Benefits of Sustained Weight Loss in Type 2 Diabetes

Researchers found reduced levels of HbA1c, triglycerides, LDL-cholesterol, and quality of life in patients who reported sustained weight loss.
Researchers found reduced levels of HbA1c, triglycerides, LDL-cholesterol, and quality of life in patients who reported sustained weight loss.

HealthDay News — For overweight, but not obese, individuals with type 2 diabetes, sustained weight loss of 10% body weight is associated with clinically meaningful cardiometabolic changes, according to research published online in Diabetes Care.

John M. Wentworth, MBBS, PhD., from Monash University in Clayton, Australia, and colleagues reported 5-year outcomes of a randomized trial of laparoscopic adjustable gastric band surgery in overweight, but not obese, Australians with type 2 diabetes of less than 5 years' duration. Twenty-two participants were randomized to gastric band surgery combined with medical care and 23 to medical care alone.

The researchers found that over 5 years of the study, the average weight loss was 12.2% and 1.8% percent in gastric band surgery and medical care participants, respectively. Diabetes remission was seen in 23% and 9% percent of gastric band surgery and medical care participants, respectively, at 5 years. Gastric band participants used fewer glucose-lowering medications and they had 10.4 mmol/mol lower HbA1c than medical care participants over 5 years of follow-up. In the context of less frequent use of lipid-lowering drugs, the mean high-density lipoprotein cholesterol was 0.24 mmol/L higher and triglycerides 0.7 mmol/L lower in gastric band participants, while low-density lipoprotein cholesterol was 0.5 mmol/L higher. Quality of life and health utility showed early and sustained improvement in the gastric band group.

"Sustained weight loss of 10% body weight is a powerful therapy for overweight but not obese people with type 2 diabetes," the authors write.

A grant from Allergan was received by the Center for Obesity Research and Education at Monash University, which funded the study. Allergan also donated the lap-band prostheses used in the study.

Reference

Wentworth JM, Burthon P, Laurie C, Brown WA, O'Brien PE. Five-year outcomes of a randomized trial of gastric band surgery in overweight but not obese people with type 2 diabetes [published online February 19]. Diabetes Care. doi: 10.2337/dc16=2149

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