Gastric Bypass Reduces Symptoms, Hormonal Responses to Hypoglycemia

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Gastric bypass was linked to reduced symptoms and neurohormonal responses to hypoglycemia.
Gastric bypass was linked to reduced symptoms and neurohormonal responses to hypoglycemia.

(HealthDay News) — Gastric bypass surgery is associated with reduced symptoms and neurohormonal responses to hypoglycemia, according to a study published in Diabetes.

Noting that gastric bypass surgery patients have lowered glucose levels and frequent asymptomatic hypoglycemic episodes, Niclas Abrahamsson, MD, PhD, from Uppsala University in Sweden, and colleagues examined symptoms and hormonal and autonomic nerve responses in patients exposed to hypoglycemia before and after gastric bypass. Twelve obese patients without diabetes underwent hyperinsulinemic hypoglycemic clamp before and after gastric bypass surgery.

The researchers found that after surgery the Edinburgh Hypoglycemia symptom delta scores during clamp were attenuated from 10.7 to 5.2. Marked reductions in glucagon, cortisol, catecholamine, and sympathetic nerve responses to hypoglycemia were seen after surgery. A delayed response was seen in growth hormones, but to a higher peak level. During hypoglycemia, glucagon-like peptide-1 and gastric inhibitory peptide increased, but to a lesser extent after surgery.

"Gastric bypass surgery causes a resetting of glucose homeostasis, which reduces symptoms and neurohormonal responses to hypoglycemia," the researchers wrote. "Further studies should address the underlying mechanisms as well as their impact on the overall metabolic effects of gastric bypass surgery."

Disclosure: The study was partially funded by Exodiab.


  1. Abrahamsson N, Börjesson JL, Sundbom M, Wiklund U, Karlsson FA, Eriksson JW. Gastric bypass reduces symptoms and hormonal responses in hypoglycemia. Diabetes. 2016. doi:10.2337/db16-0341.
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