Generic Name and Formulations:
Acetohydroxamic acid 250mg; tabs.
Mission Pharmacal Company
Indications for LITHOSTAT:
As adjunctive therapy in chronic urea-splitting urinary infection.
Initially 12mg/kg per day every 6–8hrs; max 1.5g/day. Renal impairment: serum creatinine >1.8mg/dL: take at every 12-hour intervals; max 1g/day.
Initially 10mg/kg per day; monitor. Titrate doses to obtain therapeutic effects.
Disease and physical state amenable to surgery and antimicrobials. Urine infected by non-urease producing organisms. Infections controllable by oral antimicrobials. Renal dysfunction (CrCl <20mL/min, serum creatinine >2.5mg/dL). Females with unsatisfactory method of contraception. Pregnancy (Cat.X).
Severe renal impairment: monitor and consider reduced dose. Monitor liver function. Preexisting thrombophlebitis or phlebothrombosis. Monitor and obtain CBCs with reticulocytes after 2 weeks of therapy and every 3 months thereafter; if reticulocytes >6%, consider reduced dose. Nursing mothers: not recommended.
Rash with concomitant alcohol. Concomitant dietary iron: may reduce absorption of both acetohydroxamic acid and iron (use IM inj form, if needed).
Mild headaches, tremulousness, nervousness, depression, anxiety, GI upset, hemolytic anemia, mild reticulocytosis without anemia, rash, alopecia, phlebitis, palpitations.
Endocrinology Advisor Articles
- Behavioral Weight Loss Interventions May Prevent Obesity
- Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D
- Executive Function Predicts T1D Management Into Emerging Adulthood
- Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes
- Rates of Incident Type 2 Diabetes in Chronic Kidney Disease
- Bioethics Concerns Should Be a Key Element in mHealth Technology Development
- Gestational Diabetes Associated With Increased Risk for Postpartum Depression
- High Prevalence of Obstructive Sleep Apnea Syndrome May Favor Screening in Diabetes
- Update on the T2D-Dementia Link: Interview With Experts
- Dozens of Medical Groups Join Forces to Improve Diagnoses