Type 1 Diabetes Archive
Investigators aim to identify risk factors for hippocampal calcifications and to investigate the relationship between hippocampal calcifications and cognitive function.
Ambulatory blood pressure monitoring in addition to office readings may effectively be able to identify individuals who are at high risk for CVD in T1D.
Investigators examined the effects of antithymocyte globulin with or without pegylated granulocyte colony-stimulating factor on β-cell function and HbA1C.
Investigators examined whether incretin-based therapies increase the risk for diabetic retinopathy compared with other antihyperglycemic agents.
Particulate matter (PM) with a diameter of less than 2.5 micrograms per cubic meter of air (PM2.5) makes a substantial contribution to the burden of diabetes.
The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function.
For this study, researchers conducted a randomized, double-blind, placebo-controlled Phase 2 trial (N=24) to assess the efficacy and safety of adding oral verapamil for 12 months to a standard insulin regimen in adults with recent-onset type 1 diabetes (age range: 18 to 45 years).
Increased spending per encounter has been the biggest driver of overall rise in spending.
Significant, sustained decrease in blood glucose levels with low insulin doses of 3 to 10 U/kg.
Investigators examined the effect of the Penn Resilience Program for type 1 diabetes on diabetes-related distress, depressive symptoms, resilience, diabetes self-management, and glycemic control in a cohort of adolescents.
Identifying phases of C-peptide decline may be valuable for understanding β-cell survival.
Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.
Stigma is associated with two-fold higher odds of poor glycemic control after adjustment for confounders.
Mini-dose glucagon was as effective as glucose tablets for preventing hypoglycemia and may result in less post intervention hyperglycemia.
ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.
Study shows increased risks of autism spectrum disorder in association with types 1, 2, gestational diabetes.
CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy
Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.
Investigators conducted a randomized crossover comparison of 2 dual-hormone artificial pancreas systems — one with rapid insulin and amylin, and another with regular insulin and amylin — with a rapid insulin-alone artificial pancreas.
Researchers conducted a randomized, open-label trial to assess the effect of an automated closed-loop insulin delivery system on glycemic control in hospitalized patients.
Patients were randomly assigned to receive insulin aspart or Technosphere inhaled insulin.
The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.
In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.
After insulin optimization, participants with type 1 diabetes were randomly assigned to placebo, sotagliflozin 200 mg, or sotagliflozin 400 mg with insulin.
Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.
Reducing basal insulin delivery by 50%-80% 90 minutes before aerobic exercise better prevents hypoglycemia risk vs basal suspension or disconnection at exercise onset.
The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.
The FDA has granted Orphan Drug Designation to PCS499 (Processa Pharmaceuticals) for the treatment of necrobiosis lipoidica.
U.S. officials need to take action to control spiking insulin prices, the American Medical Association says.
Children of parents experiencing stressful and severe life events in early childhood may be at risk for type 1 diabetes developing.
Researchers examined patterns of diabetes self-management behaviors and predictors of glycemic control in 7,153 adults enrolled in the Type 1 Diabetes Exchange clinic registry.
Investigators recorded hypoglycemic symptoms and monitored blood sugar levels by continuous glucose monitoring for 6 days.
Investigators seek to determine he effects of continuous glucose monitoring on daytime and nocturnal hypoglycemia in patients with type 1 diabetes.
The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.
Investigators examined glycemic control variations in 8 high-income countries from multicenter registries in children with type 1 diabetes.
For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia.
For children and adults with type 1 diabetes, consuming a very low-carbohydrate diet is associated with exceptional glycemic control.
Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.
Brief structured education in addition to informed support in active insulin dose self-adjustment underpinned by targeted self-monitoring of blood glucose lead to sustained falls in severe hypoglycemia rates in individuals at high risk.
Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D
The study highlights mitochondrial and autophagic differences in the muscles of young adults with type 1 diabetes with moderate glycemic control who exceed recommended activity levels.
The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.
Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.
For patients with type 1 diabetes, artificial pancreas treatment is efficacious, increasing the proportion of time spent in the near normoglycemic range.
Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle.
Awareness of ASD and its manifestations and comorbidities remain imperative in the treatment of T1D, as both conditions require long-term medical follow-up to continue improving diabetes care and metabolic control outcomes.
The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.
For adults with type 1 diabetes with suboptimal control despite using multiple insulin injections, continuous glucose monitoring seems cost-effective, with improved glucose control.
Telemedicine could provide real-time feedback loop and allow pharmacists to help patients self-manage.
Young adults with type 1 diabetes have altered neural responses during working memory processing.
IPITA and EPITA held a workshop to develop consensus for a joint statement on the definition of function and failure of current and future forms of β-cell replacement therapy.
Researchers conducted a systematic literature review to identify studies on cognitive function in children with type 1 diabetes.
Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.
Early treatment of cardiovascular disease risk factors such as dyslipidemia and hypertension will have long-term benefits with low risk and cost and should be more widely used in pediatric type 1 diabetes care.
There are significant improvements in health-related quality of life following islet transplantation in patients with type 1 diabetes complicated by severe hypoglycemia.
Researchers assessed the safety and accuracy of an implantable continuous glucose measurement in adults diagnosed with type 1 and type 2 diabetes.
Study provided evidence of significant differences in median serum concentrations of circulating adipose-related inflammatory biomarkers across the main diabetes types.
The FDA reviewed data for the device through the de novo premarket review pathway, a regulatory pathway for novel, low-to-moderate-risk devices that are not substantially equivalent to an already legally marketed device.
Sanofi announced that the Food and Drug Administration (FDA) has approved Toujeo (insulin glargine 300 Units/mL) Max SoloStar, a long-acting insulin pen that holds 900 Units of Toujeo and provides up to 160 Units/mL per injection.
Researchers assessed whether alcohol intake affects response to glucagon in individuals with type 1 diabetes.
The NDA is based on results from a large placebo-controlled, phase 3 trial that included 1402 patients with type 1 diabetes who were receiving insulin therapy.
Researchers assessed differences in glycemic control, major cardiovascular risk factors, diabetes-related complications, sexual dysfunction prevalence, and endothelial function in young men and women with type 1 diabetes.
For pregnant women with type 1 diabetes, a closed-loop system is associated with comparable glucose control and significantly less hypoglycemia than sensor-augmented pump therapy.
Research findings indicate improved glycemic outcomes in children with T1D using the MiniMed 670G system, similar to those observed for adolescents and adults.
Researchers assessed racial and ethnic differences in outcomes among patients in the first 3 years following diagnosis of type 1 diabetes.
Study found that the absence of proliferative diabetic retinopathy in those with stage 3b chronic kidney disease is associated with a lower prevalence of cardiovascular disease in patients with long duration of type 1 diabetes.
Study suggests that single-hormone artificial pancreas systems may be sufficient for overnight control even in a high-risk group of hypoglycemia-unaware participants with documented nocturnal hypoglycemia.
High-quality studies are needed to determine whether tight intrapartum glycemic control is superior to more relaxed glycemic targets intrapartum for women with diabetes in pregnancy.
Researchers calculated the hazard ratio of ADHD in offspring of patients with type 1 diabetes compared with the general population.
For youth with type 1 diabetes, disordered eating behaviors are associated with higher hemoglobin A1c but not with measures of glycemic variability.
Higher rates of operative delivery and falling gestational age at delivery suggest that this is either reflected by, or despite, increasing obstetric intervention.
Transcription factor 7 like 2 genetic variants contribute to phenotypic heterogeneity of type 1 diabetes.
Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.
Patients with diabetes had higher rates for all 19 infection categories with the highest incidence rate ratios seen for bone and joint infections, sepsis, and cellulitis.
Weaning to a hydrolyzed formula did not reduce the risk of type 1 diabetes in children with an increased disease risk.
Children with T1D had statistically significantly higher prevalence rates of hypertension, hypercholesterolemia, and used more CV medication compared with a matched diabetes-free reference cohort in the period after the onset of diabetes.
Dasiglucagon is well-tolerated and is associated with an early pharmacodynamic response similar to that of GlucaGen for severe hypoglycemia.
Study evaluated the safety and efficacy of autoantigen-specific therapy with alum-formulated glutamate decarboxylase in nondiabetic children with multiple islet autoantibodies.
The cumulative risk of end-stage renal disease among patients with type 1 diabetes has declined over time in Finland.
For patients with type 1 diabetes, there is a bidirectional association between depression and severe hypoglycemia and hyperglycemia.
A previous diagnosis of asthma increases the risk for subsequent type 1 diabetes by 41%, but a previous diagnosis of type 1 diabetes decreases the risk of subsequent asthma by 18%.
In older adults, in whom T1D is rare, patients with diabetes who are positive for autoantibodies are as likely to be false positive with T2D as true positive with T1D.
Corticosteroids should be used with caution in patients with diabetes and mitigating factors should be considered.
A life-course study evaluated the contribution of vascular endothelial dysfunction and inflammation to the development of hypertension in type 1 diabetes.
Although sharing of real-time continuous glucose monitoring data can create tension between patients with type 1 diabetes and family members, it can also facilitate greater empowerment and perceptions of safety among both patients and their caregivers.
Patients with T1D are not susceptible to accelerated lipolysis and ketogenesis, despite the reduction in overnight basal insulin doses during SGLT2i treatment.
Study sought to evaluate whether baseline autonomic dysfunction was predictive of future increases in urine albumin-creatinine ratio in pediatric patients with type 1 diabetes.
Participants reported improvements in many psychosocial variables associated with using an automated bihormonal bionic pancreas system relative to self-management of diabetes using their own insulin pump.
Investigators sought to delay or prevent the onset of type 1 diabetes by administering a once-daily oral insulin tablet.
Representatives from multiple associations and societies have issued a new report standardizing clinically meaningful outcome measures for type 1 diabetes, beyond using HbA1c testing.
Study underscores the need to focus on the peer context to understand the functioning of youths with type 1 diabetes.
Incentive-based approaches developed to improve daily adherence to a single behavioral process, such as blood glucose monitoring in adolescents, may not be as effective as multicomponent interventions that address emotional, social, and family processes of diabetes self-management.
Recommendations for utilizing trend arrow data in a mobile continuous glucose monitoring system were recently issued for pediatric patients with type 1 diabetes.
Patients with prior experience using a continuous glucose monitoring system may benefit from the MiniMed 670G HCL system therapy.
A remotely connected diabetes management system increased patent satisfaction and improved glycemic control in patients with insulin-treated diabetes.
Investigators believe that circulating adipokines may be associated with the development of preeclampsia in women with type 1 diabetes in the first trimester.
Investigators assess maternal hyperglycemia exposure to fetus with neonatal health outcomes.
Islet and celiac disease autoimmunity were defined as a positive test result for islet or tissue transglutaminase autoantibodies at 2 clinic visits at least 3 months apart.
Among patients with childhood-onset type 1 diabetes, there is a very low incidence of end-stage renal disease.
Study assessed the effects of sotagliflozin vs placebo with respect to glycemic control and the occurrence of severe hypoglycemia and diabetic ketoacidosis among adults with type 1 diabetes.
Dapagliflozin improves glycemic control in patients with inadequately controlled type 1 diabetes currently taking insulin.
Endocrinology Advisor Articles
- Behavioral Weight Loss Interventions May Prevent Obesity
- PCSK9 Inhibition: Benefits Outweigh Risks in Patients With Diabetes
- Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D
- Rates of Incident Type 2 Diabetes in Chronic Kidney Disease
- Availability and Affordability of Diabetes Medication Worldwide
- Estradiol, Cortisol, TGF-β1 Involved in Thyroid Immunity During Pregnancy and Postpartum
- Pharmacotherapy Personalization May Optimize Outcomes for Type 2 Diabetes
- Late-Onset Epilepsy Linked to Diabetes
- Examining the Ethical Considerations of Grateful Patient Fundraising
- Muscle Cell Proﬁles Relate to Exercise Response Variation in Type 2 Diabetes