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Prochlorperazine
Anxiety/OCD
Nausea
Psychosis
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Drug Name:

Prochlorperazine Rx

Generic Name and Formulations:
Prochlorperazine (as maleate) 5mg, 10mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Prochlorperazine:

Short-term generalized anxiety.

Adult:

5mg 3–4 times daily; max 20mg/day. Do not use >12 weeks.

Children:

Not recommended.

Contraindications:

Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.

Pharmacological Class:

Piperazine phenothiazine.

Adverse Reactions:

Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.

Note:

Formerly known under the brand name Compazine.

How Supplied:

Contact supplier.

Indications for Prochlorperazine:

Severe nausea and vomiting.

Adult:

Oral: 5–10mg 3–4 times daily; usual max 40mg/day. Rectal: 25mg twice daily.

Children:

<2yrs or <20lbs: not recommended. Oral: 20–29lbs: 2½mg once or twice daily; max 7.5mg/day. 30–39lbs: 2½mg 2–3 times daily; max 10mg/day. 40–85lbs: 2½mg 3 times daily or 5mg twice daily; max 15mg/day.

Contraindications:

Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.

See Also:

Prochlorperazine Suppositories

Pharmacological Class:

Piperazine phenothiazine.

Adverse Reactions:

Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.

Note:

Formerly known under the brand name Compazine.

How Supplied:

Contact supplier.

Indications for Prochlorperazine:

Schizophrenia.

Adult:

Mild conditions: 5–10mg 3–4 times daily. Moderate-to-severe conditions (closely supervised): Initially 10mg 3–4 times daily, may increase gradually every 2–3 days; usual range 50–75mg/day. Severe conditions: usual range 100–150mg daily.

Children:

<2yrs or <20lbs: not recommended. 2yrs–5yrs: Initially 2.5mg 2–3 times daily; max 10mg first day, then max 20mg/day. 6–12yrs: Initially 2.5mg 2–3 times daily; max 10mg first day, then max 25mg/day.

Contraindications:

Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.

Pharmacological Class:

Piperazine phenothiazine.

Adverse Reactions:

Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.

Note:

Formerly known under the brand name Compazine.

How Supplied:

Contact supplier.

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