Type 1 Diabetes Archive
Researchers assessed whether alcohol intake affects response to glucagon in individuals with type 1 diabetes.
The NDA is based on results from a large placebo-controlled, phase 3 trial that included 1402 patients with type 1 diabetes who were receiving insulin therapy.
Researchers assessed differences in glycemic control, major cardiovascular risk factors, diabetes-related complications, sexual dysfunction prevalence, and endothelial function in young men and women with type 1 diabetes.
For pregnant women with type 1 diabetes, a closed-loop system is associated with comparable glucose control and significantly less hypoglycemia than sensor-augmented pump therapy.
Research findings indicate improved glycemic outcomes in children with T1D using the MiniMed 670G system, similar to those observed for adolescents and adults.
Researchers assessed racial and ethnic differences in outcomes among patients in the first 3 years following diagnosis of type 1 diabetes.
Study found that the absence of proliferative diabetic retinopathy in those with stage 3b chronic kidney disease is associated with a lower prevalence of cardiovascular disease in patients with long duration of type 1 diabetes.
Study suggests that single-hormone artificial pancreas systems may be sufficient for overnight control even in a high-risk group of hypoglycemia-unaware participants with documented nocturnal hypoglycemia.
High-quality studies are needed to determine whether tight intrapartum glycemic control is superior to more relaxed glycemic targets intrapartum for women with diabetes in pregnancy.
Researchers calculated the hazard ratio of ADHD in offspring of patients with type 1 diabetes compared with the general population.
For youth with type 1 diabetes, disordered eating behaviors are associated with higher hemoglobin A1c but not with measures of glycemic variability.
Higher rates of operative delivery and falling gestational age at delivery suggest that this is either reflected by, or despite, increasing obstetric intervention.
Transcription factor 7 like 2 genetic variants contribute to phenotypic heterogeneity of type 1 diabetes.
Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.
Patients with diabetes had higher rates for all 19 infection categories with the highest incidence rate ratios seen for bone and joint infections, sepsis, and cellulitis.
Weaning to a hydrolyzed formula did not reduce the risk of type 1 diabetes in children with an increased disease risk.
Children with T1D had statistically significantly higher prevalence rates of hypertension, hypercholesterolemia, and used more CV medication compared with a matched diabetes-free reference cohort in the period after the onset of diabetes.
Dasiglucagon is well-tolerated and is associated with an early pharmacodynamic response similar to that of GlucaGen for severe hypoglycemia.
Study evaluated the safety and efficacy of autoantigen-specific therapy with alum-formulated glutamate decarboxylase in nondiabetic children with multiple islet autoantibodies.
The cumulative risk of end-stage renal disease among patients with type 1 diabetes has declined over time in Finland.
For patients with type 1 diabetes, there is a bidirectional association between depression and severe hypoglycemia and hyperglycemia.
A previous diagnosis of asthma increases the risk for subsequent type 1 diabetes by 41%, but a previous diagnosis of type 1 diabetes decreases the risk of subsequent asthma by 18%.
In older adults, in whom T1D is rare, patients with diabetes who are positive for autoantibodies are as likely to be false positive with T2D as true positive with T1D.
Corticosteroids should be used with caution in patients with diabetes and mitigating factors should be considered.
A life-course study evaluated the contribution of vascular endothelial dysfunction and inflammation to the development of hypertension in type 1 diabetes.
Although sharing of real-time continuous glucose monitoring data can create tension between patients with type 1 diabetes and family members, it can also facilitate greater empowerment and perceptions of safety among both patients and their caregivers.
Patients with T1D are not susceptible to accelerated lipolysis and ketogenesis, despite the reduction in overnight basal insulin doses during SGLT2i treatment.
Study sought to evaluate whether baseline autonomic dysfunction was predictive of future increases in urine albumin-creatinine ratio in pediatric patients with type 1 diabetes.
Participants reported improvements in many psychosocial variables associated with using an automated bihormonal bionic pancreas system relative to self-management of diabetes using their own insulin pump.
Investigators sought to delay or prevent the onset of type 1 diabetes by administering a once-daily oral insulin tablet.
Representatives from multiple associations and societies have issued a new report standardizing clinically meaningful outcome measures for type 1 diabetes, beyond using HbA1c testing.
Study underscores the need to focus on the peer context to understand the functioning of youths with type 1 diabetes.
Incentive-based approaches developed to improve daily adherence to a single behavioral process, such as blood glucose monitoring in adolescents, may not be as effective as multicomponent interventions that address emotional, social, and family processes of diabetes self-management.
Recommendations for utilizing trend arrow data in a mobile continuous glucose monitoring system were recently issued for pediatric patients with type 1 diabetes.
Patients with prior experience using a continuous glucose monitoring system may benefit from the MiniMed 670G HCL system therapy.
A remotely connected diabetes management system increased patent satisfaction and improved glycemic control in patients with insulin-treated diabetes.
Investigators believe that circulating adipokines may be associated with the development of preeclampsia in women with type 1 diabetes in the first trimester.
Investigators assess maternal hyperglycemia exposure to fetus with neonatal health outcomes.
Islet and celiac disease autoimmunity were defined as a positive test result for islet or tissue transglutaminase autoantibodies at 2 clinic visits at least 3 months apart.
Among patients with childhood-onset type 1 diabetes, there is a very low incidence of end-stage renal disease.
Study assessed the effects of sotagliflozin vs placebo with respect to glycemic control and the occurrence of severe hypoglycemia and diabetic ketoacidosis among adults with type 1 diabetes.
Dapagliflozin improves glycemic control in patients with inadequately controlled type 1 diabetes currently taking insulin.
A new study suggests that pancreatic exocrine dysfunction develops after initiation of islet cell autoimmunity, suggesting that exocrine dysfunction is related to diabetes disease pathogenesis itself.
Study aimed to determine the effect of metformin on vascular health in children with T1D and above average weight.
Lower incidence of microalbuminuria was noted with the use of ACE inhibitors vs placebo.
Study finds for the first time that during pregnancy the associations between serum 25OHD concentration and 2 single nucleotide polymorphisms are stronger in mothers of children with T1D.
Adapting open-loop settings that are used by the artificial pancreas algorithm is easily understandable and transparent to both patients and physicians.
With this statement, researchers hope to improve safety and efficacy outcomes, advance technology, and improve patient quality of life and health outcomes.
Overall reduction in HbA1c was higher in people with T2D vs those with T1D.
Daily financial incentives improved glucose monitoring, but not glycemic control.
With a little communication, children with diabetes can still enjoy Halloween festivities.
Twenty-five percent of people with type 2 diabetes and 12% of people with type 1 diabetes had depression.
Although the incidence of severe hypoglycemia has decreased while insulin pump use has increased, a causal relationship has not been established between insulin administration methods and risk of complications from diabetes.
Although continuous glucose monitoring accuracy and safety in preterm infants has been validated in several studies, this approach has never been studied in neonates.
For medicare recipients it is more common to be overtreated than undertreated for diabetes.
Results indicate that blood glucose monitoring should be conducted in hospitalized patients with diabetes.
New monitoring system involves the placement of a small sensor wire beneath the skin surface to continuously monitor glucose levels.
PCI has been linked to increased risk of CHD, mortality, MI, and repeat revascularization in type 1 diabetes.
The 2009 H1N1 swine flu pandemic has been linked to an increased risk of new-onset type 1 diabetes in children.
Glycemic Control in Physically Active Adolescents With T1D: Closed-Loop Control vs Remote Pump in Winter Sports
During a 5-day ski camp, researchers examined closed-loop insulin management vs a remote monitored pump system for glycemic control with the additional challenge of cold and altitude.
More awareness for afib risk factors including age, severity of complications, and glycemic status are needed.
The ADA 2017 Standards of Medical Care in Diabetes focuses on monitoring and pharmacologic approaches for type 1 diabetes management.
High-risk genotypes represent 6.4% of the included study population, but accounted for 61% of all cases of T1D.
Prevalence of celiac disease in type 1 diabetes was higher in girls than in boys.
Compared with insulin glargine, insulin degludec significantly reduced rates of hypoglycemia in patients with either type 1 or type 2 diabetes.
Parents of children with an increased genetic risk for type 1 diabetes had higher level of anxiety.
Patients with assumed monogenic diabetes were examined using a novel 3-part biomarker screening pathway to detect incorrectly diagnosed cases of type 1 diabetes.
Left ventricular function can be improved, but not normalized, in adolescents with type 1 diabetes.
Tentative FDA approval has been granted to Merck's follow-on biologic basal insulin injection.
Long-term differences in HbA1c readings were larger than expected in black vs white patients.
The prevalence of diabetes and impairment in glucose metabolism are noticeably higher in psychiatric patients.
Hand pain, disability, and stiffness were common in long-term type 1 diabetes.
Data from a phase 1 study was presented at the 2017 ADA Scientific Sessions.
Over 3% of study participants with type 1 diabetes also had biopsy-confirmed celiac disease.
New recommendations suggest that frequency of diabetic retinopathy screening should be guided by patients' HbA1c levels.
Although metformin did not improve glycemic control in patients with type 1 diabetes, the treatment did improve cardiovascular disease risk management.
Diabetic ketoacidosis led to fatal demise, preterm birth, and neonatal intensive care unit admissions.
Hypoglycemic episodes, moderate or severe, can effectively and efficiently be managed by nasal glucagon in adult patients with type 1 diabetes.
Mental health and behavioral screenings should be routine part of care for pediatric patients with diabetes
A new point-of-care C peptide test may increase ease and access to testing for patients with type 1 and type 2 diabetes.
In all groups of participants, a lower HbA1c was associated with a better health-related quality of life in type 1 diabetes.
A single session of HIIT can "rapidly reduce" awareness of hypoglycemia in patients with type 1 diabetes.
First look at research to be presented at ADA 2017.
Both mealtime and postmeal faster insulin aspart are noninferior to mealtime conventional insulin aspart, regarding HbA1c change from baseline.
There is a 5% probability of progression from state 1 to state 5 between retinal screenings.
Researchers examined whether within-day glycemic variability plays a role in microvascular complications.
Febuxostat was found to have a modest impact in lowering systolic blood pressure among patients with type 1 diabetes.
Patients with type 1 diabetes had higher mortality rates when admitted for acute myocardial infarction compared with patients with type 2 diabetes.
A randomized controlled trial assessed whether mild lower extremity compression can be safely used in patients with diabetes and concurrent lower extremity edema.
PLGM tied to smaller number of hypoglycemic events; increase in time spent 140 mg/dL
A study sought to determine if a virtual glucose management service can result in improved inpatient glycemic control.
Adjuvant metformin produced a small but nonsignificant decrease in body mass index and insulin dose, but by year 10, no beneficial effects were evident.
Black and Latino youth were less likely to undergo an eye examination for diabetic retinopathy within 6 years of their diagnosis.
The prevalence of complications associated with type 1 and type 2 diabetes diagnosed during childhood and adolescence was compared in a multicenter, observational study.
Age-adjusted diabetes incidence increased for every 1 degree celcius temperature increase.
A study found approximately one-third of people with diabetes were undiagnosed or unaware of the diagnosis.
An update to the ADA's 2017 Standards of Medical Care in Diabetes indicates that, barring contraindication, patients with type 2 diabetes should undergo metformin therapy as first-line treatment.
Insulin types and regimens should be determined on an individual basis since there is insufficient data to support one treatment over another.
Investigators found early signs of kidney disease, retinopathy, arterial stiffness, and hypertension in adolescents with either type 1 or type 2 diabetes.
Children younger than 12 were at an elevated risk of type 1 diabetes.
Endocrinology Advisor Articles
- Efficacy and Safety of Alirocumab in Diabetes Mellitus
- Safety of DPP-IV Inhibitor, Cardiovascular Events After ACS in Type 2 Diabetes
- Sex Hormone Levels May Affect Postmenopausal Heart Disease Risk
- Effect of Fructose, Allulose on Postprandial Glucose Regulation in Type 2 Diabetes
- Transgender Youth Not Willing to Delay Hormone Therapy for Fertility Preservation
- Diabetes Treatments
- Metformin May Decrease Colorectal Cancer Risk Among Males With Diabetes
- SGLT2 Inhibitor, GLP-1 Receptor Agonist Combination Treatment for Type 2 Diabetes: Expert Insights
- Semaglutide May Induce Weight Loss in Type 2 Diabetes Despite BMI
- FDA Clears Omnipod DASH System for Diabetes Management
- Single Blood Sample Highly Predictive for Subsequent Diabetes Diagnosis
- Plasma Methylglyoxal Levels Associated With CVD, Mortality in Type 2 Diabetes
- Adjunctive Metformin for Insulin Resistance in T1D: A Clinical Perspective
- AMA: Federal Government Must Tackle Rising Insulin Prices
- Diabetes Medication Reconciliation May Reduce Risk of ED Visits