensitivity C-reactive protein (hs-CRP) is associated with less treatment-linked improvement in depression in patients with type 1 diabetes.
C-peptide responses to mixed-meal tolerance tests are reliable surrogates of insulin secretion, according to a study published in Diabetes Care.
Prior severe hypoglycemic events within 1 year was associated with increased risk of all-cause mortality and cardiovascular disease.
An elevated PI:C ratio was linked to progression to type 1 diabetes, especially among children younger than 10 years of age.
Among women with type 1 diabetes there are increased odds of female sexual dysfunction and urinary incontinence associated with specific measures of cardiovascular autonomic neuropathy.
Young patients with very high HbA1c levels with recurrent diabetic ketoacidosis had a higher risk of mortality.
Researchers were able to identify 5 subgroups of diabetes that will help better guide treatment.
Endocrinology Advisor Articles
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- Pregnancy Rates in Women Undergoing IVF With Fresh vs Frozen Embryos
- Effect of Sugar-Sweetened Beverages on Obesity Development
- Increased Risk for Severe Hypoglycemic Events Associated With CV Outcomes
- Exercise May Reduce Abdominal Adiposity, Inflammation Independent of BMI
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- SGLT2 Inhibitors Show High Cardiovascular- and Renal-Protective Effects in T2D
- Two New Diabetes Medications Now Available
- Managing Acute Pain in Patients With Severe Obesity
- Gestational Diabetes May Increase Risk for Hypertension, Ischemic Heart Disease, T2D
- Type 2 Diabetes Insulin Initiation: Predictors Identified
- T2D May Play a Protective Role Against Developing Aortic Diseases
- Reducing Eating Speed May Prevent Obesity in Type 2 Diabetes
- Evaluating the Longitudinal Effects of Diabetes on Cognition
- Denosumab May Increase BMD in Women With Primary Hyperparathyroidism