Pediatric Endocrinology Archive
Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.
Parents and healthcare workers should carefully consider the risk for obesity in infants born to women with diabetes, especially infants born large for gestational age, and should initiate preventive measures where possible.
Early treatment of cardiovascular disease risk factors such as dyslipidemia and hypertension will have long-term benefits with low risk and cost and should be more widely used in pediatric type 1 diabetes care.
Findings demonstrated a high incidence of sodium alterations in children following transsphenoidal surgery, with a 38% combined incidence of diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion.
Only approximately half of pediatric patients with a blood pressure reading ≥95th percentile would be correctly classified based on their initial blood pressure reading.
Children with T1D had statistically significantly higher prevalence rates of hypertension, hypercholesterolemia, and used more CV medication compared with a matched diabetes-free reference cohort in the period after the onset of diabetes.
Increased odds of fractures in pediatric patients with asthma may be associated with systemic corticosteroid use, but not with inhaled corticosteroid use.
Study investigated the correlations between age and body composition with trabecular morphology in a cohort of healthy girls age 9 to 18.
Study evaluated the safety and efficacy of autoantigen-specific therapy with alum-formulated glutamate decarboxylase in nondiabetic children with multiple islet autoantibodies.
More research is needed in order to better estimate hypoglycemic frequency in this population, determine the causes of these hypoglycemic episodes, and determine whether it is the sulfonylurea dose or outside factors that play a larger role.
Study sought to determine the optimal dosing of linagliptin for the treatment of children with type 2 diabetes.
Study sought to evaluate whether baseline autonomic dysfunction was predictive of future increases in urine albumin-creatinine ratio in pediatric patients with type 1 diabetes.
A study examined the efficacy and safety of predictive low-glucose management systems for the prevention of hypoglycemia in adolescents with type 1 diabetes.
An observational study was conducted by investigators to evaluate the progression of thyroid cancer in young individuals by ultrasonography.
Study underscores the need to focus on the peer context to understand the functioning of youths with type 1 diabetes.
Incentive-based approaches developed to improve daily adherence to a single behavioral process, such as blood glucose monitoring in adolescents, may not be as effective as multicomponent interventions that address emotional, social, and family processes of diabetes self-management.
More than half of today's children are expected to be obese at the age of 35 years, with about half of the prevalence occurring during childhood.
Islet and celiac disease autoimmunity were defined as a positive test result for islet or tissue transglutaminase autoantibodies at 2 clinic visits at least 3 months apart.
Investigators assessed the utilization of ATA risk stratification and TI-RADS ultrasound based systems for the assessment of pediatric thyroid nodules.
Among patients with childhood-onset type 1 diabetes, there is a very low incidence of end-stage renal disease.
A new study suggests that pancreatic exocrine dysfunction develops after initiation of islet cell autoimmunity, suggesting that exocrine dysfunction is related to diabetes disease pathogenesis itself.
There is a need for bridging the disconnect between policies that address underweight and overweight children and adolescents.
Higher-dose and specialized treatment content designed to help families maintain weight-control behaviors following family-based behavioral weight loss treatment enhances weight outcomes.
Study aimed to determine the effect of metformin on vascular health in children with T1D and above average weight.
Lower incidence of microalbuminuria was noted with the use of ACE inhibitors vs placebo.
Study finds for the first time that during pregnancy the associations between serum 25OHD concentration and 2 single nucleotide polymorphisms are stronger in mothers of children with T1D.
Researchers assessed the impact of maternal gestational diabetes on insulin resistance and adiposity in adolescent offspring.
Daily financial incentives improved glucose monitoring, but not glycemic control.
With a little communication, children with diabetes can still enjoy Halloween festivities.
While parathyroid hormone levels may be used to anticipate calcium decline, a "normal" PTH level does not always correctly predict postoperative calcium level.
Early thyroidectomy was preventative in a majority of pediatric patients with MEN2.
Previous trials suggested that vitamin D supplementation reduces rates of both influenza and other respiratory infections.
Although continuous glucose monitoring accuracy and safety in preterm infants has been validated in several studies, this approach has never been studied in neonates.
Rates of adrenal insufficiency and hypopituitarism were highest during infancy, particularly among females.
Gonadotropin-releasing hormone (GnRH) agonist Triptodur treats central precocious puberty via intramuscular injection.
Screening programs that measure T4 with reflex TSH in newborns with T4 below a specified cutoff have the potential to detect central congenital hypothyroidism (CCH) and have shown a higher prevalence of CCH than previously thought.
The American Academy of Pediatrics urges careful consideration between parents and clinicians prior to ordering these tests.
BMI measurement alone can also be used to determine associations between childhood and adulthood conditions.
The study included over 45,000 children using second-generation antipsychotic medications between 2009 and 2013.
Height gains "substantially outpaced" bone mineral content gains during childhood, potentially leading to increased fracture risk.
Revised ATA guidelines have led to an increased interest in risk-adopted management strategies for differentiated thyroid cancer.
Restricting consumption of high fructose corn syrup did not appear to improve insulin resistance in obese children.
Contraception conversations should take place as early as is appropriate.
Researchers assessed the relationship between serum vitamin D levels, number of patches, and disease severity and duration.
Patients with assumed monogenic diabetes were examined using a novel 3-part biomarker screening pathway to detect incorrectly diagnosed cases of type 1 diabetes.
Over 37,000 men were tracked from ages 8 to 20 to examine the link between adolescent BMI and stroke risk.
Data from a phase 3 clinical trial found that triptorelin achieved positive results in patients age 2 and older with central precocious puberty.
A Committee Opinion noted that mental health disorders may "interfere with adolescents' ability to understand or articulate" health concerns, including menstrual dysfunction and safe sexual behavior.
Metformin decreases BMI z score and improves inflammatory parameters in prepubertal children with obesity.
Updates to the US Preventive Services Task Force's recommendations on obesity screening in children and adolescents focus on intensive behavioral interventions.
Childhood obesity is linked to long-lasting mental health repercussions, including depression in adulthood.
A questionnaire was administered to participants who received preoperative information via either a web-based platform or conventional brochure.
Although increases in hemoglobin and hematocrit levels were recorded, findings support the safety of cross-sex hormones for transgender teens.
Early psychotic symptoms in child or adolescent patients were predictive of elevated BMI and waist circumference scores.
The evidence-based clinical practice guideline focuses on the prevention and treatment of childhood obesity.
Consumption of foods and beverages with low-calorie sweeteners such as aspartame, sucralose, and saccharin rose 200% among children between 1999 and 2012.
Treatment with growth hormone did not affect insulin sensitivity or insulin secretion in girls with Turner syndrome.
Best practices have been developed for managing children with celiac disease, according to a special article published online in Pediatrics.
Neonates born to mothers exposed to beta-blockers at the time of delivery have increased risk of neonatal hypoglycemia and bradycardia.
Student-athletes have similar rates of obesity and high blood pressure as non-athletes, according to research published in The Journal of Pediatrics.
When teenagers are overweight, parents and doctors should encourage a healthy lifestyle rather than focus on the number on the scale.
The US Preventive Services Task Force (USPSTF) has concluded that the evidence is currently insufficient to weigh the balance of benefits and harms of screening for lipid disorders in children and adolescents (aged 20 years or younger).
Physicians should be aware of the "female athlete triad," which includes amenorrhea, osteoporosis, and disordered eating.
The intervention combination can reduce preventable hypoglycemic events in hospitalized children receiving insulin.
Children who experienced acute arterial ischemic stroke were more likely to experience abnormal blood pressure, high blood glucose, and/or fever.
An infant presented with fatigue, irritability, and failure to gain weight after prolonged immobilization.
Ovarian cyst and McCune-Albright syndrome were most responsible for the increased risk of non-congenital adrenal hyperplasia gonadotropin-independent precocious puberty.
Determinants of care gaps included demographics, disease-related characteristics, health care service use, and patient health behaviors.
Higher body weight and taller stature during adolescence are associated with increased risk for non-Hodgkin lymphoma.
High maternal fish intake during pregnancy is associated with elevated risk for rapid growth in infancy, according to a study published in JAMA Pediatrics.
Mothers' vitamin B12 levels in early pregnancy may impact children's cardiometabolic risk factors at age 5 years.
Metabolic syndrome severity has decreased among adolescents from 1999 and 2012.
One in 50 boys are born with undescended testis, with two-thirds having no report of corrective surgery, researchers wrote in Pediatrics.
Standing desks in classrooms decreased children's sitting time by about 1 hour each day, according to a review published in Pediatrics.
A vaginal birth and breastfeeding make a notable difference in the bacterial composition of an infant's gut.
Children who develop certain signs of puberty at an early age are commonly referred to specialists for an evaluation, but this is often unnecessary.
American Academy of Pediatrics guidelines reflect concerns about obesity, suicide, and more.
Hyperandrogenic anovulation for more than 2 years distinguishes PCOS from physiologic anovulation, according to the review.
The researchers noted that more studies are needed to show cause-and-effect relationship.
Though calories remained same, obese children saw better BP, cholesterol, blood glucose levels
Teens with a later weekday bedtime more likely to experience increased BMI over time.
In larger doses, the diabetes drug may increase height in children and adolescents.
Walking breaks that interrupt sedentary behavior may help prevent obesity, diabetes.
Significant contributors include BMI z-score, age, pubertal stage, total sleep time and sleep efficiency.
Four out of 10 high school students with medical conditions used one or both in past year
However, evidence is to preliminary to recommend routine screening.
The first study in the United States to investigate the long-term outcomes of medical treatment for transgender youth is set to begin in the near future.
There was no difference in frequency of sex according to weight status among 18- to 19-year-old girls.
Long-term treatment with the histrelin implant safely and effectively sustained gonadotropin suppression and improved predicted adult height in central precocious puberty.
Ferring announced that the FDA has approved the name changes of its newly acquired products to be marketed as Zomacton (somatropin [rDNA origin]; formerly Tev-Tropin) for injection, and the needle-free delivery system as Zoma-Jet (formerly Tjet).
Animal research suggests that melatonin use in children with sleep disorders may affect the reproductive organs and endocrine system.
Significant improvements were seen in metabolic parameters, including BMI, cholesterol levels and insulin resistance.
Info about minutes or miles of activity required to burn off calories may be most helpful.
When pizza is consumed, it makes up more than 20% of children's daily intake of calories.
Researchers have discovered a single gene in a region of the X chromosome that may cause excessive growth in children.
Only half of college campus clinics feel they can handle diabetes care, and many don't reach out to students about needs.
Beloranib for treatment of Prader-Willi syndrome enters phase 3 trial.
New study doubles the number of gene regions linked to height.
Obese children in early primary school are significantly more likely to be involved with bullying, both as victim and perpetrator.
Overweight or obese children are now less likely to be perceived correctly by their parents vs. 10 years ago.
Endocrinology Advisor Articles
- Diabetic Retinopathy Risk Not Increased With GLP-1 Receptor Agonist Use in T2D
- Concurrent Risk Factors and Microvascular Complications in Type 1 Diabetes
- Higher Risk for Meningioma Linked to GH Treatment, Radiotherapy During Childhood
- Early Treatment Intensification and Faster Glycemic Control in T2D
- Executive Function Predicts T1D Management Into Emerging Adulthood
- Nutraceuticals May Benefit Patients Who Are Statin Intolerant
- Hypertension Treatments: ARBs
- Semaglutide vs Liraglutide for Weight Loss in Patients With Obesity
- Liraglutide May Lower Risk for Foot Amputation in Type 2 Diabetes
- Thyroid Hormone Levels, Body Composition, Insulin Resistance in Euthyroid Patients
- Cochrane Data Release and the Case for "Open Science"
- Rates of Incident Type 2 Diabetes in Chronic Kidney Disease
- Characteristics of Acquired Partial Lipodystrophy With Metabolic Abnormalities
- Poor Glycemic Control Associated With Higher Risk for Dementia in Older Adults With T1D
- Shift Seen From EDs to Urgent Care for Low-Acuity, Acute Care