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Ticlopidine HCl Tablets
Thromboembolic disorders
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Drug Name:

Ticlopidine HCl Tablets Rx

Generic Name and Formulations:
Ticlopidine HCl 250mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Ticlopidine HCl Tablets:

To reduce the risk of thrombotic stroke in selected patients intolerant of aspirin.

Adult:

250mg twice daily with food.

Children:

Not recommended.

Contraindications:

Hematopoietic disorders including neutropenia, thrombocytopenia, or history of thrombotic thrombocytopenic purpura (TTP). Hemostatic or active bleeding disorders. Severe hepatic impairment.

Warnings/Precautions:

Monitor for hematologic toxicity at baseline, every 2 weeks for the first 3 months, and for 2 weeks after discontinuation; test more frequently if signs of hematological changes occur. Discontinue if neutropenia or TTP occur. Renal or hepatic impairment. Bleeding risk (eg, ulcers). Discontinue 10–14 days before surgery. Hyperlipidemia. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Discontinue anticoagulants, fibrinolytics before use. Avoid aspirin. Potentiates aspirin, NSAIDs, anticoagulants, antipyrine, theophylline. Antacids reduce absorption. May be potentiated by cimetidine. Monitor phenytoin. May antagonize digoxin. Caution with propranolol, drugs that increase risk of bleeding, and drugs metabolized by CYP450.

Pharmacological Class:

Platelet aggregation inhibitor.

Adverse Reactions:

Diarrhea, GI upset, rash, neutropenia, pruritus, dizziness, anorexia, abnormal liver function tests, bleeding complications, hyperlipidemia, TTP, aplastic anemia, agranulocytosis, other blood dyscrasis, jaundice.

Note:

Formerly known under the brand name Ticlid.

How Supplied:

Contact supplier.

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