Thyroid Archive

Sleep Disordered Breathing Impacted by Hypothyroidism, Obesity

Sleep Disordered Breathing Impacted by Hypothyroidism, Obesity

Adult patients with obesity and hypothyroidism have lower-than-average sleep oxygen saturation.

Active Ophthalmopathy Benefits From Teprotumumab Treatment

Active Ophthalmopathy Benefits From Teprotumumab Treatment

Patients given teprotumumab were more likely to experience a response at 24 weeks vs placebo.

USPSTF: No Thyroid Cancer Screening in Asymptomatic Adults

USPSTF: No Thyroid Cancer Screening in Asymptomatic Adults

Thyroid cancer screening in asymptomatic adults was given a D recommendation because of the negative effects of screening outweighing any benefits.

Subclinical Hypothyroidism Increased Risk for Miscarriage

Subclinical Hypothyroidism Increased Risk for Miscarriage

Miscarriage risk before 20 weeks of gestation is higher among women with untreated subclinical hypothyroidism.

Increased Primary Hyperparathyoridism Risk Linked to Weight in Women

Increased Primary Hyperparathyoridism Risk Linked to Weight in Women

Data were collected from the Nurses' Health Study I to examine the relationship between BMI and primary hyperparathyroidism risk.

Health Care Reform Increases Thyroidectomy Rates for Thyroid Cancer

Health Care Reform Increases Thyroidectomy Rates for Thyroid Cancer

Patients with government subsidized or self-pay insurance were less likely to undergo thyroidectomy for thyroid cancer.

Incidence Of, Mortality From Thyroid Cancer Increased in US

Incidence Of, Mortality From Thyroid Cancer Increased in US

Increases in papillary thyroid cancer were most common between 1974 and 2013.

American Thyroid Association Releases Guidelines As Mobile Apps, Pocket Reference Cards

American Thyroid Association Releases Guidelines As Mobile Apps, Pocket Reference Cards

The pocket references and mobile apps will be updated as diagnostic tools and guidelines continue to improve.

FDA: Levothyroxine Liquid Formulation Approved for Hypothyroidism

FDA: Levothyroxine Liquid Formulation Approved for Hypothyroidism

Tirosint-SOL (levothyroxine sodium oral solution) should be available within the next 6 months.

Risk of Pregnancy Loss in Subclinical Hypothyroidism

Risk of Pregnancy Loss in Subclinical Hypothyroidism

Women with subclinical hypothyroidism who undergo thyroid hormone treatment have a decreased risk of pregnancy loss, but may experience other pregnancy-related adverse outcomes.

Heart Disease, Osteoporosis Risks Up in Young Thyroid Cancer Survivors

Heart Disease, Osteoporosis Risks Up in Young Thyroid Cancer Survivors

Younger survivors of thyroid cancer are at increased risk for certain types of health problems later in life.

Unresected Anaplastic Thyroid Cancer Linked to Poor Overall Survival

Unresected Anaplastic Thyroid Cancer Linked to Poor Overall Survival

For patients with unresected anaplastic thyroid carcinoma, overall survival is poor, but radiation therapy dose is associated with improved survival.

Study Assesses Treatment Dose, Timing of Levothyroxine in Congenital Hypothyroidism

Study Assesses Treatment Dose, Timing of Levothyroxine in Congenital Hypothyroidism

Early detection and quick treatment with levothyroxine are essential in treating children with congenital hypothyroidism.

Thyroid Dysfunction Related to Radiation Dose in Head and Neck Cancer

Thyroid Dysfunction Related to Radiation Dose in Head and Neck Cancer

For patients with head and neck cancer receiving radiotherapy, thyroid dysfunction is a dose-related complication, with increased risk for female sex and concurrent chemotherapy.

High Prevalence of Anti-TSH Receptor Antibody in Fibromyalgia

High Prevalence of Anti-TSH Receptor Antibody in Fibromyalgia

Patients with fibromyalgia syndrome have high prevalence of anti-thyroid-stimulating hormone (TSH) receptor antibody (TRAb).

USPSTF Still Recommending Against Routine Thyroid Cancer Screening

USPSTF Still Recommending Against Routine Thyroid Cancer Screening

Widespread routine thyroid cancer screening can lead to overdiagnosis and overtreatment, according to the statement.

AHR Ligands May Be Beneficial in Thyroid Eye Disease

AHR Ligands May Be Beneficial in Thyroid Eye Disease

Aryl hydrocarbon receptor (AHR) and AHR ligands prevent formation of transforming growth factor (TGF)-β-dependent myofibroblast formation in thyroid eye disease.

Link Between Autoimmune Thyroid Disease, Nonorgan-Specific Antibodies

Link Between Autoimmune Thyroid Disease, Nonorgan-Specific Antibodies

In a 2-phase study of patients with autoimmune thyroid disease, researchers identified specific antibodies that may have lead to an elevated risk of autoimmune disorder development.

Core-Needle Biopsy vs Fine-Needle Aspiration for Thyroid Nodules

Core-Needle Biopsy vs Fine-Needle Aspiration for Thyroid Nodules

Does core-needle biopsy perform better than repeat fine-needle aspiration for evaluating thyroid nodules?

Thyroid Hormone Levels May Affect Risk for Dementia

Thyroid Hormone Levels May Affect Risk for Dementia

Researchers hypothesize that thyroid function affects dementia risk through nonvascular pathways.

An Uncommon Presentation of Hashimoto's Encelophathy

An Uncommon Presentation of Hashimoto's Encelophathy

SREAT, or Hashimoto's encephalopathy, may present in some cases with purely depressive symptoms.

Higher Thyroid Levels Tied to Risk for Sudden Cardiac Death

Higher Thyroid Levels Tied to Risk for Sudden Cardiac Death

Patients with thyroid hormone levels on the high end of the normal range in this study were more than twice as likely to die of sudden cardiac arrest.

Identifying Pediatric Thyroid Disease Often Falls on Primary Care Physicians

Identifying Pediatric Thyroid Disease Often Falls on Primary Care Physicians

Primary care physicians play an important role in identifying thyroid disease in children and adolescents, according to a review published in JAMA Pediatrics.

Study Identifies Risk Estimates for Occult Nodal Disease After Thyroidectomy

Study Identifies Risk Estimates for Occult Nodal Disease After Thyroidectomy

Researchers have identified estimates for risk of occult nodal disease of patients with papillary thyroid cancer who have undergone surgery.

Imaging After Thyroid Cancer Treatment May Not Improve Survival

Imaging After Thyroid Cancer Treatment May Not Improve Survival

More imaging tests after treatment does not always lead to an improvement in thyroid cancer patients' chances of survival.

Nonalcoholic Fatty Liver Disease Risk Higher With Hypothyroidism

Nonalcoholic Fatty Liver Disease Risk Higher With Hypothyroidism

Lower thyroid function was associated with a 1.24-fold higher risk for nonalcoholic fatty liver disease.

Impact of Drug, Genomic Innovations on Thyroid Cancer Treatment

Impact of Drug, Genomic Innovations on Thyroid Cancer Treatment

There were no effective therapeutic options for advanced thyroid cancer until 5 years ago.

Physician Opinions Vary Regarding Management of Subclinical Hypothyroidism

Physician Opinions Vary Regarding Management of Subclinical Hypothyroidism

Physicians present viewpoints for and against treatment of subclinical hypothyroidism in a 60-year-old patient.

TSH Reference Limits Vary During First Trimester of Pregnancy

TSH Reference Limits Vary During First Trimester of Pregnancy

A uniform standard for thyroid-stimulating hormone reference limits could lead to frequent misclassification and incorrect choices for therapy.

Thyroid Cancer Rates Leveling Off

Thyroid Cancer Rates Leveling Off

The recent increase may be caused by an 'epidemic of diagnosis,' not harmful tumors, researchers said.

Thyroid Cancer Progression Slowed With Dose Escalation of IMRT

Thyroid Cancer Progression Slowed With Dose Escalation of IMRT

Local-regional failure in well-differentiated thyroid cancer mostly occurs outside of 70 Gy volume and in peri-esophageal region.

Complications After Thyroidectomy Less Likely With High-Volume Surgeons

Complications After Thyroidectomy Less Likely With High-Volume Surgeons

The risk for complications was 87% higher when a surgeon's case load is1 thyroidectomy case a year.

Study: Survival Is 'Excellent' in Pediatric Differentiated Thyroid Cancer

Study: Survival Is 'Excellent' in Pediatric Differentiated Thyroid Cancer

However, nearly one-third of patients develop lifelong complications following thyroid surgery.

Antiepileptic Drugs May Affect Thyroid Hormone Levels

Antiepileptic Drugs May Affect Thyroid Hormone Levels

The use of certain antiepileptic drugs may cause alterations in thyroid hormone levels in patients with epilepsy.

Agent Orange Herbicide Linked to Hypothyroidism and Bladder Cancer

Agent Orange Herbicide Linked to Hypothyroidism and Bladder Cancer

The large study linking Agent Orange with adverse effects includes US veterans of the Korean War who also served in the Vietnam War.

Breast Cancer Risk Varied With Thyroid Function Level

Breast Cancer Risk Varied With Thyroid Function Level

Women with hyperthyroidism have increased breast cancer risk, while hypothyroidism is associated with decreased risk.

Thyroid Cancer Risk Up After Breast Cancer

Thyroid Cancer Risk Up After Breast Cancer

The likelihood of developing breast or thyroid cancer as a secondary malignancy is increased following diagnosis of the other cancer.

Subclinical Hypothyroidism Not Linked to Venous Thromboembolism Risk in Elderly

Subclinical Hypothyroidism Not Linked to Venous Thromboembolism Risk in Elderly

In the elderly, subclinical hypothyroidism is not associated with significantly increased risk for recurrent venous thromboembolism.

Thyroid Cancer Survivors Report Poor Quality of Life

Thyroid Cancer Survivors Report Poor Quality of Life

Patients with thyroid cancer report worse quality of life than others diagnosed with more lethal cancers.

Thyroid Dysfunction Associated With Autoimmune Diabetes

Thyroid Dysfunction Associated With Autoimmune Diabetes

Results from the HUNT Study in Norway found an association between autoimmune diabetes and thyroid dysfunction.

FDA: Reports of Underactive Thyroid in Infants After Iodinated Contrast Media Use

FDA: Reports of Underactive Thyroid in Infants After Iodinated Contrast Media Use

The FDA has issued a drug safety communication regarding iodine-containing contrast agents in infants.

Complication Rates After Thyroidectomy Lower With High-Volume Surgeons

Complication Rates After Thyroidectomy Lower With High-Volume Surgeons

Rates lower for surgeons performing 25 or more total thyroidectomies a year.

New Nomogram Predicts Death, Recurrence Risk in Papillary Thyroid Cancer

New Nomogram Predicts Death, Recurrence Risk in Papillary Thyroid Cancer

Excellent accuracy for 10-year disease-specific death, recurrence.

Obesity May Raise Thyroid Cancer Risk

Obesity May Raise Thyroid Cancer Risk

Positive link to papillary, follicular, anaplastic thyroid cancer; inverse link for medullary thyroid cancer.

Advanced Imaging May Account for Increase in Thyroid Cancer Detection

Advanced Imaging May Account for Increase in Thyroid Cancer Detection

Many cases involve low-risk tumors where treatments could carry greater risks than benefits.

Laser Ablation Therapy Safe, Effective for Benign Thyroid Nodules

Laser Ablation Therapy Safe, Effective for Benign Thyroid Nodules

Volume reduction and symptom improvement found after treatment.

Recombinant TSH Better After Thyroid Cancer Radioiodine Ablation

Recombinant TSH Better After Thyroid Cancer Radioiodine Ablation

Recombinant human TSH avoids transient health-related quality-of-life deterioration seen with thyroid hormone withdrawal.

Cervical Lymph Node Metastases Linked to Lower Survival in Thyroid Cancer

Cervical Lymph Node Metastases Linked to Lower Survival in Thyroid Cancer

Cervical lymph node metastases are associated with compromised survival in young patients with papillary thyroid cancer.

In Thyroid Cancer, Acupuncture May Effectively Treat Radioactive Iodine-Induced Anorexia

In Thyroid Cancer, Acupuncture May Effectively Treat Radioactive Iodine-Induced Anorexia

Acupuncture may be an effective treatment for patients with thyroid cancer who experience radioactive-iodine-induced (RAI)-induced anorexia.

HABP2 Mutation Confers Susceptibility to Thyroid Cancer

HABP2 Mutation Confers Susceptibility to Thyroid Cancer

HABP2 G534E variant is a susceptibility gene for familial nonmedullary thyroid cancer and functions as a dominant-negative tumor-suppressor gene.

Molecular Testing Advances Prompt Updated Thyroid Cancer Guidelines

Molecular Testing Advances Prompt Updated Thyroid Cancer Guidelines

New developments in molecular profiling have been included in an updated position statement on thyroid cancer.

Hypothyroidism Linked to Diabetes Risk

Hypothyroidism Linked to Diabetes Risk

No increased risk for patients with hypothyroidism treated with thyroid hormone replacement therapy.

Subclinical Hyperthyroidism Raises Fracture Risk

Subclinical Hyperthyroidism Raises Fracture Risk

Researchers found greater risk of hip and other fractures with subclinical hyperthyroidism.

ATA Releases First Guidelines for Thyroid Nodules, Thyroid Cancer in Children

ATA Releases First Guidelines for Thyroid Nodules, Thyroid Cancer in Children

The American Thyroid Association has released the first guidelines for evaluating and managing thyroid nodules and thyroid cancer in pediatric patients.

Higher Reference-Range Thyrotropin Levels Not Associated With CHD Risk

Higher Reference-Range Thyrotropin Levels Not Associated With CHD Risk

Thyrotropin levels within the reference range do not appear to be linked to risk for CHD events and CHD mortality.

Benign Thyroid Nodules May Require Less Aggressive Follow-Up

Benign Thyroid Nodules May Require Less Aggressive Follow-Up

After 5 years, less than 1% of asymptomatic nodules studied were diagnosed as thyroid cancer.

Hypothyroidism Associated With Water Fluoridation in Britain

Hypothyroidism Associated With Water Fluoridation in Britain

British study finds an association, but unable to prove cause-and-effect.

Lenvima Wins FDA Approval for Advanced Thyroid Cancer

Lenvima Wins FDA Approval for Advanced Thyroid Cancer

Drug approved to treat progressive, differentiated thyroid cancer that is refractory to radioactive iodine therapy.

Lenvatinib Improved Survival in I-131-Refractory Thyroid Cancer

Lenvatinib Improved Survival in I-131-Refractory Thyroid Cancer

Lenvatinib improved progression-free survival and response rate in I-131-refractory thyroid cancer.

Thyroid Disease May Adversely Affect Women's Reproductive Health

Thyroid Disease May Adversely Affect Women's Reproductive Health

Thyroid disease, including hyperthyroidism and hypothyroidism, may be linked to fertility problems and miscarriages in women.

Rituximab Bests Methylprednisolone in Graves' Orbitopathy

Rituximab Bests Methylprednisolone in Graves' Orbitopathy

In a randomized, double-blind study, Rituximab was more effective in treating Graves' orbitopathy than intravenous methylprednisolone.

Radiation Effects on Thyroid Nodules in Atomic Bomb Survivors

Radiation Effects on Thyroid Nodules in Atomic Bomb Survivors

Radiation effects on thyroid nodules were noted in people who survived the atomic bombings at Hiroshima and Nagasaki.

Factors Contributing to High Levothyroxine Doses

Factors Contributing to High Levothyroxine Doses

A number of factors contribute to the need for higher-than-expected levothyroxine dosing requirements in patients with hypothyroidism.

Fewer Adverse Events for Elderly with High TSH, Low FT4

Fewer Adverse Events for Elderly with High TSH, Low FT4

Higher TSH and lower FT4 thyroid hormone levels are associated with decreased risk for adverse effects in older adults.

Prognostic Factors of Sorafenib Treatment Outcomes Identified

Prognostic Factors of Sorafenib Treatment Outcomes Identified

Maximum tumor size may predict outcomes after treatment with sorafenib in radioactive iodine-refractory differentiated thyroid cancer.

Next-Generation Sequencing Test Promising for Diagnosis of Indeterminate Thyroid Nodules

Next-Generation Sequencing Test Promising for Diagnosis of Indeterminate Thyroid Nodules

A next-generation sequencing panel of genetic markers may improve cancer diagnosis of indeterminate thyroid nodules.

Thyroid Antibody Levels Not Predictive of Clinical Manifestations of Graves' Disease

Thyroid Antibody Levels Not Predictive of Clinical Manifestations of Graves' Disease

Thyroid-specific autoantibody levels did not predict clinical features of Graves' disease, including ophthalmopathy or goiter.

Sex Hormones May Play Role in Follicular Thyroid Cancer

Sex Hormones May Play Role in Follicular Thyroid Cancer

Sex hormones may account for the differences between men and women in the development of follicular thyroid cancer.

New Assay May Help Guide Therapy in Papillary Thyroid Cancer

New Assay May Help Guide Therapy in Papillary Thyroid Cancer

A blood assay that measures BRAF mutation levels may be helpful in diagnosing and monitoring papillary thyroid cancer.

Moderate Thyroid Hormone Suppression Superior in Thyroid Cancer

Moderate Thyroid Hormone Suppression Superior in Thyroid Cancer

Only moderate suppression of thyroid-stimulating hormone improves outcomes in all stages of differentiated thyroid cancer.

Methimazole Exposure Linked to Higher Pregnancy Complication Rate

Methimazole Exposure Linked to Higher Pregnancy Complication Rate

Women should likely discontinue methimazole during pregnancy to prevent complications.

Radioiodine Has Small Benefit in Papillary Thyroid Cancer

Radioiodine Has Small Benefit in Papillary Thyroid Cancer

Radioactive iodine therapy may slightly improve survival in papillary thyroid carcinoma.

Combining Lithium With Radioactive Iodine Therapy for Metastatic Radioiodine-Refractory Thyroid Cancer

Combining Lithium With Radioactive Iodine Therapy for Metastatic Radioiodine-Refractory Thyroid Cancer

Combining lithium with radioactive iodine therapy may improve survival in patients with metastatic radioiodine-refractory thyroid cancer.

Rituximab Not Effective in Graves' Orbitopathy

Rituximab Not Effective in Graves' Orbitopathy

Rituximab did not perform better than a placebo in treating Graves' orbitopathy in a randomized controlled trial.

USPSTF: Insufficient Evidence on Thyroid Screening

USPSTF: Insufficient Evidence on Thyroid Screening

The U.S. Preventive Services Task Force states that more evidence is needed to adequately assess the benefits or harms of thyroid screening.

Post-Thyroidectomy Hypocalcemia Predictors Identified

Post-Thyroidectomy Hypocalcemia Predictors Identified

Richard Quinton, MD, offers his take on these study findings and what they may mean for clinical practice.

Endocrine-Disrupting Chemicals Affect Thyroid Hormone Activity in Pregnancy

Endocrine-Disrupting Chemicals Affect Thyroid Hormone Activity in Pregnancy

The endocrine-disrupting chemical polychlorinated biphenyls may enter the placenta and affect thyroid hormone action during pregnancy.

ATA: Levothyroxine Should Remain Standard of Care for Hypothyroidism

ATA: Levothyroxine Should Remain Standard of Care for Hypothyroidism

An expert panel reviewing treatments for hypothyroidism has concluded that the drug levothyroxine should remain the standard of care.

Liquid Levothyroxine May Prevent Malabsorption From Proton-Pump Inhibitors

Liquid Levothyroxine May Prevent Malabsorption From Proton-Pump Inhibitors

An oral levothyroxine solution bested the tablet form in preventing malabsorption related to proton-pump inhibitors.

Low-Activity I-131 Not Optimal in Differentiated Thyroid Cancer

Low-Activity I-131 Not Optimal in Differentiated Thyroid Cancer

Radioactive iodine therapy with low-activity I-131 may result in worse survival and more radiation exposure in patients with differentiated thyroid cancer.

TSH in First Trimester Not Indicative of Adverse Pregnancy Outcomes

TSH in First Trimester Not Indicative of Adverse Pregnancy Outcomes

Mild hypothyroidism in women may not be linked to adverse outcomes in pregnancy.

Metformin May Lower TSH in Hypothyroidism

Metformin May Lower TSH in Hypothyroidism

Metformin may raise the risk for low levels of thyroid-stimulating hormone among patients with hypothyroidism.

Thyroid, Renal Cancers Increasing in Children

Thyroid, Renal Cancers Increasing in Children

The incidence of renal cancer and thyroid cancer is increasing among children and adolescents in the United States.

Thyroid Cancer, Nodular Disease Risk Increased in Acromegaly

Thyroid Cancer, Nodular Disease Risk Increased in Acromegaly

Thyroid nodular disease and thyroid cancer prevalence appears to be higher in patients with acromegaly.

Pediatric Thyroid Cancer Patients Require Long-Term Follow-Up

Pediatric Thyroid Cancer Patients Require Long-Term Follow-Up

Long-term follow-up is important in children with thyroid cancer to prevent late recurrence.

Subclinical Hypothyroidism Not Linked to Stroke Risk

Subclinical Hypothyroidism Not Linked to Stroke Risk

Ischemic stroke risk does not appear to be elevated in postmenopausal women with subclinical hypothyroidism.

Subclinical Hypothyroidism May Up Gestational Diabetes Risk

Subclinical Hypothyroidism May Up Gestational Diabetes Risk

Gestational diabetes risk is modestly higher in pregnant women with subclinical hypothyroidism when compared with euthyroid pregnant women.

Oral Solution Improved Levothyroxine Absorption in Hypothyroidism

Oral Solution Improved Levothyroxine Absorption in Hypothyroidism

Levothyroxine absorption may be increased when administered as an oral solution, as compared with tablets, in hypothyroidism.

Miscarriage Risk May Rise With Thyroid-Stimulating Hormone Levels

Miscarriage Risk May Rise With Thyroid-Stimulating Hormone Levels

Women with high thyroid-stimulating hormone levels during pregnancy may have an increased risk for miscarriage.

Lenvatinib Promising for Radioiodine-Resistant Thyroid Cancer

Lenvatinib Promising for Radioiodine-Resistant Thyroid Cancer

Lenvatinib, a new TKI inhibitor, delays disease progression and shows promising clinical efficacy against differentiated radioiodine-resistant thyroid cancer.

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