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LEXAPRO
Anxiety/OCD
Mood disorders
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Drug Name:

LEXAPRO Rx

Generic Name and Formulations:
Escitalopram (as oxalate) (single-isomer citalopram) 5mg, 10mg+, 20mg+; tabs (+scored).

Company:
Allergan

Therapeutic Use:

Indications for LEXAPRO:

Generalized anxiety disorder.

Adult:

Initially 10mg once daily; may increase to 20mg once daily after 1 week. Elderly or hepatic impairment: 10mg once daily.

Children:

<18yrs: not established.

Contraindications:

During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.

Warnings/Precautions:

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic or severe renal impairment (CrCl <20mL/min). Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. ECT. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C; avoid 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.

Interactions:

See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.

See Also:

LEXAPRO ORAL SOLUTION

Pharmacological Class:

SSRI.

Adverse Reactions:

Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia; hyponatremia (esp. elderly).

How Supplied:

Tabs—100; Soln—240mL

Indications for LEXAPRO:

Major depressive disorder.

Adult:

Initially 10mg once daily; may increase to 20mg once daily after 1 week. Elderly or hepatic impairment: 10mg once daily.

Children:

<12yrs: not established. 12–17yrs: initially 10mg once daily; may increase to 20mg once daily after 3 weeks.

Contraindications:

During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.

Warnings/Precautions:

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic or severe renal impairment (CrCl <20mL/min). Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. ECT. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C; avoid 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.

Interactions:

See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.

See Also:

LEXAPRO ORAL SOLUTION

Pharmacological Class:

SSRI.

Adverse Reactions:

Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia; hyponatremia (esp. elderly).

How Supplied:

Tabs—100; Soln—240mL

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