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NIPRIDE RTU
Bleeding disorders
CHF and arrhythmias
Hypertension
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Drug Name:

NIPRIDE RTU Rx

Generic Name and Formulations:
Sodium nitroprusside 0.5mg/mL (in 0.9% sodium chloride); soln for IV infusion; preservative-free.

Company:
Exela Pharma Sciences

Therapeutic Use:

Indications for NIPRIDE RTU:

Induction and maintenance of controlled hypotension to reduce surgical bleeding.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min. Renal impairment (eGFR <30mL/min/1.73m2): limit to <3microgram/kg/min. Anuric: limit to 1microgram/kg/min.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute HF associated with reduced peripheral vascular resistance. Concomitant sildenafil, tadalafil, vardenafil, or riociguat.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); discontinue if develops; treat appropriately. Monitor plasma thiocyanate levels if cumulative dose >7mg/kg/day. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Interactions:

See Contraindications. Hypotensive effect potentiated by ganglionic blocking agents and inhaled anesthetics.

Pharmacological Class:

Vasodilator.

Adverse Reactions:

Excessive hypotension, cyanide/thiocyanate toxicity, methemoglobinemia, anemia, hypovolemia.

Generic Availability:

NO

How Supplied:

Single-dose vials (100mL)—1

Indications for NIPRIDE RTU:

Acute HF.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min. Renal impairment (eGFR <30mL/min/1.73m2): limit to <3microgram/kg/min. Anuric: limit to 1microgram/kg/min.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute HF associated with reduced peripheral vascular resistance. Concomitant sildenafil, tadalafil, vardenafil, or riociguat.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); discontinue if develops; treat appropriately. Monitor plasma thiocyanate levels if cumulative dose >7mg/kg/day. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Interactions:

See Contraindications. Hypotensive effect potentiated by ganglionic blocking agents and inhaled anesthetics.

Pharmacological Class:

Vasodilator.

Adverse Reactions:

Excessive hypotension, cyanide/thiocyanate toxicity, methemoglobinemia, anemia, hypovolemia.

Generic Availability:

NO

How Supplied:

Single-dose vials (100mL)—1

Indications for NIPRIDE RTU:

Immediate reduction of blood pressure during hypertensive crises.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min. Renal impairment (eGFR <30mL/min/1.73m2): limit to <3microgram/kg/min. Anuric: limit to 1microgram/kg/min.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute HF associated with reduced peripheral vascular resistance. Concomitant sildenafil, tadalafil, vardenafil, or riociguat.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); discontinue if develops; treat appropriately. Monitor plasma thiocyanate levels if cumulative dose >7mg/kg/day. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Interactions:

See Contraindications. Hypotensive effect potentiated by ganglionic blocking agents and inhaled anesthetics.

Pharmacological Class:

Vasodilator.

Adverse Reactions:

Excessive hypotension, cyanide/thiocyanate toxicity, methemoglobinemia, anemia, hypovolemia.

Generic Availability:

NO

How Supplied:

Single-dose vials (100mL)—1

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