Lipids and Cholesterol Archive

Oxidative Stress Associated With Metabolic Syndrome

Oxidative Stress Associated With Metabolic Syndrome

Oxidized low-density lipoprotein (ox-LDL) as a proxy for oxidative stress is associated with metabolic syndrome and its components.

Total, LDL Cholesterol Levels Decreasing in the United States

Total, LDL Cholesterol Levels Decreasing in the United States

Healthier diets may be a factor in the ongoing decline in cholesterol levels for Americans.

Disparities in Dyslipidemia Testing in HIV

Disparities in Dyslipidemia Testing in HIV

Women and minorities with HIV are less frequently tested for dyslipidemia, according to a new study from IDWeek 2016.

ORION-1: PCSK9 Synthesis Inhibitor May Reduce LDL Cholesterol in High-Risk Patients

ORION-1: PCSK9 Synthesis Inhibitor May Reduce LDL Cholesterol in High-Risk Patients

A mean 51% reduction in LDL cholesterol was seen in the group assigned to the 300 mg dose of inclisiran.

Alcohol Intake Linked to Slow Decline of HDL Cholesterol

Alcohol Intake Linked to Slow Decline of HDL Cholesterol

An analysis of more than 80,000 Chinese participants found that all alcohol consumption slowed the decline of HDL cholesterol in the body.

HOPE-3: Antihypertensives, Statins Do Not Prevent Cognitive Decline

HOPE-3: Antihypertensives, Statins Do Not Prevent Cognitive Decline

Antihypertensive drugs and rosuvastatin did not prevent or worsen cognitive decline in those at intermediate risk for CVD.

PCSK9, LDL Cholesterol Link Dependent on Glycemic Control in Type 1 Diabetes

PCSK9, LDL Cholesterol Link Dependent on Glycemic Control in Type 1 Diabetes

For patients with type 1 diabetes, the correlation between PCSK9 and LDL cholesterol is only seen in the highest tertile for HbA1c.

Impact of Changes in HbA1c, BMI Changes on Lipids Increases as Children Age

Impact of Changes in HbA1c, BMI Changes on Lipids Increases as Children Age

As children age, the impact of changes in HbA1c and BMI on LDL cholesterol and non-HDL cholesterol levels increases.

HDL Cholesterol Levels Associated With Mortality Risk

HDL Cholesterol Levels Associated With Mortality Risk

Low and high levels of HDL cholesterol are linked to increased mortality risk, according to a study published in the Journal of the American College of Cardiology.

Child-Parent Screening for Familial Hypercholesterolemia Feasible in Primary Care

Child-Parent Screening for Familial Hypercholesterolemia Feasible in Primary Care

Screening for hypercholesterolemia is feasible at routine child immunization visits in primary care practices.

AHA: Recommendations for Statin Interaction With Other Cardiovascular Medications

AHA: Recommendations for Statin Interaction With Other Cardiovascular Medications

Statins can interact with other drugs prescribed for cardiovascular disease, but there are ways to navigate the issue.

HDL Cholesterol, Triglycerides Associated With Diabetic Kidney Disease Risk

HDL Cholesterol, Triglycerides Associated With Diabetic Kidney Disease Risk

Levels of triglycerides and HDL cholesterol are independent risk factors for chronic diabetic kidney disease in type 2 diabetes.

Type 2 Diabetes Risk Higher With Exposure to LDL Cholesterol-Lowering Genetic Variants

Type 2 Diabetes Risk Higher With Exposure to LDL Cholesterol-Lowering Genetic Variants

LDL cholesterol-lowering genetic variants are associated with increased risk of type 2 diabetes, according to a meta-analysis published in JAMA.

Incidence of Cardiovascular Risk Factors High in Older Adults

Incidence of Cardiovascular Risk Factors High in Older Adults

Blacks have increased incidence of hypertension, diabetes, and dyslipidemia but not atrial fibrillation.

Both Statins, Non-Statin Therapies Effectively Lower LDL Cholesterol

Both Statins, Non-Statin Therapies Effectively Lower LDL Cholesterol

Treatments other than statins also can effectively reduce cardiovascular (CV) risk, according to a review and meta-analysis published in the JAMA.

Efficacy of Evolocumab for Reducing LDL Cholesterol

Efficacy of Evolocumab for Reducing LDL Cholesterol

At week 52, all subgroups saw a change in levels of low-density lipoprotein cholesterol.

Review: Statins Effectively Reduce Risk for Vascular Events

Review: Statins Effectively Reduce Risk for Vascular Events

The researchers found larger absolute benefits for prolonged therapy and also noted that benefits outweigh rare cases of adverse events.

Combination Ezetimibe/Rosuvastatin Beats Rosuvastatin Alone in Hypercholesterolemia

Combination Ezetimibe/Rosuvastatin Beats Rosuvastatin Alone in Hypercholesterolemia

For patients with primary hypercholesterolemia, fixed-dose combination of ezetimibe plus rosuvastatin is more effective than rosuvastatin alone.

Study Indicates PCSK9 Inhibitor Use Is Not Cost-Effective

Study Indicates PCSK9 Inhibitor Use Is Not Cost-Effective

For patients with familial hypercholesterolemia or atherosclerotic cardiovascular disease, PCSK9 inhibitor use is not cost-effective.

USPSTF: Insufficient Evidence for Lipid Screening in Children

USPSTF: Insufficient Evidence for Lipid Screening in Children

The US Preventive Services Task Force (USPSTF) has concluded that the evidence is currently insufficient to weigh the balance of benefits and harms of screening for lipid disorders in children and adolescents (aged 20 years or younger).

Risk for Parkinson's Disease in Diabetes May Be Lower With Statins

Risk for Parkinson's Disease in Diabetes May Be Lower With Statins

All but one type of statin was associated with a dose-dependent neurprotective benefit against Parkinson's.

Risk for Coronary Artery Disease, Diabetes Tied to Lipid Fractions

Risk for Coronary Artery Disease, Diabetes Tied to Lipid Fractions

Routinely measured lipid fractions may be associated with the risk of coronary artery disease (CAD) and diabetes.

FDA Approves Single Monthly Injection of PCSK9 Inhibitor

FDA Approves Single Monthly Injection of PCSK9 Inhibitor

Evolocumab will now be available via the Pushtronex systemâ„¢, designed to deliver 420 mg in a single dose.

Familial Hypercholesterolemia Tied to Significantly Increased CVD Risk

Familial Hypercholesterolemia Tied to Significantly Increased CVD Risk

Patients with heterozygous familial hypercholesterolemia have a significantly increased risk for coronary heart disease and atherosclerotic cardiovascular disease.

Gluten-Free Diet May Mitigate Negative Effect of Celiac Disease on Cholesterol in Type 1 Diabetes

Gluten-Free Diet May Mitigate Negative Effect of Celiac Disease on Cholesterol in Type 1 Diabetes

For children with type 1 diabetes, the negative influence of celiac disease on HDL cholesterol can be improved by adherence to a gluten-free diet.

Low Target LDL Cholesterol May Not Decrease Cardiovascular Risk in All Patients

Low Target LDL Cholesterol May Not Decrease Cardiovascular Risk in All Patients

Risk for cardiovascular events was significantly lower among patients with moderate LDL levels, compared to patients with high LDL levels.

Air Pollution Tied to Impaired Glucose, Lipid Metabolism

Air Pollution Tied to Impaired Glucose, Lipid Metabolism

Particulate matter may alter metabolism of glucose and lipids, especially among those with diabetes.

Higher HDL Cholesterol Associated With Cardiac Risk in Type 2 Diabetes With Low LDL Cholesterol

Higher HDL Cholesterol Associated With Cardiac Risk in Type 2 Diabetes With Low LDL Cholesterol

Increased risk for cardiovascular events and all-cause mortality were observed for patients with type 2 diabetes.

VIDEO: Lipid Management for Patients Taking PCSK9 Inhibitors

VIDEO: Lipid Management for Patients Taking PCSK9 Inhibitors

Robert Eckel, MD, discusses lipid management in the era of PCSK9 inhibitors at AACE 2016.

ASGR1 Mutation Associated With Decreased Levels of Non-HDL Cholesterol

ASGR1 Mutation Associated With Decreased Levels of Non-HDL Cholesterol

Heterozygous mutation carriers have lower levels of non-HDL cholesterol and reduced risk for coronary artery disease.

Effect of HDL Cholesterol on CVD Risk Modulated by Triglycerides, LDL Cholesterol

Effect of HDL Cholesterol on CVD Risk Modulated by Triglycerides, LDL Cholesterol

Cardiovascular disease risk is higher when low HDL cholesterol is accompanied by high triglycerides and LDL cholesterol.

FDA Approves First Generic of Crestor

FDA Approves First Generic of Crestor

The first generic version of Crestor (rosuvastatin calcium) tablets was recently approved by the Food and Drug Administration (FDA).

Cardiovascular Risk Decreased With Lipid Treatment in Type 1 Diabetes

Cardiovascular Risk Decreased With Lipid Treatment in Type 1 Diabetes

Treatment is important for primary prevention even without history of cardiovascular disease, researchers said.

LDL Cholesterol, Triglyceride Reductions in Hypertriglyceridemia Vary by Statin

LDL Cholesterol, Triglyceride Reductions in Hypertriglyceridemia Vary by Statin

Greater LDL cholesterol reductions for rosuvastatin 10 mg to 40 mg vs equal and double doses of atorvastatin and simvastatin.

Middle School Children Should Be Counseled About Healthful Behaviors

Middle School Children Should Be Counseled About Healthful Behaviors

Children who exhibited at least 4 unhealthy behaviors were more likely to be obese and have unfavorable cholesterol levels.

Cardiovascular Events Not Reduced With Evacetrapib in High-Risk Patients

Cardiovascular Events Not Reduced With Evacetrapib in High-Risk Patients

Evacetrapib did lower low-density lipoprotein cholesterol in high vascular risk patients, but did not reduce major cardiovascular events.

Co-Infection With HCV, HIV May Raise Diabetes Risk

Co-Infection With HCV, HIV May Raise Diabetes Risk

Having both diseases raises a patient's chances for developing diabetes.

Remnant Cholesterol May Predict Cardiovascular Event Risk in Type 2 Diabetes

Remnant Cholesterol May Predict Cardiovascular Event Risk in Type 2 Diabetes

Remnant cholesterol predicted coronary artery disease events even after adjustment for presence and extent of disease.

Is Autism a Risk Factor for Type 2 Diabetes?

Is Autism a Risk Factor for Type 2 Diabetes?

Adolescents with autism spectrum disorder appear to be more likely to develop the disease.

More People May Have Inherited Cholesterol Condition Than Previously Thought

More People May Have Inherited Cholesterol Condition Than Previously Thought

Researchers found that roughly 834 500 Americans have the inherited condition.

ANGPTL4 Gene Mutation Carriers May Have Lower Risk for Coronary Artery Disease

ANGPTL4 Gene Mutation Carriers May Have Lower Risk for Coronary Artery Disease

Two studies show carriers of the ANGPTL4 variant have better lipid levels and a lower likelihood of coronary artery disease.

Metabolic Parameters May Be Adversely Affected by Air Pollution

Metabolic Parameters May Be Adversely Affected by Air Pollution

Adverse effects on glucose tolerance, insulin sensitivity, blood lipids observed in Mexican-Americans.

Some Physicians Tend to Undertreat With Statins

Some Physicians Tend to Undertreat With Statins

Some clinical departments tend to undertreat when prescribing statins, according to a study published in the Journal of Clinical Pharmacy and Therapeutics.

Combination Ezetimibe, Simvastatin Reduced Cardiovascular Events in IMPROVE-IT

Combination Ezetimibe, Simvastatin Reduced Cardiovascular Events in IMPROVE-IT

Lipid-lowering therapy with ezetimibe plus simvastatin is associated with improved clinical outcomes, with a reduction in total primary end point events.

Extended-Release Niacin Decreases ApoB-48 Concentration in Type 2 Diabetes

Extended-Release Niacin Decreases ApoB-48 Concentration in Type 2 Diabetes

For patients with type 2 diabetes, a statin plus extended-release niacin lowers apolipoprotein B-48 (apoB-48) concentration compared with a statin alone.

USPSTF Draft Recommendations on Lipid Screening, Statin Use Open for Comment

USPSTF Draft Recommendations on Lipid Screening, Statin Use Open for Comment

There appears to be insufficient evidence for lipid screening in children, while the recommendations for statins varies with age and risk.

FDA Advisory Panel Recommends Against Expanded Indications for Ezetimibe

FDA Advisory Panel Recommends Against Expanded Indications for Ezetimibe

In a 10-5 vote, an FDA panel recommended against expanding indications for ezetimibe and ezetimibe/simvastatin.

Follicle-Stimulating Hormone Linked to LDL Cholesterol in Postmenopausal Women

Follicle-Stimulating Hormone Linked to LDL Cholesterol in Postmenopausal Women

Follicle-stimulating hormone may interact with its receptors and lead to elevated LDL cholesterol in postmenopausal women.

Nutraceuticals Alone or with Ezetimibe May Improve Lipid Profile in Dyslipidemia

Nutraceuticals Alone or with Ezetimibe May Improve Lipid Profile in Dyslipidemia

Researchers noted an improvement in lipid profile for nutraceuticals alone or in combination in statin-intolerant patients.

AAP Recommends Screening for Cholesterol, Depression, HIV in All Children

AAP Recommends Screening for Cholesterol, Depression, HIV in All Children

American Academy of Pediatrics guidelines reflect concerns about obesity, suicide, and more.

Statins May Reduce Cataract Risk

Statins May Reduce Cataract Risk

Simvastatin plus ezetimibe is linked to lower risk for cataract development vs placebo.

Nearly Half of People Who Should Take Cholesterol Drugs Are Not

Nearly Half of People Who Should Take Cholesterol Drugs Are Not

Only half of those who should be using medications to lower cholesterol actually are.

More Work Still Needed Despite Improvements in Cholesterol Levels

More Work Still Needed Despite Improvements in Cholesterol Levels

Adults aged 40 to 59 years did not achieve Healthy People 2020 goals during 2011 to 2014.

Rosuvastatin May Be More Effective for Coronary Plaque Regression

Rosuvastatin May Be More Effective for Coronary Plaque Regression

Rosuvastatin may be more effective than atorvastatin for reversion of coronary atherosclerotic plaques.

Pharmacist-Managed Clinic Helped Patients Maintain LDL, HbA1c Goals

Pharmacist-Managed Clinic Helped Patients Maintain LDL, HbA1c Goals

LDL cholesterol and HbA1c goals were maintained after veterans with type 2 diabetes were discharged from pharmacist-managed clinic.

Social Jetlag May Increase Risk for Diabetes, Heart Disease

Social Jetlag May Increase Risk for Diabetes, Heart Disease

A recent study suggests that disruptive sleep patterns throughout the week could lead to increased risk for diabetes and heart disease.

MI-GENES: Genetic Risk Information May Motivate Patients to Lower LDL Cholesterol

MI-GENES: Genetic Risk Information May Motivate Patients to Lower LDL Cholesterol

Disclosing genetic risk information resulted in lower LDL cholesterol levels in patients at risk for coronary heart disease.

Cash Incentives Yielded Small Decreases in LDL Cholesterol

Cash Incentives Yielded Small Decreases in LDL Cholesterol

Cooperation is key to program's success, but the benefits are modest.

Many Hispanic Patients Undertreated for High Cholesterol

Many Hispanic Patients Undertreated for High Cholesterol

Only one-third to one-half of eligible Hispanic patients studied are taking statins or other lipid-lowering therapies.

Many Elderly Patients With Coronary Heart Disease Not Taking Statins

Many Elderly Patients With Coronary Heart Disease Not Taking Statins

Trends in non-statin lipid-lowering therapy use impacted by negative clinical trial results

Lipid Profiles Associated With Tendon Health

Lipid Profiles Associated With Tendon Health

Altered tendon structure or pain is linked to higher total cholesterol, LDL cholesterol, and triglycerides.

Increased HDL Cholesterol in Menopause May Not Protect Against Heart Disease

Increased HDL Cholesterol in Menopause May Not Protect Against Heart Disease

Increased HDL cholesterol during menopausal transition linked to greater carotid intima-media thickness.

Teen Obesity Correlates With Changes in T-Lymphocyte Profile

Teen Obesity Correlates With Changes in T-Lymphocyte Profile

Obesity linked to elevated absolute values of circulating CD3+ and CD4+ cells.

In CAD, Low HDL Cholesterol, High CRP Increases Mortality

In CAD, Low HDL Cholesterol, High CRP Increases Mortality

Findings in patients with coronary artery disease on statin therapy after undergoing first PCI.

Application for New Dosing Option for Repatha Submitted to FDA

Application for New Dosing Option for Repatha Submitted to FDA

New application seeks approval of a single-injection option for the monthly administration of evolocumab.

Gut Microbiome May Play Role in BMI, Lipid Level Variations

Gut Microbiome May Play Role in BMI, Lipid Level Variations

However, more research is needed to understand how different bacteria affect risk factors for heart disease.

Migraine Frequency, Intensity May Increase With Higher Cholesterol Levels

Migraine Frequency, Intensity May Increase With Higher Cholesterol Levels

Number and intensity of crises reduced in association with reduction in total, LDL cholesterol.

Report Raises Concerns About Cost of New Cholesterol Drugs

Report Raises Concerns About Cost of New Cholesterol Drugs

Newly FDA-approved Repatha and Praluent currently cost more than $14,000 per year.

ACA Ups Diagnosis, Treatment of Chronic Diseases

ACA Ups Diagnosis, Treatment of Chronic Diseases

Higher numbers of insured leading to more treatment of hypertension, high cholesterol and diabetes.

Sugar-Sweetened Beverages Tied to Triglycerides in Children

Sugar-Sweetened Beverages Tied to Triglycerides in Children

Reduction in sugar-sweetened beverage intake over 12 months linked to increase in plasma HDL.

Lipophilic Beats Hydrophilic Statin Therapy in Heart Failure

Lipophilic Beats Hydrophilic Statin Therapy in Heart Failure

Meta-analysis shows superior treatment effects on inflammation, cardiac function.

Metformin Linked to Metabolic Changes That May Lower LDL Cholesterol

Metformin Linked to Metabolic Changes That May Lower LDL Cholesterol

Possible metabolic mechanism includes activation of AMPK, FADS suppression.

Vitamin D Supplementation May Not Benefit Obese Adolescents

Vitamin D Supplementation May Not Benefit Obese Adolescents

Vitamin D supplementation in obese adolescents did not benefit their cardiovascular health or diabetes risk.

Researchers Recommend Changes to 2013 AHA/ACC Guidelines

Researchers Recommend Changes to 2013 AHA/ACC Guidelines

Concerns about overtreatment, overlooking of cholesterol levels.

At Lower Values of Measured LDL Cholesterol, Calculated LDL Varies

At Lower Values of Measured LDL Cholesterol, Calculated LDL Varies

For calculated LDL cholesterol of 30 mg/dL, 95% CI was 24 mg/dL to 60 mg/dL.

Navigating Lipid Guidelines to Improve Management of Dyslipidemia

Navigating Lipid Guidelines to Improve Management of Dyslipidemia

Speakers address the different guidelines for management of dyslipidemia and discuss how best to incorporate them into clinical practice.

Standing More May Improve Blood Glucose, Cholesterol

Standing More May Improve Blood Glucose, Cholesterol

Even with regular exercise, sitting for long periods is linked to higher blood glucose and cholesterol levels.

New Antisense APOC3 Inhibitor Can Decrease Triglycerides

New Antisense APOC3 Inhibitor Can Decrease Triglycerides

The drug, ISIS 304801, demonstrates role of apolipoprotein C-III in managing triglycerides

Adding Ezetimibe to Atorvastatin May Improve CV Outcomes After PCI

Adding Ezetimibe to Atorvastatin May Improve CV Outcomes After PCI

Combination therapy linked to greater coronary plaque regression in Japanese patients.

FDA Approves Alirocumab for Certain Patients With High Cholesterol

FDA Approves Alirocumab for Certain Patients With High Cholesterol

The FDA has approved the first PCSK9 inhibitor to treat certain adults with high cholesterol.

About Half of CV Deaths Preventable in U.S.

About Half of CV Deaths Preventable in U.S.

Elimination of five modifiable risk factors could cut the number of cardiovascular deaths.

Regular Exercise Increases Cholesterol Transfer to HDL in Older Women

Regular Exercise Increases Cholesterol Transfer to HDL in Older Women

There were higher transfers of unesterified and esterified cholesterol to HDL in exercisers vs. sedentary women.

VA, Department of Defense Issue Dyslipidemia Management Guidelines

VA, Department of Defense Issue Dyslipidemia Management Guidelines

Key features include elimination of treatment targets and additional testing only when rationale clear.

Testosterone Plus Fenofibrate Yields Strongest Cardiometabolic Benefit

Testosterone Plus Fenofibrate Yields Strongest Cardiometabolic Benefit

Findings in older men with high cholesterol and low testosterone.

Sulfonylureas May Affect Lipids in Type 2 Diabetes

Sulfonylureas May Affect Lipids in Type 2 Diabetes

Researchers noted an increase in free fatty acids and triglycerides and a decrease in LDL and HDL cholesterol.

FDA Panel Favors Approval of Alirocumab for Hypercholesterolemia

FDA Panel Favors Approval of Alirocumab for Hypercholesterolemia

An FDA advisory committee has recommended approval of alirocumab (Praluent, Regeneron) for treatment of hypercholesterolemia.

Adding Ezetimibe to Statins Beneficial After ACS

Adding Ezetimibe to Statins Beneficial After ACS

Lowering of LDL cholesterol levels, improved CV outcomes for simvastatin plus ezetimibe.

Statins May Lower Mortality Risk After CABG

Statins May Lower Mortality Risk After CABG

Patients taking a statin had lower mortality risk in weeks after the surgery, researchers say.

Stroke Risk Lower in Elderly on Lipid-Lowering Drugs

Stroke Risk Lower in Elderly on Lipid-Lowering Drugs

Older patients had one-third lower risk for stroke when taking statins or fibrates.

Lipids, Vitamin B12, Folate Affected by Iron Deficiency Anemia

Lipids, Vitamin B12, Folate Affected by Iron Deficiency Anemia

Treatment of iron deficiency anemia was linked to improvements in vitamin B12, folate and lipids.

Statins May Benefit Prostate Cancer Patients Receiving ADT

Statins May Benefit Prostate Cancer Patients Receiving ADT

The progression of prostate cancer appeared to be slowed in those taking statins.

Triglycerides Declining Among Americans, CDC Says

Triglycerides Declining Among Americans, CDC Says

Although decreases have been seen in the last decade, many people still remain at risk.

Mortality Rate Down, but Diabetes, CVD Still Prevalent in Baby Boomers

Mortality Rate Down, but Diabetes, CVD Still Prevalent in Baby Boomers

Mixed results indicate that while the mortality rate for "Baby Boomers" is declining, many are taking cardiovascular drugs or have diabetes.

Psoriasis Risk No Lower With Statins

Psoriasis Risk No Lower With Statins

Findings among patients with high, long-term adherence to statins.

Statin Use May Lower Mortality Risk in Lung Cancer

Statin Use May Lower Mortality Risk in Lung Cancer

Statin use has been associated with a lower risk for mortality in lung cancer, but more research is necessary.

Important Research in Endocrinology of 2014

Important Research in Endocrinology of 2014

Author summarizes studies published in 2014 that are relevant to practice of endocrinology.

Age-, Sex-Specific Thresholds May Improve Statin Therapy Recommendations

Age-, Sex-Specific Thresholds May Improve Statin Therapy Recommendations

Sensitivity and specificity of recommendations can be improved with use of specific CVD risk thresholds.

Statins May Be Cost-Effective for CVD Prevention in Older Patients

Statins May Be Cost-Effective for CVD Prevention in Older Patients

Statins would prevent heart attacks and coronary heart diseease and be cost-effective if no increase in geriatric-specific adverse effects.

Hydroxychloroquine May Lower Hyperlipidemia Risk in Early Rheumatoid Arthritis

Hydroxychloroquine May Lower Hyperlipidemia Risk in Early Rheumatoid Arthritis

Reduced risk for hyperlipidemia with hydroxychloroquine vs. other disease-modifying antirheumatic drugs.

Fish Oil May Lower Atherothrombotic Risk

Fish Oil May Lower Atherothrombotic Risk

Potential benefit in suspected coronary artery disease greatest for patients not receiving lipid-lowering therapy.

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