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RYANODEX
Inborn errors of metabolism
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Drug Name:

RYANODEX Rx

Generic Name and Formulations:
Dantrolene sodium 250mg; per vial; lyophilized pwd for IV inj after reconstitution.

Company:
Eagle Pharmaceuticals

Therapeutic Use:

Indications for RYANODEX:

Treatment of malignant hyperthermia (MH) in conjunction with appropriate supportive measures. Prevention of malignant hyperthermia in high-risk patients.

Adults and Children:

Treatment: Give by IV push at a minimum of 1mg/kg; if psychologic and metabolic abnormalities continues or reappear, repeat dosing; max cumulative dose: 10mg/kg. Prevention: Start approx. 75 mins prior to surgery. 2.5mg/kg by IV over ≥1 min; may give additional doses if surgery prolonged.

Warnings/Precautions:

Institute supportive measures (eg, discontinue MH-triggering agents, manage metabolic acidosis, cooling if necessary, diuretic administration). Monitor for skeletal muscle weakness, adequate ventilation, difficulty swallowing and choking. Avoid extravasation. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid MH-triggering agents. Increased risk of somnolence or dizziness with concomitant sedative agents. Concomitant calcium channel blockers: not recommended. Concomitant other muscle relaxants may potentiate neuromuscular block. Increased CNS effects with concomitant antipsychotics, anxiolytics.

Pharmacological Class:

Muscle relaxant (skeletal).

Adverse Reactions:

Loss of grip strength, weakness in the legs, drowsiness, flushing, somnolence, dizziness, nausea, thrombophlebitis, tissue necrosis secondary to extravasation, urticaria, inj site reactions (eg, pain, erythema, swelling); dyspnea, dysphasia.

How Supplied:

Single-use vial (20mL)—1 (w. diluent)

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