Adiposity Affected by Interaction of Certain Genotypes and Diet

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Certain genotypes may interact with dietary intake, thereby affecting central adiposity and body fat composition.
Certain genotypes may interact with dietary intake, thereby affecting central adiposity and body fat composition.

HealthDay News -- Fibroblast growth factor 21 (FGF21) genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition, according to a study published in Diabetes Care.

Yoriko Heianza, from Tulane University in New Orleans, and colleagues genotyped FGF21 rs838147 in 715 overweight or obese individuals who were assigned to 1 of 4 diets with varied macronutrient contents.

The researchers observed a significant interaction between FGF21 genotype and carbohydrate/fat intake on 2-year changes in waist circumference (P=.049), as well as percentage of fat mass and trunk fat (P=.001 and .003, respectively). 

Carrying the carbohydrate intake-decreasing C allele of rs838147 was marginally associated with less reduction in waist circumference in response to the low-carbohydrate/high-fat diet (P=.08), and was significantly associated with less reduction of total fat mass and trunk fat (P=.01 and .02, respectively). 

Among the high-carbohydrate/low-fat diet group, opposite genetic associations with these outcomes were observed; carrying the C allele correlated with a greater reduction in waist circumference, total body fat mass, and trunk fat.

"A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity," the researchers wrote.

Reference

  1. Heianza Y, Ma W, Huang T, et al. Macronutrient intake–associated FGF21 genotype modifies effects of weight-loss diets on 2-year changes of central adiposity and body composition: The POUNDS Lost trial. Diabetes Care. 2016. doi:10.2337/dc16-1111.
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