Subclinical Hypothyroidism May Up Gestational Diabetes Risk

Share this content:

the Endocrinology Advisor take:

Gestational diabetes risk was modestly higher in pregnant women with subclinical hypothyroidism when compared with euthyroid pregnant women, results from a recently published review suggest.

Researchers conducted a search of Medline and Embase databases from their beginning through July 2013 as well as reviewed the references of selected studies. All told, they included six cohort studies with data on 35,350 pregnant women. Of these, 1,216 had subclinical hypothyroidism.

Pregnant women with subclinical hypothyroidism had a considerably higher risk for gestational diabetes vs. euthyroid pregnant women, according to the results.

Including five studies, the pooled unadjusted OR was 1.35 (95% CI, 1.05-1.75). Adjusted estimates, including data from three studies, still signaled an increased risk for gestational diabetes in pregnant women with subclinical hypothyroidism, with a pooled adjusted OR of 1.39 (95% CI, 1.07-1.79).

However, these results did not remain significant in sensitivity analyses.

If baseline risk for gestational diabetes is 5% and subclinical hypothyroidism ups this risk by 50% in women with subclinical hypothyroidism, as compared with euthyroid pregnant women, one extra case of gestational diabetes would occur in every 43 pregnant women with subclinical hypothyroidism, according to the data.

The researchers concluded that further study is needed to shed light on these findings. 

Subclinical Hypothyroidism May Up Gestational Diabetes Risk
Subclinical Hypothyroidism May Up Gestational Diabetes Risk

The association between subclinical hypothyroidism and gestational diabetes is controversial. This review evaluates whether the risk of gestational diabetes is different in pregnant women with subclinical hypothyroidism compared to euthyroid pregnant women.

READ FULL ARTICLE From http://aace.metapress.com/content/b22l787p605572rl/?p=8bbc40c8b0d04a10878a7991431c6210&pi=9
You must be a registered member of Endocrinology Advisor to post a comment.

Sign Up for Free e-Newsletters

CME Focus