Vitamin D Receptor Levels Lower in Alopecia

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Researchers found serum and tissue vitamin D receptor levels in patients with alopecia.
Researchers found serum and tissue vitamin D receptor levels in patients with alopecia.

(HealthDay News) — Patients with alopecia areata (AA) and androgenetic alopecia (AGA) have significantly lower serum and tissue levels of vitamin D receptors, according to a study published in the Journal of Cosmetic Dermatology.

Marwa M.T. Fawzi, MD, from Cairo University, and colleagues examined vitamin D receptors in the skin and blood in 20 patients with AA, 20 with AGA, and 20 healthy controls. Vitamin D receptor levels were detected in blood samples and lesional scalp biopsies.

The researchers found that AA and AGA patients had lower serum and tissue vitamin D receptor levels (P=.000). In each group, serum and tissue vitamin D receptors were positively correlated. Females with AA had significantly lower tissue vitamin D receptors than males (P=.046); females with AGA had significantly higher serum and tissue vitamin D receptor levels than males (P=.004).

"This study suggests an important role for vitamin D receptors in the pathogenesis of AA and AGA through documenting lower serum and tissue vitamin D receptor levels in AA and AGA patients in comparison with controls," the researchers wrote.

Reference

  1. Fawzi MT, Mahmoud SB, Ahmed SF, Shaker OG. Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. J Cosmet Dermatol. 2016. doi:10.1111/jocd.12224.
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