Generic Name and Formulations:
Gadobutrol 604.72mg/mL (1mmol/mL); soln for IV inj; preservative-free.
Indications for GADAVIST:
For use with MRI: in adults and children (including term neonates) to detect and visualize areas with disrupted blood brain barrier and/or abnormal vascularity of the CNS; or, to assess the presence and extent of malignant breast disease.
Adults and Children:
Give 0.1mL/kg (0.1mmol/kg) IV at a rate of 2mL/second, followed by a saline flush (to ensure complete injection).
Increased risk of nephrogenic systemic fibrosis among patients with renal impairment (eg, >60yrs, diabetes mellitus, chronic hypertension). Chronic, severe kidney disease (GFR <30mL/min/1.73m2). Acute kidney injury. Screen for renal impairment and other conditions. Do not exceed recommended dose; allow sufficient period of time for elimination prior to re-administration. History of reaction to contrast media, asthma and/or allergic disorders. Have resuscitative equipment available. Monitor for signs/symptoms of hypersensitivity reactions. Avoid extravasation. Gadavist MRI may overestimate extent of malignancy in the diseased breast up to 50% of patients. Elderly. Pregnancy (Cat.C). Nursing mothers.
Do not mix with other drugs.
Paramagnetic contrast agent (Gadolinium-based).
Headache, nausea, dizziness; nephrogenic systemic fibrosis, hypersensitivity reactions.
Single-dose vials (2mL)—15; (7.5mL, 10mL, 15mL)—20; Single-use prefilled syringes (7.5mL, 10mL, 15mL)—5
Endocrinology Advisor Articles
- Imaging Studies in Hypothyroidism Evaluation Linked to Unnecessary Risks
- Insulin Glargine Associated With Breast Cancer Risk in T2D
- Once-Weekly Omarigliptin Improves Glycemic Control in Type 2 Diabetes
- Transoral Endoscopic Thyroidectomy Vestibular Approach: Safety and Outcomes
- High Grip Strength Associated With Lower Risk for Diabetes-Related AEs
- Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk
- Lower Risk for SGLT2i-Associated Genitourinary Infection With DPP-4i
- Severe Hypoglycemia Associated With Increased Mortality Risk in T2D
- Efficacy of CGM in Preterm Infants of Mothers With Diabetes
- Expert Roundtable: AHA Update on Dietary Fat Intake and CVD Risk
- Increased Risk of Diabetes, Post-Diabetes Pneumonia for Patients With COPD
- Pancreatic Exocrine Dysfunction Occurs After Islet Autoimmunity in T1D
- T2D in African American Women Ups ER-negative Breast Cancer Risk
- High-Sensitivity CRP and LDL-C Predictive of Subsequent MACE in T2D
- Risks Associated With Denosumab Discontinuation