General Endocrinology

Cushing Syndrome Results in Poor Quality of Life Even After Remission

Cushing Syndrome Results in Poor Quality of Life Even After Remission

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Although patients reach clinical and biochemical remission, patients exposed to hypercortisolism do not show functional remission.

FDA Approves First Mobile App for Use in Preventing Pregnancy

FDA Approves First Mobile App for Use in Preventing Pregnancy

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The algorithm was designed to account for sperm survival, variation in cycle length, ovulation day, temperature fluctuations and the length of the follicular and luteal phases of the menstrual cycle.

Self-Administered Contraceptive Vaginal System Approved for Up to 1 Year of Use

Self-Administered Contraceptive Vaginal System Approved for Up to 1 Year of Use

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The safety and efficacy of Annovera was evaluated in 3 open-label clinical trials involving healthy women (ages 18 to 40).

Plasma Copeptin More Accurate for Diabetes Insipidus Diagnosis

Plasma Copeptin More Accurate for Diabetes Insipidus Diagnosis

In patients with hypotonic polyuria, the direct measurement of hypertonic saline-stimulated plasma copeptin has better diagnostic accuracy than the water-deprivation test.

Metyrapone Reduced Urinary-Free Cortisol Levels in Cushing Syndrome

Metyrapone Reduced Urinary-Free Cortisol Levels in Cushing Syndrome

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The treatment goals for Cushing syndrome are to normalize cortisol levels, reverse clinical symptoms, and if possible to remove the secreting neoplasm.

International PCOS Network Issues New Guidelines for Management and Diagnosis of PCOS

International PCOS Network Issues New Guidelines for Management and Diagnosis of PCOS

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International evidence-based guidelines include 166 recommendations and practice points to improve health outcomes of women with PCOS.

The Association Between Skin Diseases and Metabolic Syndrome

The Association Between Skin Diseases and Metabolic Syndrome

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Investigators examine the association between various skin conditions and metabolic syndrome.

Hepatitis B Infection May Increase the Risk for Pancreatic Cancer

Hepatitis B Infection May Increase the Risk for Pancreatic Cancer

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Investigators assessed the association of hepatitis B infection and pancreatic cancer, along with predictors of pancreatic cancer and mortality.

Men With Migraines May Have Increased Serum Estradiol, Androgen Deficiency

Men With Migraines May Have Increased Serum Estradiol, Androgen Deficiency

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Men with migraines were found to have increased levels of estradiol and to be more likely to have relative androgen deficiency compared with men without migraines.

Young Cancer Survivors Have High Risk of Endocrine Diseases

Young Cancer Survivors Have High Risk of Endocrine Diseases

Adolescent and young adult cancer survivors have a 73 percent higher risk of endocrine diseases.

Preconception Vitamin D Concentrations and Pregnancy Outcomes

Preconception Vitamin D Concentrations and Pregnancy Outcomes

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The association between preconception Vitamin D levels and pregnancy outcomes in women with previous pregnancy losses was examined.

Accuracy of Diagnostic Tests for GH Deficiency in Childhood Cancer Survivors

Accuracy of Diagnostic Tests for GH Deficiency in Childhood Cancer Survivors

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The utility of IGF-I and IGFBP-3 for growth hormone testing in childhood cancer survivors was examined.

Prevalence and Predictors of Renal Calcification in Primary Hyperparathyroidism

Prevalence and Predictors of Renal Calcification in Primary Hyperparathyroidism

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Investigators aimed to assess biochemical predictors of renal calcifications in patients with primary hyperparathyroidism.

Increased Risk for Early Gonadarche Associated With Oxandrolone Treatment

Increased Risk for Early Gonadarche Associated With Oxandrolone Treatment

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Investigators examine the onset of puberty and testicular function in prepubertal boys treated with oxandrolone.

Effects of Menopause on Prolactinoma Treatment Outcomes Post-Dopamine Agonist Withdrawal

Effects of Menopause on Prolactinoma Treatment Outcomes Post-Dopamine Agonist Withdrawal

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Serum prolactin level 6 to 12 months after dopamine agonist withdrawal may be a useful predictor for clinical outcomes in patients with prolactinoma.

Cross-Sex Hormone Therapy May Raise Vascular Event Risk in Transgender Persons

Cross-Sex Hormone Therapy May Raise Vascular Event Risk in Transgender Persons

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The current study sought to compare the incidence of acute cardiovascular events among transgender persons.

Conservative Monitoring Strategy for Non-Functioning Pituitary Adenomas Evaluated

Conservative Monitoring Strategy for Non-Functioning Pituitary Adenomas Evaluated

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Investigators examined whether primary conservative monitoring is a safe strategy in patients with non-functioning pituitary adenomas.

Relationship Between Estradiol Level and Mortality in Elderly Men

Relationship Between Estradiol Level and Mortality in Elderly Men

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Data from a prospective cohort study were used to determine the effect of estradiol levels on all-cause and cause-specific mortality in men aged ≥65 years.

Adjunctive Aripiprazole Lowers Prolactin Levels in Women With Psychosis

Adjunctive Aripiprazole Lowers Prolactin Levels in Women With Psychosis

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These data suggest that aripiprazole can be safely used in premenopausal women to treat elevated prolactin levels and prolactin-related adverse effects.

Placebo Effect of Various Female Sexual Dysfunction Drug Txs Assessed

Placebo Effect of Various Female Sexual Dysfunction Drug Txs Assessed

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For this study, the authors aimed to quantify this effect by conducting a systematic review of various databases to identify studies that included a placebo arm and used Female Sexual Function Index as a clinical outcome.

Hormonal Contraceptives and Migraine: Is It Time to Revisit Stroke Risk?

Hormonal Contraceptives and Migraine: Is It Time to Revisit Stroke Risk?

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Current oral contraceptive products contain lower doses of estrogen than those used in the past, prompting reconsideration of risks and benefits.

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Investigators revised pooled cohort equations to improve clinical accuracy to predict risk for cardiovascular disease.

Many Drugs Made Available Via FDA Expanded Access Programs

Many Drugs Made Available Via FDA Expanded Access Programs

Half of meds ID'd in expanded access programs treat cancer; others for metabolic, endocrine diseases

Screening for Comorbid Conditions Not Adequate in Acromegaly

Screening for Comorbid Conditions Not Adequate in Acromegaly

Investigators examined the frequency of comorbidity screening and the frequency of comorbidities in patients with acromegaly.

Unplanned Pregnancies Prevalent Among HIV-Positive Women

Unplanned Pregnancies Prevalent Among HIV-Positive Women

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Researchers examined unplanned pregnancies and contraceptive use among HIV-positive women in a cross-sectional study.

Reduced Mortality for Women Undergoing Assisted Reproduction Likely Due to "Healthy Patient Effect"

Reduced Mortality for Women Undergoing Assisted Reproduction Likely Due to "Healthy Patient Effect"

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Researchers sought to determine whether the reduced mortality seen in women receiving reproductive assistance occurred as a result of improved general health in this population.

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

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Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

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Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.

Hypoparathyroidism Treatment Granted Orphan Drug Designation

Hypoparathyroidism Treatment Granted Orphan Drug Designation

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TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.

Worse Survival for <i>BRCA</i> Germline Mutation Carriers in Pancreatic CA

Worse Survival for BRCA Germline Mutation Carriers in Pancreatic CA

BRCA1/BRCA2 germline mutation carriers with pancreatic ductal adenocarcinoma have worse survival after resection.

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