Insulin Sensitivity Improved Rapidly After Bariatric Surgery

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Bariatric surgery appeared to improve insulin sensitivity in patients without diabetes.
Bariatric surgery appeared to improve insulin sensitivity in patients without diabetes.

HealthDay News -- For obese patients without diabetes, bariatric surgery improves insulin sensitivity, with more pronounced improvements for Roux-en-Y gastric bypass (RYGB) than for laparoscopic adjustable gastric banding (LAGB), according to a study published online in Diabetes Care.

Amalia Gastaldelli, PhD, from the CNR Institute of Clinical Physiology in Pisa, Italy, and colleagues compared the short-term effects of bariatric surgical procedures with a very low caloric intake on insulin sensitivity and insulin secretion. Twenty obese patients without diabetes were admitted for 1 week of very low caloric intake; about 3 months later, 10 patients underwent LAGB and 10 underwent RYGB. One week after surgery, the participants were restudied under the same very low caloric intake regimen.

The researchers found that patients lost 2.1 kg after 1 week of very low caloric intake, with no significant changes in hepatic insulin sensitivity, adipose insulin sensitivity, peripheral insulin sensitivity, or disposition index. Greater weight loss was seen with RYGB (5.5 kg) and LAGB (5.2 kg), which also correlated with significant improvement in hepatic insulin sensitivity, endogenous glucose production, and lipolysis. RYGB improved adipose insulin sensitivity and peripheral insulin sensitivity. There was no change in insulin secretion or disposition index in either surgical group.

"Bariatric surgery improves insulin sensitivity within 1 week," the researchers wrote. "These metabolic effects were independent of caloric intake and more pronounced after RYGB compared with LAGB."

Disclosures: The study was funded by F. Hoffmann-La Roche.


  1. Gastaldelli A, Iaconelli A, Gaggini M, et al. Short-term effects of laparoscopic adjustable gastric banding versus Roux-en-Y gastric bypass. Diabetes Care. 2016. doi:10.2337/dc15-2823.
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