Destructive thyroiditis was a frequently observed endocrine immune-related adverse event induced by nivolumab treatment and was significantly associated with the existence of anti-thyroglobulin antibodies and/or anti-thyroid peroxidase antibodies prior to treatment.
Researchers designed a cohort study to examine whether serum thyroid hormone levels within the reference range are predictive factors for developing metabolic syndrome in adults.
Shear wave elastography can be a useful tool in the preliminary diagnostics of parathyroid adenomas.
Treating Moderate to Severe Graves' Orbitopathy: Methylprednisolone Alone vs Combined With Mycophenolate
This study is the first to investigate the efficacy and safety of add-on mycophenolate to methylprednisolone for moderate to severe Graves' orbitopathy.
Levothyroxine treatment did not appear to improve pregnancy outcomes in women with thyroid autoantibodies undergoing in vitro fertilization and embryo transfer.
Antithyroid drug exposure during the first trimester was associated with an increased risk for congenital malformations.
Study raises the question of whether treatment with thyroid hormone replacement for individuals with TSH levels >2.5 mIU/L may be an economical first step in treating unexplained infertility.
Study showed that parathyroid hormone was a significant predictor of lumbar spine bone mineral density Z-score for pseudohypoparathyroidism 1B patients.
Survivors of thyroid cancer have a higher risk of developing age-associated diseases compared with patients who never had cancer, particularly if they were younger than 40 years at the time of diagnosis.
Study aimed to evaluate the benefits of levothytoxine treatment on pregnancy outcomes in subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody.
Investigators aimed to determine strategies for improvement to reduce complications after thyroidectomy.
No clear effect in most cases of a second radioactive iodine (RAI) treatment in patients with differentiated thyroid cancer with biochemical or structural regional incomplete response to initial thyroidectomy and RAI therapy.
Thyroid ultrasonography, which may lead to the discovery of incidental nodules, anxiety, and high cost, is not required in evaluation for hypothyroidism.
The transoral endoscopic thyroidectomy vestibular approach can be a safe procedure in select patients, with outcomes similar to those of open thyroidectomy.
A 6.2-fold variation in thyroidectomy rates was noted throughout the US.
Both over- and undertreatment of congenital hypothyroidism can result in negative behavioral outcomes.
No regional or distant metastases developed during active surveillance in low-risk patients.
Irregular users of thyroxine were less likely to develop thyroid cancer compared to regular users.
Stroke risk with I-131 therapy for thyroid cancer was examined via 2 cohorts using 1:1 propensity score matching.
Maternal thyroid function and weight gain in early pregnancy were associated with hypothyroidism, but not hyperthyroidism.
Relapse risk was highest among patients with hypothyroidism.
After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.
Adult patients with obesity and hypothyroidism have lower-than-average sleep oxygen saturation.
Patients given teprotumumab were more likely to experience a response at 24 weeks vs placebo.
Thyroid cancer screening in asymptomatic adults was given a D recommendation because of the negative effects of screening outweighing any benefits.
Miscarriage risk before 20 weeks of gestation is higher among women with untreated subclinical hypothyroidism.
Data were collected from the Nurses' Health Study I to examine the relationship between BMI and primary hyperparathyroidism risk.
Patients with government subsidized or self-pay insurance were less likely to undergo thyroidectomy for thyroid cancer.
Increases in papillary thyroid cancer were most common between 1974 and 2013.
The pocket references and mobile apps will be updated as diagnostic tools and guidelines continue to improve.
Tirosint-SOL (levothyroxine sodium oral solution) should be available within the next 6 months.
The drug's approval was based on 2 successful phase 3 trials.
Women with subclinical hypothyroidism who undergo thyroid hormone treatment have a decreased risk of pregnancy loss, but may experience other pregnancy-related adverse outcomes.
Younger survivors of thyroid cancer are at increased risk for certain types of health problems later in life.
For patients with unresected anaplastic thyroid carcinoma, overall survival is poor, but radiation therapy dose is associated with improved survival.
Early detection and quick treatment with levothyroxine are essential in treating children with congenital hypothyroidism.
For patients with head and neck cancer receiving radiotherapy, thyroid dysfunction is a dose-related complication, with increased risk for female sex and concurrent chemotherapy.
Patients with fibromyalgia syndrome have high prevalence of anti-thyroid-stimulating hormone (TSH) receptor antibody (TRAb).
Widespread routine thyroid cancer screening can lead to overdiagnosis and overtreatment, according to the statement.
Aryl hydrocarbon receptor (AHR) and AHR ligands prevent formation of transforming growth factor (TGF)-β-dependent myofibroblast formation in thyroid eye disease.
In a 2-phase study of patients with autoimmune thyroid disease, researchers identified specific antibodies that may have lead to an elevated risk of autoimmune disorder development.
Does core-needle biopsy perform better than repeat fine-needle aspiration for evaluating thyroid nodules?
Researchers hypothesize that thyroid function affects dementia risk through nonvascular pathways.
SREAT, or Hashimoto's encephalopathy, may present in some cases with purely depressive symptoms.
Patients with thyroid hormone levels on the high end of the normal range in this study were more than twice as likely to die of sudden cardiac arrest.
Primary care physicians play an important role in identifying thyroid disease in children and adolescents, according to a review published in JAMA Pediatrics.
Researchers have identified estimates for risk of occult nodal disease of patients with papillary thyroid cancer who have undergone surgery.
More imaging tests after treatment does not always lead to an improvement in thyroid cancer patients' chances of survival.
Lower thyroid function was associated with a 1.24-fold higher risk for nonalcoholic fatty liver disease.
There were no effective therapeutic options for advanced thyroid cancer until 5 years ago.
Physicians present viewpoints for and against treatment of subclinical hypothyroidism in a 60-year-old patient.
A uniform standard for thyroid-stimulating hormone reference limits could lead to frequent misclassification and incorrect choices for therapy.
The recent increase may be caused by an 'epidemic of diagnosis,' not harmful tumors, researchers said.
Local-regional failure in well-differentiated thyroid cancer mostly occurs outside of 70 Gy volume and in peri-esophageal region.
The risk for complications was 87% higher when a surgeon's case load is1 thyroidectomy case a year.
However, nearly one-third of patients develop lifelong complications following thyroid surgery.
The use of certain antiepileptic drugs may cause alterations in thyroid hormone levels in patients with epilepsy.
The large study linking Agent Orange with adverse effects includes US veterans of the Korean War who also served in the Vietnam War.
Women with hyperthyroidism have increased breast cancer risk, while hypothyroidism is associated with decreased risk.
The likelihood of developing breast or thyroid cancer as a secondary malignancy is increased following diagnosis of the other cancer.
In the elderly, subclinical hypothyroidism is not associated with significantly increased risk for recurrent venous thromboembolism.
Patients with thyroid cancer report worse quality of life than others diagnosed with more lethal cancers.
Results from the HUNT Study in Norway found an association between autoimmune diabetes and thyroid dysfunction.
The FDA has issued a drug safety communication regarding iodine-containing contrast agents in infants.
Rates lower for surgeons performing 25 or more total thyroidectomies a year.
Excellent accuracy for 10-year disease-specific death, recurrence.
Positive link to papillary, follicular, anaplastic thyroid cancer; inverse link for medullary thyroid cancer.
Many cases involve low-risk tumors where treatments could carry greater risks than benefits.
Volume reduction and symptom improvement found after treatment.
Recombinant human TSH avoids transient health-related quality-of-life deterioration seen with thyroid hormone withdrawal.
Cervical lymph node metastases are associated with compromised survival in young patients with papillary thyroid cancer.
Acupuncture may be an effective treatment for patients with thyroid cancer who experience radioactive-iodine-induced (RAI)-induced anorexia.
HABP2 G534E variant is a susceptibility gene for familial nonmedullary thyroid cancer and functions as a dominant-negative tumor-suppressor gene.
New developments in molecular profiling have been included in an updated position statement on thyroid cancer.
No increased risk for patients with hypothyroidism treated with thyroid hormone replacement therapy.
Researchers found greater risk of hip and other fractures with subclinical hyperthyroidism.
The American Thyroid Association has released the first guidelines for evaluating and managing thyroid nodules and thyroid cancer in pediatric patients.
Thyrotropin levels within the reference range do not appear to be linked to risk for CHD events and CHD mortality.
After 5 years, less than 1% of asymptomatic nodules studied were diagnosed as thyroid cancer.
British study finds an association, but unable to prove cause-and-effect.
Drug approved to treat progressive, differentiated thyroid cancer that is refractory to radioactive iodine therapy.
Lenvatinib improved progression-free survival and response rate in I-131-refractory thyroid cancer.
Thyroid disease, including hyperthyroidism and hypothyroidism, may be linked to fertility problems and miscarriages in women.
In a randomized, double-blind study, Rituximab was more effective in treating Graves' orbitopathy than intravenous methylprednisolone.
Radiation effects on thyroid nodules were noted in people who survived the atomic bombings at Hiroshima and Nagasaki.
A number of factors contribute to the need for higher-than-expected levothyroxine dosing requirements in patients with hypothyroidism.
Higher TSH and lower FT4 thyroid hormone levels are associated with decreased risk for adverse effects in older adults.
Maximum tumor size may predict outcomes after treatment with sorafenib in radioactive iodine-refractory differentiated thyroid cancer.
A next-generation sequencing panel of genetic markers may improve cancer diagnosis of indeterminate thyroid nodules.
Thyroid-specific autoantibody levels did not predict clinical features of Graves' disease, including ophthalmopathy or goiter.
Sex hormones may account for the differences between men and women in the development of follicular thyroid cancer.
A blood assay that measures BRAF mutation levels may be helpful in diagnosing and monitoring papillary thyroid cancer.
Only moderate suppression of thyroid-stimulating hormone improves outcomes in all stages of differentiated thyroid cancer.
Women should likely discontinue methimazole during pregnancy to prevent complications.
Radioactive iodine therapy may slightly improve survival in papillary thyroid carcinoma.
Combining Lithium With Radioactive Iodine Therapy for Metastatic Radioiodine-Refractory Thyroid Cancer
Combining lithium with radioactive iodine therapy may improve survival in patients with metastatic radioiodine-refractory thyroid cancer.
Rituximab did not perform better than a placebo in treating Graves' orbitopathy in a randomized controlled trial.
The U.S. Preventive Services Task Force states that more evidence is needed to adequately assess the benefits or harms of thyroid screening.
Richard Quinton, MD, offers his take on these study findings and what they may mean for clinical practice.
The endocrine-disrupting chemical polychlorinated biphenyls may enter the placenta and affect thyroid hormone action during pregnancy.
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