Lipids/Cholesterol

Metabolic Concerns With Dutasteride Therapy for BPH

Metabolic Concerns With Dutasteride Therapy for BPH

Dutasteride therapy for benign prostatic hyperlasia has been linked to elevated HbA1c and LDL cholesterol.

Statin Intolerance Contributes to Higher Risk for MI and CHD

Statin Intolerance Contributes to Higher Risk for MI and CHD

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Patients with statin intolerance had a 36% higher rate of recurrent MI compared to those with high statin adherence.

Effects of Sex-Dependent On-Treatment LDL Diferences on CVD Risk

Effects of Sex-Dependent On-Treatment LDL Diferences on CVD Risk

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Women experienced the same CV benefits in statin trials, despite having slightly elevated on-treatment LDL cholesterol.

Incident CHD Risk Elevated With High Triglycerides, Low HDL

Incident CHD Risk Elevated With High Triglycerides, Low HDL

Risk of both ischemic stroke and coronary heart disease was elevated with high triglycerides and low high-density lipoprotein cholesterol.

Are Extremely Low LDL Cholesterol Levels Safe?

Are Extremely Low LDL Cholesterol Levels Safe?

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Low levels of low-density lipoprotein cholesterol appear to be well tolerated on alirocumab therapy.

Too Few Young Adults Are Prescribed Needed Statins

Too Few Young Adults Are Prescribed Needed Statins

Too few American young adults are receiving needed statin medications, according to findings published in JAMA Cardiology.

Fenofibrate Therapy Beneficial in Diabetes With Dyslipidemia

Fenofibrate Therapy Beneficial in Diabetes With Dyslipidemia

Fenofibrate therapy may reduce cardiovascular disease (CVD) in statin-treated patients with diabetes and dyslipidemia.

Oxidative Stress Associated With Metabolic Syndrome

Oxidative Stress Associated With Metabolic Syndrome

Oxidized low-density lipoprotein (ox-LDL) as a proxy for oxidative stress is associated with metabolic syndrome and its components.

Total, LDL Cholesterol Levels Decreasing in the United States

Total, LDL Cholesterol Levels Decreasing in the United States

Healthier diets may be a factor in the ongoing decline in cholesterol levels for Americans.

Disparities in Dyslipidemia Testing in HIV

Disparities in Dyslipidemia Testing in HIV

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Women and minorities with HIV are less frequently tested for dyslipidemia, according to a new study from IDWeek 2016.

ORION-1: PCSK9 Synthesis Inhibitor May Reduce LDL Cholesterol in High-Risk Patients

ORION-1: PCSK9 Synthesis Inhibitor May Reduce LDL Cholesterol in High-Risk Patients

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A mean 51% reduction in LDL cholesterol was seen in the group assigned to the 300 mg dose of inclisiran.

Alcohol Intake Linked to Slow Decline of HDL Cholesterol

Alcohol Intake Linked to Slow Decline of HDL Cholesterol

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An analysis of more than 80,000 Chinese participants found that all alcohol consumption slowed the decline of HDL cholesterol in the body.

HOPE-3: Antihypertensives, Statins Do Not Prevent Cognitive Decline

HOPE-3: Antihypertensives, Statins Do Not Prevent Cognitive Decline

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Antihypertensive drugs and rosuvastatin did not prevent or worsen cognitive decline in those at intermediate risk for CVD.

PCSK9, LDL Cholesterol Link Dependent on Glycemic Control in Type 1 Diabetes

PCSK9, LDL Cholesterol Link Dependent on Glycemic Control in Type 1 Diabetes

For patients with type 1 diabetes, the correlation between PCSK9 and LDL cholesterol is only seen in the highest tertile for HbA1c.

Impact of Changes in HbA1c, BMI Changes on Lipids Increases as Children Age

Impact of Changes in HbA1c, BMI Changes on Lipids Increases as Children Age

As children age, the impact of changes in HbA1c and BMI on LDL cholesterol and non-HDL cholesterol levels increases.

HDL Cholesterol Levels Associated With Mortality Risk

HDL Cholesterol Levels Associated With Mortality Risk

Low and high levels of HDL cholesterol are linked to increased mortality risk, according to a study published in the Journal of the American College of Cardiology.

Child-Parent Screening for Familial Hypercholesterolemia Feasible in Primary Care

Child-Parent Screening for Familial Hypercholesterolemia Feasible in Primary Care

Screening for hypercholesterolemia is feasible at routine child immunization visits in primary care practices.

AHA: Recommendations for Statin Interaction With Other Cardiovascular Medications

AHA: Recommendations for Statin Interaction With Other Cardiovascular Medications

Statins can interact with other drugs prescribed for cardiovascular disease, but there are ways to navigate the issue.

Polypharmacy and Lipid Profiles in Type 2 Diabetes

Polypharmacy and Lipid Profiles in Type 2 Diabetes

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Even if the impact of a given medication on lipid profile is relatively minimal, and therefore unlikely to independently affect ASCVD risk, the cumulative effect is important and cannot be overlooked.

HDL Cholesterol, Triglycerides Associated With Diabetic Kidney Disease Risk

HDL Cholesterol, Triglycerides Associated With Diabetic Kidney Disease Risk

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Levels of triglycerides and HDL cholesterol are independent risk factors for chronic diabetic kidney disease in type 2 diabetes.

Reviewing Treatment for Nonalcoholic Fatty Liver Disease

Reviewing Treatment for Nonalcoholic Fatty Liver Disease

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A range of pharmacologic agents have a potential role in the management of NAFLD.

Type 2 Diabetes Risk Higher With Exposure to LDL Cholesterol-Lowering Genetic Variants

Type 2 Diabetes Risk Higher With Exposure to LDL Cholesterol-Lowering Genetic Variants

LDL cholesterol-lowering genetic variants are associated with increased risk of type 2 diabetes, according to a meta-analysis published in JAMA.

Both Statins, Non-Statin Therapies Effectively Lower LDL Cholesterol

Both Statins, Non-Statin Therapies Effectively Lower LDL Cholesterol

Treatments other than statins also can effectively reduce cardiovascular (CV) risk, according to a review and meta-analysis published in the JAMA.

Efficacy of Evolocumab for Reducing LDL Cholesterol

Efficacy of Evolocumab for Reducing LDL Cholesterol

At week 52, all subgroups saw a change in levels of low-density lipoprotein cholesterol.

Review: Statins Effectively Reduce Risk for Vascular Events

Review: Statins Effectively Reduce Risk for Vascular Events

The researchers found larger absolute benefits for prolonged therapy and also noted that benefits outweigh rare cases of adverse events.

Combination Ezetimibe/Rosuvastatin Beats Rosuvastatin Alone in Hypercholesterolemia

Combination Ezetimibe/Rosuvastatin Beats Rosuvastatin Alone in Hypercholesterolemia

For patients with primary hypercholesterolemia, fixed-dose combination of ezetimibe plus rosuvastatin is more effective than rosuvastatin alone.

Study Indicates PCSK9 Inhibitor Use Is Not Cost-Effective

Study Indicates PCSK9 Inhibitor Use Is Not Cost-Effective

For patients with familial hypercholesterolemia or atherosclerotic cardiovascular disease, PCSK9 inhibitor use is not cost-effective.

USPSTF: Insufficient Evidence for Lipid Screening in Children

USPSTF: Insufficient Evidence for Lipid Screening in Children

The US Preventive Services Task Force (USPSTF) has concluded that the evidence is currently insufficient to weigh the balance of benefits and harms of screening for lipid disorders in children and adolescents (aged 20 years or younger).

Risk for Parkinson's Disease in Diabetes May Be Lower With Statins

Risk for Parkinson's Disease in Diabetes May Be Lower With Statins

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All but one type of statin was associated with a dose-dependent neurprotective benefit against Parkinson's.

Risk for Coronary Artery Disease, Diabetes Tied to Lipid Fractions

Risk for Coronary Artery Disease, Diabetes Tied to Lipid Fractions

Routinely measured lipid fractions may be associated with the risk of coronary artery disease (CAD) and diabetes.

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