Type 1 Diabetes Archive
Data from a phase 1 study was presented at the 2017 ADA Scientific Sessions.
Over 3% of study participants with type 1 diabetes also had biopsy-confirmed celiac disease.
New recommendations suggest that frequency of diabetic retinopathy screening should be guided by patients' HbA1c levels.
Although metformin did not improve glycemic control in patients with type 1 diabetes, the treatment did improve cardiovascular disease risk management.
Diabetic ketoacidosis led to fatal demise, preterm birth, and neonatal intensive care unit admissions.
Hypoglycemic episodes, moderate or severe, can effectively and efficiently be managed by nasal glucagon in adult patients with type 1 diabetes.
Mental health and behavioral screenings should be routine part of care for pediatric patients with diabetes
A new point-of-care C peptide test may increase ease and access to testing for patients with type 1 and type 2 diabetes.
In all groups of participants, a lower HbA1c was associated with a better health-related quality of life in type 1 diabetes.
A single session of HIIT can "rapidly reduce" awareness of hypoglycemia in patients with type 1 diabetes.
First look at research to be presented at ADA 2017.
Both mealtime and postmeal faster insulin aspart are noninferior to mealtime conventional insulin aspart, regarding HbA1c change from baseline.
There is a 5% probability of progression from state 1 to state 5 between retinal screenings.
Researchers examined whether within-day glycemic variability plays a role in microvascular complications.
Febuxostat was found to have a modest impact in lowering systolic blood pressure among patients with type 1 diabetes.
Patients with type 1 diabetes had higher mortality rates when admitted for acute myocardial infarction compared with patients with type 2 diabetes.
A randomized controlled trial assessed whether mild lower extremity compression can be safely used in patients with diabetes and concurrent lower extremity edema.
PLGM tied to smaller number of hypoglycemic events; increase in time spent 140 mg/dL
A study sought to determine if a virtual glucose management service can result in improved inpatient glycemic control.
Adjuvant metformin produced a small but nonsignificant decrease in body mass index and insulin dose, but by year 10, no beneficial effects were evident.
Black and Latino youth were less likely to undergo an eye examination for diabetic retinopathy within 6 years of their diagnosis.
The prevalence of complications associated with type 1 and type 2 diabetes diagnosed during childhood and adolescence was compared in a multicenter, observational study.
Age-adjusted diabetes incidence increased for every 1 degree celcius temperature increase.
A study found approximately one-third of people with diabetes were undiagnosed or unaware of the diagnosis.
An update to the ADA's 2017 Standards of Medical Care in Diabetes indicates that, barring contraindication, patients with type 2 diabetes should undergo metformin therapy as first-line treatment.
Insulin types and regimens should be determined on an individual basis since there is insufficient data to support one treatment over another.
Investigators found early signs of kidney disease, retinopathy, arterial stiffness, and hypertension in adolescents with either type 1 or type 2 diabetes.
Children younger than 12 were at an elevated risk of type 1 diabetes.
The studies will assess the safety, efficacy, and user-friendliness among other aspects, of multiple artificial pancreas devices.
Exercise management for patients with type 1 diabetes should be individualized, depending on insulin concentrations and exercise type/intensity.
Patients with type 1 diabetes who used multiple insulin injections daily experienced reductions in HbA1c with continuous glucose monitoring.
The use of hydrolyzed vs nonhydrolyzed cow's milk-based infant formula does not appear to reduce risk for islet autoimmunity.
People with type 1 diabetes have specific changes in gut bacteria and inflammation of the digestive tract compared with people without the disease.
A recent study confirms that frequent enterovirus infection may contribute to the development of type 1 diabetes in children.
The FDA's expanded indication for the Dexcom G5 Continuous Glucose Monitoring System allows for replacement of fingerstick glucose testing.
The risks of ischemic and hemorrhagic stroke are increased with type 1 diabetes, with incrementally increasing risks with increasing HbA1c.
The patient became severely hypoglycemic within 10 to 12 hours after taking the pain drug.
A standardized sliding scale insulin (SSI) order sheet can reduce the incidence of SSI-related medication errors.
For patients with type 1 diabetes, the incidence of hospitalization for hypoglycemia decreased over time in Denmark, with an 8.4% annual decrease.
For patients with type 1 diabetes, blood pressure (BP) of <120/70 mm Hg is associated with a substantially reduced risk of adverse renal outcomes.
For individuals with type 1 diabetes, liraglutide therapy does not affect the rate of gastric emptying during hypoglycemia.
Arsenic metabolism seems to be associated with type 1 diabetes in young people, with a potential interaction by folate levels.
Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up.
For patients with type 1 diabetes, the correlation between PCSK9 and LDL cholesterol is only seen in the highest tertile for HbA1c.
Low-carbohydrate diet results in lower incremental rises in plasma glucose after mild hypoglycemia.
Neonatal phototherapy is not associated with type 1 diabetes, according to a study published in Pediatrics.
Treated diabetic retinopathy is extremely rare among children with type 1 diabetes, according to research published in Diabetes Care.
Young adults with long-standing, childhood-onset type 1 diabetes have increased total and cardiovascular disease mortality.
Approval was based on a clinical trial that included 123 people with type 1 diabetes who used the MiniMed 670G hybrid closed-loop system for 3 months, after a 2-week period of no use.
A wide range in the rate of eGFR decline was observed per year.
Researchers assessed whether elevated FABP4 in early pregnancy could predict preeclampsia.
Metformin may help preserve cardiovascular health in patients with type 1 diabetes, according to a study published in Cardiovascular Diabetology.
Patients with type 1 diabetes have more diabetes-associated autoantibodies and non-diabetes-associated autoantibodies than patients with type 2 diabetes.
Smokers with type 1 diabetes have higher glycated hemoglobin and an unfavorable lipid profile.
Experimental study suggests repeated antibiotic exposure is associated with the development of type 1 diabetes.
For pregnant women with type 1 diabetes, closed-loop therapy is associated with a greater percentage of time that overnight glucose levels are in the target range.
Clinicians should consider a number of factors when weighing the risks and benefits of using SGLT2 inhibitors in patients with diabetes.
Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin (HbA1c), body weight, and insulin requirements.
Glucagon should be recognized as a lifesaver for hypoglycemia and a major treatment for diabetes.
Patients with type 1 diabetes assigned to a 3-drug combination — dapagliflozin, liraglutide, and insulin — had superior blood glucose control compared with patients assigned to dapagliflozin monotherapy.
Higher baseline high-sensitivity C-reactive protein (hs-CRP) is associated with less treatment-linked improvement in depression in patients with type 1 diabetes.
C-peptide responses to mixed-meal tolerance tests are reliable surrogates of insulin secretion, according to a study published in Diabetes Care.
Prior severe hypoglycemic events within 1 year was associated with increased risk of all-cause mortality and cardiovascular disease.
An elevated PI:C ratio was linked to progression to type 1 diabetes, especially among children younger than 10 years of age.
Among women with type 1 diabetes there are increased odds of female sexual dysfunction and urinary incontinence associated with specific measures of cardiovascular autonomic neuropathy.
Young patients with very high HbA1c levels with recurrent diabetic ketoacidosis had a higher risk of mortality.
Researchers were able to identify 5 subgroups of diabetes that will help better guide treatment.
A program focused on behavior reduced costs and improved glycemic control in children with repeat hospitalizations for diabetic ketoacidosis.
For children with type 1 diabetes, the negative influence of celiac disease on HDL cholesterol can be improved by adherence to a gluten-free diet.
An increase of 1000 steps per day was linked to a decrease in mean/maximum aortic intima-media thickness.
Risk of type 1 diabetes is elevated among children who reverted from single autoantibody to autoantibody negative.
T cell mitochondrial dysfunction in patients with type 1 diabetes may lead to abnormal T cell regulation.
Cumulative life stress was a risk factor for developing islet autoimmunity in children with high type 1 diabetes risk.
Screening for major life events in teens with diabetes who are risk for poor outcomes may improve outcomes.
Mean blood glucose and time experiencing hypoglycemia significantly decreased with bionic pancreas use.
Patients were highly confident in their dogs' ability, but data demonstrated poor predictive value vs CGM.
Patients with type 1 diabetes experienced HbA1c reductions after adding dapagliflozin to liraglutide and insulin.
Early, marked, and sustained loss of islet sympathetic nerves was seen in type 1 but not type 2 diabetes.
Low bedtime glucose and daytime physical activity increase the risk for nocturnal hypoglycemia.
Artificial pancreas was linked to 3-fold reduction of time-in-hypoglycemia for 5- to 9-year-olds.
The increasing global prevalence of type 1 diabetes appears to be directly linked to advances in medical care.
All-cause, cardiovascular disease, and diabetes age-standardized mortality rates have decreased from 2000 to 2011.
Infants who experience a respiratory or viral infection during the first 6 months of life have an increased risk of developing type 1 diabetes.
Treatment is important for primary prevention even without history of cardiovascular disease, researchers said.
Overnight-only and 24/7 closed-loop control reduced hypoglycemia and increased time in range.
Researchers found variation in the percent of the total 4-hour C-peptide area under the curve captured in the first 2 hours.
The vaccine also restored normal glucose tolerance.
The addition of 1.2 and 1.8 mg liraglutide was associated with modest reductions of weekly mean glucose levels.
The development of islet autoimmunity was associated with weight z-scores at 12 months of age.
Overnight insulin requirements are significantly more variable than daytime or total daily insulin needs.
Unlike in adults, there is no association between uric acid and cardiorenal parameters.
Type 1 diabetes was associated with differences in risk for various common cancers, but the relationship was affected by diabetes duration.
Mini-dose glucagon may be an effective treatment option for mild to moderate hypoglycemia in adults with type 1 diabetes.
Patients with type 1 diabetes in the Diabetes Control and Complications Trial experienced beneficial cardiovascular outcomes after 30 years follow-up.
While there was no overall improvement, treatment with long-acting C-peptide improved vibration perception threshold.
For patients with type 1 diabetes, fat quality influences postprandial blood glucose response in the context of meals with high glycemic index.
Studies assess ways to overcome challenge of foreign body response with alginate derivative
The FDA has approved Humulin R U-500 KwikPen, which is 5 times more concentrated than standard insulin injections.
For patients with diabetes and chronic diabetic foot ulcers, hyperbaric oxygen therapy does not reduce indications for amputation.
Endocrinology Advisor Articles
- Imaging Studies in Hypothyroidism Evaluation Linked to Unnecessary Risks
- Lower Risk for SGLT2i-Associated Genitourinary Infection With DPP-4i
- Insulin Glargine Associated With Breast Cancer Risk in T2D
- Transoral Endoscopic Thyroidectomy Vestibular Approach: Safety and Outcomes
- Once-Weekly Omarigliptin Improves Glycemic Control in Type 2 Diabetes
- Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk
- Lower Risk for SGLT2i-Associated Genitourinary Infection With DPP-4i
- Severe Hypoglycemia Associated With Increased Mortality Risk in T2D
- Efficacy of CGM in Preterm Infants of Mothers With Diabetes
- Expert Roundtable: AHA Update on Dietary Fat Intake and CVD Risk
- Increased Risk of Diabetes, Post-Diabetes Pneumonia for Patients With COPD
- Pancreatic Exocrine Dysfunction Occurs After Islet Autoimmunity in T1D
- T2D in African American Women Ups ER-negative Breast Cancer Risk
- High-Sensitivity CRP and LDL-C Predictive of Subsequent MACE in T2D
- Risks Associated With Denosumab Discontinuation