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Prednisolone Sodium Phosphate Oral Solution 25mg/5mL
Corticosteroid-responsive disorders
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Drug Name:

Prednisolone Sodium Phosphate Oral Solution 25mg/5mL Rx

Generic Name and Formulations:
Prednisolone 25mg/5mL; grape flavored.

Company:
Mission Pharmacal Company

Therapeutic Use:

Indications for Prednisolone Sodium Phosphate Oral Solution 25mg/5mL:

Corticosteroid-responsive disorders.

Adult:

See full labeling. Initially 5–60mg daily.

Children:

See full labeling. Initially 0.14–2mg/kg/day in 3 or 4 divided doses.

Contraindications:

Systemic fungal infections. Live vaccines.

Warnings/Precautions:

Systemic fungal infections, cerebral malaria, optic neuritis: not recommended. Tuberculosis. Latent amebiasis. Strongyloides infestation. Ocular herpes simplex. May increase risk and mask signs of infection. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. HPA axis suppression. Cushing’s syndrome. Hyperglycemia. Thyroid disorders. Hypertension. CHF. Renal insufficiency. Recent MI. Risk of GI perforation. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Osteoporosis. Kaposi’s sarcoma. May cause electrolyte imbalances or psychotic manifestations. Avoid abrupt cessation. Monitor weight, growth, BP, IOP, fluid and electrolyte balance. Elderly. Pregnancy (Cat.D). Nursing mothers.

Interactions:

See Contraindications. Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbama-zepine, rifampin), cholestyramine, aminoglutethimide. May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Increased GI effects with aspirin or NSAIDs. Caution with aspirin in hypoprothrombinemia. Monitor for hypokalemia with potassium-depleting drugs. Withdraw anticholinesterase agents at least 24hrs before initiating therapy. May suppress reactions to skin tests.

See Also:

Prednisolone Oral Solution 15mg/5mL

Pharmacological Class:

Glucocorticoid.

Adverse Reactions:

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

How Supplied:

Soln (25mg/5mL)—8oz; 15mg/5mL—contact supplier

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