Generic Name and Formulations:
Fosinopril sodium, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg; tabs.
Various generic manufacturers
- Antihypertensive "Quadpill" Therapy Highly Effective
- HOPE-3: Antihypertensives, Statins Do Not Prevent Cognitive Decline
- Risk for Secondary Hyperparathyroidism Up With Furosemide Use
- Hypertension Treatments: ACE Inhibitors
- Hypertension Treatments: Diuretics
- Combination Hypertension Treatments
Indications for Fosinopril/Hydrochlorothiazide:
Hypertension. Not for initial therapy.
Give once daily. Usual range: fosinopril: 10–20mg; HCTZ: 12.5–50mg. Severe renal impairment (CrCl<30mL/min): not recommended.
Anuria. Hypersensitivity to ACE inhibitors, sulfonamide-derived drugs.
Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Salt/volume depletion; correct before initiating therapy. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Gout. SLE. Monitor WBCs in renal or collagen vascular disease. Monitor electrolytes, BUN (if high). Pregnancy (Cat.C in 1st trimester; Cat.D in 2nd and 3rd trimester). Nursing mothers: not recommended.
ACE inhibitor + diuretic (thiazide).
Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Antagonized by NSAIDs. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements. May antagonize norepinephrine, methenamine. May potentiate nondepolarizing muscle relaxants. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid tests. Nitritoid reactions with injectable gold.
Headache, cough, fatigue; hyperkalemia, orthostatic hypotension, angioedema (discontinue if occurs).
Formerly known under the brand name Monopril HCT.
Endocrinology Advisor Articles
- Fasting Glycemic Variability Indicates Increased Risk for Type 2 Diabetes
- Heritability of BMI Stronger in Obesogenic Environments
- Adverse Events Associated With Diazoxide Treatment for Congenital Hyperinsulinism
- Maternal Gluten Intake Associated With Risk for Type 1 Diabetes in Offspring
- Domestic Refrigeration May Pose Underestimated Risk for Insulin Quality
- Vitamin D Supplementation Has No Effect on Musculoskeletal Health
- Deep Learning Algorithm Efficiently Detects Vision-Threatening Diabetic Retinopathy
- Industry-Funded Trials Often Involve Employees in Studies
- Nutrition Tips for Physicians: Staying Healthy During Busy Days
- Early-Onset Asthma/Wheezing Associated With Later Childhood Obesity