Vitamin D Deficiency Associated With Asthma Exacerbation

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Vitamin D Deficiency Associated With Asthma Exacerbation
Vitamin D Deficiency Associated With Asthma Exacerbation

(HealthDay News) — Vitamin D deficiency is associated with increased odds of asthma exacerbations, according to a study published in Allergy.

"The impact of low vitamin D status on asthma, asthma morbidity and control is unclear. We aimed to investigate in adults the associations between serum 25-hydroxyvitamin D level and prevalent asthma as well as asthma exacerbations," wrote Ronit Confino-Cohen, MD, from the Meir Medical Center in Kfar Saba, Israel, and colleagues.

The researchers examined the correlations between serum 25-hydroxyvitamin D (25[OH]D) level and asthma in a cohort of Israeli adults aged 22 to 50 years. Participants with physician-diagnosed asthma and asthma exacerbation were identified.

The researchers found that 6.9% of the 308,000 participants with at least one vitamin D measurement had physician-diagnosed asthma, compared with 5.7% in the general population. Serum 25(OH)D levels were similar for those with and without asthma. 

The odds of having an exacerbation were 25% greater for those with vitamin D deficiency than for those with vitamin D levels in the normal range. This significant correlation persisted even after adjustment for confounding variables.

"While there was no significant association between vitamin D status and physician-diagnosed asthma, there was a strong association with asthma exacerbations. The presented evidence supports vitamin D screening in the subgroup of asthmatics that are uncontrolled and experience recurrent exacerbations." the researchers wrote.

Reference

  1. Confino-Cohen R et al. Allergy. 2014;doi:10.1111/all.12508.
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