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STARLIX
Diabetes
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Drug Name:

STARLIX Rx

Generic Name and Formulations:
Nateglinide 60mg, 120mg; tabs.

Company:
Novartis Pharmaceuticals Corp

Therapeutic Use:

Indications for STARLIX:

Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Limitations Of use:

Not for treatment of type 1 diabetes or diabetic ketoacidosis.

Adult:

Take 1–30mins before meals; skip dose if meal is skipped. 120mg 3 times daily. If near glycemic goal, initially 60mg 3 times daily.

Children:

Not established.

Warnings/Precautions:

Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. Reduced symptomatic awareness of hypoglycemia in longstanding diabetes, diabetic nerve disease, or recurrent hypoglycemia. Moderate-to-severe hepatic impairment. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Increased hypoglycemia with concomitant other antidiabetic agents, NSAIDs, salicylates, MAOIs, non-selective β-blockers, anabolic hormones, guanethidine, and CYP2C9 inhibitors (eg, amiodarone, fluconazole, voriconazole, sulfinpyrazone), alcohol; may need dose reduction and monitor. May be antagonized by thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogs (eg, lanreotide, octreotide), and CYP inducers (eg, rifampin, phenytoin, St John's Wort); may need dose increase and monitor. β-blockers, clonidine, guanethidine, reserpine may mask hypoglycemia.

Pharmacological Class:

Glinide.

Adverse Reactions:

Upper RTI, back pain, flu symptoms, dizziness, arthropathy, diarrhea; hypoglycemia, weight gain.

How Supplied:

Tabs—100

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