Osteoporosis Archive

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Researchers have determined that treatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid.

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Researchers investigated the effects of growth hormone vs placebo, as well as the effects of sex steroid replacement therapy on bone mineral density in growth hormone-treated young adults with Prader-Willi syndrome who had attained adult height.

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Researchers showed that decreased L1 trabecular attenuation is associated with increased risk for future osteoporotic fractures in adult patients aged ≥65 years undergoing abdominopelvic CT scans for other indications.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

FDA Requests Additional Data in Romosozumab Biologics License Application

FDA Requests Additional Data in Romosozumab Biologics License Application

The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.

Does Sedative Use Increase Repeat Fall Risk?

Does Sedative Use Increase Repeat Fall Risk?

Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.

ACP: Updated Osteoporosis Treatment Guidelines

ACP: Updated Osteoporosis Treatment Guidelines

An update to the 2008 ACP osteoporosis treatment guidelines focuses on treating low bone density and osteoporosis in an effort to prevent fractures.

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Tuberculosis was identified as an independent risk factor associated with incident osteoporosis.

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Eighty-four percent of survey respondents did not undergo osteoporosis pharmacotherapy following an osteoporosis-related fracture.

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

Tymlos approval was based on the results of the ACTIVE and ACTIVExtension trials.

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

The most common adverse events associated with long-term denosumab use were back, musculoskeletal, or extremity pain, hypercholesterolemia, and cystis.

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

The most important predictor for use of osteoporosis care was receiving primary care services within 6 months following hip fracture.

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

Researchers compared the efficacy of dual-energy x-ray absorptiometry with lateral x-ray in assessing vertebral fractures.

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

Fragility fracture risk increased with older age and decreased with higher bone mineral density in patients with type 1 diabetes.

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

Using dual-energy X-ray absorptiometry for bone age assessment complements traditional radiologic assessment.

Leg Positioning During Lumbar Spine DXA

Leg Positioning During Lumbar Spine DXA

Researchers evaluated trabecular bone scores in more than 100 women during either "legs up" or "legs down" dual energy x-ray absorptiometry scans.

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

Neither DXA-visceral adipose tissue nor android-gynoid fat mass ratios were associated with atherosclerotic cardiovascular disease events.

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

The Bone Health TeleECHO Clinic helps telementor healthcare professionals and improves osteoporosis care in underserved communities.

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

Testosterone treatment improved both bone mineral density and strength in older men.

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

Researchers found that female patients recovering from critical illness respond better to anti-fracture therapy for bone mineral density loss prevention compared with men.

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

Study examines the predictive value for vertebral fractures of bone mineral density and bone turnover markers after a 5-year drug holiday.

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Two distinct time trends were observed in initiation of oral bisphosphonates in women after the 2008 updated osteoporosis treatment guidelines.

Fracture Risk in Psoriatic Arthritis, Psoriasis Examined

Fracture Risk in Psoriatic Arthritis, Psoriasis Examined

Patients with psoriatic arthritis or psoriasis had an increased prevalence of osteoporosis risk factors.

FDA Clears Point-of-Care Device for Diagnosing Osteoporosis

FDA Clears Point-of-Care Device for Diagnosing Osteoporosis

Bone Index announced that the Food and Drug Administration (FDA) has granted clearance for the second generation Bindex device model to aid in the diagnosis of osteoporosis.

Bone Density Linked to Vascular Calcification in ESRD

Bone Density Linked to Vascular Calcification in ESRD

A prospective cohort study in 66 patients with end-stage renal disease was conducted to determine the link between renal and coronary heart diseases.

Long-Term DPP-4 Inhibitor Use Not Associated With Fracture Risk in Type 2 Diabetes

Long-Term DPP-4 Inhibitor Use Not Associated With Fracture Risk in Type 2 Diabetes

For patients with type 2 diabetes, long-term use of dipeptidyl peptidase-4 (DPP-4) inhibitors is not associated with fracture risk.

VIDEO: Clinical Trial Results for Abaloparatide

Lorraine Fitzpatrick, MD, discusses updated results from the ACTIVE phase 3 clinical trial.

Does Antihypertensive Medication Class Affect Fracture Risk?

Does Antihypertensive Medication Class Affect Fracture Risk?

Researchers compared 3 classes of antihypertensive medication to determine hip and pelvic fracture risk in users vs nonusers.

New Osteoporosis Treatment Options on the Horizon

Nancy E. Lane, MD, professor of medicine, at the University of California at Davis School of Medicine, discusses results from the phase 3 ACTIVE trial.

Bone Density Lower Among Heavy Cannabis Users

Bone Density Lower Among Heavy Cannabis Users

Heavy cannabis users have lower bone density compared to cigarette smokers.

Bone Mineral Density Linked to Concentrations of 25(OH)D in Summer

Bone Mineral Density Linked to Concentrations of 25(OH)D in Summer

Summer levels of serum 25-hydroxyvitamin D are associated with bone mineral density of the total hip.

AACE/ACE Updates Postmenopausal Osteoporosis Management Guidelines

AACE/ACE Updates Postmenopausal Osteoporosis Management Guidelines

The American Association of Clinical Endocrinologists (AACE) and the American College of Endocrinology (ACE) announced the publication of new clinical guidelines and an accompanying algorithm to help physicians and other health care professionals with the diagnosis, fracture risk assessment, and treatment of postmenopausal osteoporosis.

Fracture Risk in Diabetes No Higher With Sitagliptin

Fracture Risk in Diabetes No Higher With Sitagliptin

According to results from the TECOS trial, sitagliptin is not linked to an increased risk for fractures in patients with diabetes.

Fracture Risk Lower With Abaloparatide in Osteoporosis

Fracture Risk Lower With Abaloparatide in Osteoporosis

In postmenopausal women with osteoporosis, an experimental drug appears to reduce the risk of bone fractures better than teriparatide or a placebo.

New Index Predicts Women at Risk for Rapid Bone Loss During Menopausal Transition

New Index Predicts Women at Risk for Rapid Bone Loss During Menopausal Transition

An index accounting for both bone formation and resorption may help identify which women may experience faster bone loss during menopause.

Treatment-Related Changes in Bone Density Linked to Fracture Risk in Osteoporosis

Treatment-Related Changes in Bone Density Linked to Fracture Risk in Osteoporosis

For women initiating osteoporosis treatment, treatment-related changes in total hip bone mineral density (BMD) are associated with fracture risk.

Hormone Replacement Therapy vs Combination Oral Contraceptive for Bone Health in Premature Ovarian Failure

Hormone Replacement Therapy vs Combination Oral Contraceptive for Bone Health in Premature Ovarian Failure

In women with premature ovarian failure, hormone replacement therapy was associated with greater increases in bone mineral density.

Proton Pump Inhibitor Use Increases Risk of Osteoporosis and Osteopenia in Femur

Proton Pump Inhibitor Use Increases Risk of Osteoporosis and Osteopenia in Femur

Proton pump inhibitor users had reduced mean femoral T-scores and increased frequency of osteoporosis and osteopenia.

Pop-Up Messages May Be Beneficial for Physician Awareness of Osteoporosis

Pop-Up Messages May Be Beneficial for Physician Awareness of Osteoporosis

Messages were linked to increased rates of DXA prescription and osteoporosis medication.

Parental Hip Fracture Linked to Increased Fracture Risk in Offspring

Parental Hip Fracture Linked to Increased Fracture Risk in Offspring

The strength of the correlation decreases with older parental age at hip fracture.

Drop in Bisphosphonate Use Noted After FDA Safety Announcement

Drop in Bisphosphonate Use Noted After FDA Safety Announcement

Researchers observed a 4% decrease in odds of bisphosphonate use each quarter after safety announcement for atrial fibrillation risk.

Case Report: Bisphosphonate-Related Osteonecrosis of the Jaw in Diabetes

Case Report: Bisphosphonate-Related Osteonecrosis of the Jaw in Diabetes

Case report describes osteonecrosis of the jaw in 80-year-old woman with diabetes.

Oral Bisphosphonates Lowered Mortality, Subsequent Fracture Risks

Oral Bisphosphonates Lowered Mortality, Subsequent Fracture Risks

Oral bisphosphonates appear to lower the risk for subsequent fracture and mortality after fracture.

Study Identifies Barriers to Osteoporosis Prevention

Study Identifies Barriers to Osteoporosis Prevention

Many older people unconcerned about or unaware of osteoporosis.

Race May Affect Atypical Femur Fracture Risk in Women Taking Bisphosphonates

Race May Affect Atypical Femur Fracture Risk in Women Taking Bisphosphonates

Asian women taking bisphosphonates may have a higher risk for atypical femur fracture than white women.

Bisphosphonates May Improve Bone Balance in Postmenopausal Women

Bisphosphonates May Improve Bone Balance in Postmenopausal Women

Treatment improved bone balance and reduced bone turnover.

Romosozumab Boosted Bone Strength in Postmenopausal Women

Romosozumab Boosted Bone Strength in Postmenopausal Women

The sclerostin inhibitor may increase bone strength at the spine and hip in postmenopausal women.

Denosumab for 10 Years Is Safe, Effective in Older Women

Denosumab for 10 Years Is Safe, Effective in Older Women

Denosumab treatment for up to 10 years is linked to persistent reduction in bone turnover and increased BMD.

Drinking Tea May Help Lower Fracture Risk

Drinking Tea May Help Lower Fracture Risk

Three or more cups per day may lower risk for fracture.

Abaloparatide Reduced Fracture Incidence in Postmenopausal Women

Abaloparatide Reduced Fracture Incidence in Postmenopausal Women

Fracture risk may be significantly lower in postmenopausal women with abaloparatide vs. teriparatide or placebo.

Trabecular Bone Score, HbA1c May Predict Fractures in Type 1 Diabetes

Trabecular Bone Score, HbA1c May Predict Fractures in Type 1 Diabetes

While these may serve as predictors, bone mineral density may not.

Calcium Intake May Not Affect Fracture Risk

Calcium Intake May Not Affect Fracture Risk

Researchers find no evidence that increasing intake will prevent fractures.

Growth Hormone May Boost Bone Health in Older Women

Growth Hormone May Boost Bone Health in Older Women

However, researcher says high cost, need to get shots in clinics make it an unlikely osteoporosis treatment.

'My Osteoporosis Went Away But My Diabetes Got Worse...'

'My Osteoporosis Went Away But My Diabetes Got Worse...'

An older women with type 2 diabetes and osteoporosis experienced improvements with one condition at the expense of the other.

Lumbar Spine Bone Density Contributes to Fracture Risk in Some Women

Lumbar Spine Bone Density Contributes to Fracture Risk in Some Women

A lower T-score for lumbar spine than femoral neck increases fracture risk, particularly in older women.

Osteoporosis Prevalence Examined in Older Adults

Osteoporosis Prevalence Examined in Older Adults

Prevalence of osteoporosis 16.2% in adults aged 65 years and older, while prevalence of low bone mass is 48.3%.

Bone Density, Muscle Mass Not Improved With High-Dose Vitamin D in Women

Bone Density, Muscle Mass Not Improved With High-Dose Vitamin D in Women

No increases were seen in bone density, muscle mass or mobility in postmenopausal women.

Specific Exercises Improved Bone Health in Men

Specific Exercises Improved Bone Health in Men

Resistance and jump training benefit middle-aged men.

Kidney, Bladder Stones Not Linked to Osteoporosis Risk in Women

Kidney, Bladder Stones Not Linked to Osteoporosis Risk in Women

The presence of urinary tract stones raises the risk for osteoporosis in men but not women.

Some Women May Need Less Frequent Bone Density Testing

Some Women May Need Less Frequent Bone Density Testing

Fracture risk is very low for younger postmenopausal women with no osteoporosis.

DXA Screening Overused in Some, Underused in Others

DXA Screening Overused in Some, Underused in Others

Researchers find patients at highest risk for fractures often miss out on tests, while those at low risk are being screened.

Effects of Cyclic vs. Daily Teriparatide on BMD in Osteoporosis

Effects of Cyclic vs. Daily Teriparatide on BMD in Osteoporosis

Cyclic treatment with teriparatide yields improvements in bone mineral density that are similar to daily treatment in women taking alendronate.

Osteoporosis Linked to Increased Risk for Sudden Hearing Loss

Osteoporosis Linked to Increased Risk for Sudden Hearing Loss

People with osteoporosis are nearly twice as likely to develop sudden deafness as those without the condition.

Muscle Mass Associated With Bone Development in Children

Muscle Mass Associated With Bone Development in Children

Higher muscle mass appears to be strongly associated with healthier bone development in young children.

Zoledronic Acid Improved Bone Density in Frail Elderly Women

Zoledronic Acid Improved Bone Density in Frail Elderly Women

A single IV dose of zoledronic acid improved bone mineral density in frail elderly women living in nursing homes and long-term care facilities.

Osteoporosis-Related Fractures, Costs to Double by 2035 in China

Osteoporosis-Related Fractures, Costs to Double by 2035 in China

Projections indicate that the incidence and costs of fractures related to osteoporosis will double by 2035 in China, according to new data.

Endometrial Cancer Risk Reduced With Oral Bisphosphonate Use

Endometrial Cancer Risk Reduced With Oral Bisphosphonate Use

Ever use of bisphosphonates associated with modest decrease in risk in cohort of nearly 90,000 postmenopausal women.

Fracture Risk May Predict Risk for Gum Disease in Women

Fracture Risk May Predict Risk for Gum Disease in Women

Women at high risk for fracture may have an increased risk for gum disease as well.

Mortality Risk Elevated in Adults Treated for Osteoporosis

Mortality Risk Elevated in Adults Treated for Osteoporosis

Residual life expectancy for 50- and 75-year-old man starting treatment estimated at 18.2 and 7.5 years.

Weight Changes Linked to More Fractures in Older Women

Weight Changes Linked to More Fractures in Older Women

In postmenopausal women, both weight gain and weight loss are associated with an increased incidence for fracture.

Denosumab Increased Treatment Satisfaction in Postmenopausal Women

Denosumab Increased Treatment Satisfaction in Postmenopausal Women

Postmenopausal women reported greater treatment satisfaction when switched from a once-monthly oral bisphosphonate to denosumab.

Bisphosphonate Prescriptions Low Among Men on Androgen Deprivation Therapy

Bisphosphonate Prescriptions Low Among Men on Androgen Deprivation Therapy

Despite recommendations, prescriptions for bisphosphonates remain low among men on androgen deprivation therapy.

Rosuvastatin Failed to Decrease Fracture Risk

Rosuvastatin Failed to Decrease Fracture Risk

Statin therapy with rosuvastatin did not reduce the risk for fracture among patients with high-sensitivity C-reactive protein levels.

Men Less Likely to Be Screened for Osteoporosis After Fracture

Men Less Likely to Be Screened for Osteoporosis After Fracture

Older men are less likely to be screened for osteoporosis or receive treatment after wrist fractures.

Milk Intake Linked to Mortality, Fracture Risks in Women

Milk Intake Linked to Mortality, Fracture Risks in Women

Men and women who drank more milk may have increased mortality risk, while women may also have an increased risk for fractures.

BMI May Predict Osteoporosis in Younger Postmenopausal Women

BMI May Predict Osteoporosis in Younger Postmenopausal Women

A BMI of 28 may serve as a better predictor of osteoporosis than other screening methods in younger postmenopausal women.

Could Red Wine Compound Treat Osteoporosis?

Could Red Wine Compound Treat Osteoporosis?

Resveratrol was linked to increases in spinal bone density in men with metabolic syndrome.

Minivelle Approved for Postmenopausal Osteoporosis Prevention

Minivelle Approved for Postmenopausal Osteoporosis Prevention

The FDA has approved a new indication with a new dose of Minivelle (estradiol transdermal system) for prevention of postmenopausal osteoporosis.

Higher Vitamin D Levels During Menopause May Reduce Fracture Risk

Higher Vitamin D Levels During Menopause May Reduce Fracture Risk

Women with higher vitamin D levels during midlife may have a lower risk for fractures.

Combination Denosumab, Teriparatide Beneficial for Bone Density

Combination Denosumab, Teriparatide Beneficial for Bone Density

Denosumab plus teriparatide increased bone density effected greater increases in bone density than either drug alone in women with osteoporosis.

Denosumab Repaired Cortical Bone Loss in Osteoporosis

Denosumab Repaired Cortical Bone Loss in Osteoporosis

Women with osteoporosis experienced increase in bone density and lower wrist fracture rates after treatment with denosumab.

Bisphosphonate 'Drug Holidays' Don't Raise Fracture Risk in Women With Osteoporosis

Bisphosphonate 'Drug Holidays' Don't Raise Fracture Risk in Women With Osteoporosis

Taking a break from bisphosphonates did not appear to be harmful in women with osteoporosis.

Zoledronic Acid Safe, Effective for 3 Years in Frail Women With Osteoporosis

Zoledronic Acid Safe, Effective for 3 Years in Frail Women With Osteoporosis

Zoledronic acid improved bone mass in frail, older women with osteoporosis for 3 years.

Risk Factor Index Predicts Fracture in Elderly

Risk Factor Index Predicts Fracture in Elderly

The Downton Fall Risk Index predicts fall-related hip fracture and other osteoporotic fractures in older men and women.

Osteoporosis Drugs Reduce Fracture Risk, But Comparative Data Are Lacking

Osteoporosis Drugs Reduce Fracture Risk, But Comparative Data Are Lacking

Good-quality evidence supports the efficacy of several medications for osteoporosis, but the comparative effectiveness of these drugs is unclear.

Bisphosphonate Use Tied to Increased Atypical Femoral Fracture Risk

Bisphosphonate Use Tied to Increased Atypical Femoral Fracture Risk

Bisphosphonate use, especially over a long duration, is associated with increased risk for atypical femoral fracture.

Osteoporosis Drug Raloxifene Has Novel Mode of Action

Osteoporosis Drug Raloxifene Has Novel Mode of Action

Raloxifene has a novel mechanism of action that may lead to a new class of drugs to treat osteoporosis.

Primary Hyperparathyroidism Screening Needs Improvement

Primary Hyperparathyroidism Screening Needs Improvement

More patients with abnormal bone mineral density should undergo screening for primary hyperparathyroidism.

Marriage Related to Bone Health in Men and Women

Marriage Related to Bone Health in Men and Women

Marital disruption impairs bone health in men; marital support linked to high BMD in women.

Low Bone Mineral Density: A Global Health Burden?

Low Bone Mineral Density: A Global Health Burden?

Low bone mineral density represents a growing health problem across the world.

Identifying Men Who Benefit from Drug Treatment for Fracture Prevention

Identifying Men Who Benefit from Drug Treatment for Fracture Prevention

WHO criteria better than National Osteoporosis Foundation criteria for identifying men who would benefit from drug treatment.

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