Reduced Microalbuminuria With Valsartan Therapy in Impaired Glucose Tolerance
Valsartan therapy reduced diabetes incidence, but not cardiovascular events.
HealthDay News — For patients with impaired glucose tolerance (IGT), valsartan is associated with reduced incidence of microalbuminuria, according to a study published online in Diabetes, Obesity and Metabolism.
Gemma Currie, MB, ChB, from the University of Glasgow in the United Kingdom, and colleagues examined the impact of valsartan on kidney outcomes in 9,306 patients with IGT. Participants were randomized to valsartan or placebo and were followed for a median of 6.2 years.
The researchers found that valsartan correlated with a reduction in diabetes incidence, but not in cardiovascular events. End-stage renal disease or doubling of serum creatinine occurred in 0.5% and 0.6% of patients in the valsartan versus placebo groups, respectively (hazard ratio [HR], 0.96; 95% CI, 0.55-1.66; P =.87). Few patients developed an estimated glomerular filtration rate of ≤30 mL/min/1.73 m² or had renal hospitalization. Microalbuminuria developed in fewer patients on valsartan than placebo (5.8% vs 8.4%; HR, 0.68; 95% CI, 0.57-0.80; P <.0001); macroalbuminuria developed in fewer valsartan-treated patients. Urinary albumin to creatinine ratio was 11% lower with valsartan, and 9%lower after adjustment for glucose and blood pressure (both P <.0001).
"Valsartan reduced the incidence of microalbuminuria in IGT without increasing the incidence of hyperkalemia or renal dysfunction compared with placebo," the authors write.
Several authors disclosed financial ties to pharmaceutical companies, including Novartis, which manufactures valsartan and funded the main NAVIGATOR study.
Currie G, Angelyn Bethel M, Holzhauer B, Haffner SM, Holman RR, McMurray JJV. Effect of valsartan on kidney outcomes in people with impaired glucose tolerance [published online January 17, 2017]. Diabetes Obes Metab. doi: 10.1111/dom.12887