Vitamin D Receptor Levels Lower in Alopecia
Researchers found serum and tissue vitamin D receptor levels in patients with alopecia.
(HealthDay News) — Patients with alopecia areata (AA) and androgenetic alopecia (AGA) have significantly lower serum and tissue levels of vitamin D receptors, according to a study published in the Journal of Cosmetic Dermatology.
Marwa M.T. Fawzi, MD, from Cairo University, and colleagues examined vitamin D receptors in the skin and blood in 20 patients with AA, 20 with AGA, and 20 healthy controls. Vitamin D receptor levels were detected in blood samples and lesional scalp biopsies.
The researchers found that AA and AGA patients had lower serum and tissue vitamin D receptor levels (P=.000). In each group, serum and tissue vitamin D receptors were positively correlated. Females with AA had significantly lower tissue vitamin D receptors than males (P=.046); females with AGA had significantly higher serum and tissue vitamin D receptor levels than males (P=.004).
"This study suggests an important role for vitamin D receptors in the pathogenesis of AA and AGA through documenting lower serum and tissue vitamin D receptor levels in AA and AGA patients in comparison with controls," the researchers wrote.