Osteoporosis

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

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The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

Romosozumab Plus Alendronate Reduces Fracture Risk in Postmenopausal Osteoporosis

Romosozumab Plus Alendronate Reduces Fracture Risk in Postmenopausal Osteoporosis

Risk of new vertebral fracture was reduced among women int he romosozumab-to-alendronate group vs those who took alendronate alone.

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

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Researchers conducted a systematic review of available literature to create a guide for optimal management of patients with type 2 diabetes and osteoporosis.

FDA Requests Additional Data in Romosozumab Biologics License Application

FDA Requests Additional Data in Romosozumab Biologics License Application

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The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.

Does Sedative Use Increase Repeat Fall Risk?

Does Sedative Use Increase Repeat Fall Risk?

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Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.

ACP: Updated Osteoporosis Treatment Guidelines

ACP: Updated Osteoporosis Treatment Guidelines

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An update to the 2008 ACP osteoporosis treatment guidelines focuses on treating low bone density and osteoporosis in an effort to prevent fractures.

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Osteoporosis, Fracture Risk Elevated With Tuberculosis

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Tuberculosis was identified as an independent risk factor associated with incident osteoporosis.

Osteoporosis Treatment Approaches in Women vs Men

Osteoporosis Treatment Approaches in Women vs Men

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A review of osteoporosis diagnosis, treatment, and management in both men and women.

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Eighty-four percent of survey respondents did not undergo osteoporosis pharmacotherapy following an osteoporosis-related fracture.

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

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Tymlos approval was based on the results of the ACTIVE and ACTIVExtension trials.

HIV-Induced Osteoporosis Detected Using Bone Ultrasonography

HIV-Induced Osteoporosis Detected Using Bone Ultrasonography

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Bone ultrasonography is able to detect tenofovir-induced bone loss in patients with HIV.

Denosumab-induced Prolonged Hypocalcemia: A Case Study

Denosumab-induced Prolonged Hypocalcemia: A Case Study

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Investigators examined an 83-year-old male patient who developed severe hypocalcemia induced by denosumab.

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

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The most common adverse events associated with long-term denosumab use were back, musculoskeletal, or extremity pain, hypercholesterolemia, and cystis.

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

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The most important predictor for use of osteoporosis care was receiving primary care services within 6 months following hip fracture.

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

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Neither DXA-visceral adipose tissue nor android-gynoid fat mass ratios were associated with atherosclerotic cardiovascular disease events.

Leg Positioning During Lumbar Spine DXA

Leg Positioning During Lumbar Spine DXA

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Researchers evaluated trabecular bone scores in more than 100 women during either "legs up" or "legs down" dual energy x-ray absorptiometry scans.

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

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Using dual-energy X-ray absorptiometry for bone age assessment complements traditional radiologic assessment.

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

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Fragility fracture risk increased with older age and decreased with higher bone mineral density in patients with type 1 diabetes.

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

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Researchers compared the efficacy of dual-energy x-ray absorptiometry with lateral x-ray in assessing vertebral fractures.

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

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The Bone Health TeleECHO Clinic helps telementor healthcare professionals and improves osteoporosis care in underserved communities.

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

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Testosterone treatment improved both bone mineral density and strength in older men.

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

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Researchers found that female patients recovering from critical illness respond better to anti-fracture therapy for bone mineral density loss prevention compared with men.

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

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Study examines the predictive value for vertebral fractures of bone mineral density and bone turnover markers after a 5-year drug holiday.

Bisphosphonate Drug Holiday Increases Fracture Risk in Postmenopausal Women

Bisphosphonate Drug Holiday Increases Fracture Risk in Postmenopausal Women

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The risk of developing fracture in postmenopausal women with osteoporosis who discontinued bisphosphonate therapy was evaluated in a retrospective study.

Nonvertebral Fracture Risk After Roux-en-Y Gastric Bypass

Nonvertebral Fracture Risk After Roux-en-Y Gastric Bypass

Researchers examined the nonvertebral fracture risk in adults with obesity who underwent Roux-en-Y gastric bypass vs adjustable gastric banding.

Older Men With Low Total, Bioavailable Testosterone at Increased Risk for Falls

Older Men With Low Total, Bioavailable Testosterone at Increased Risk for Falls

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Incident falls were linked with total testosterone and bioavailable levels of testosterone after adjusting for age and prevalent falls.

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Two distinct time trends were observed in initiation of oral bisphosphonates in women after the 2008 updated osteoporosis treatment guidelines.

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