Celiac Disease May Raise Risk for Autoimmune Thyroid Disease in Type 1 Diabetes
Patients with celiac disease and type 1 diabetes may face an increased risk for autoimmune thyroid disease.
(HealthDay News) — Celiac disease is a risk factor for development of autoimmune thyroid disease in patients with type 1 diabetes, according to a study published in Diabetes Care.
Matthew Kurien, MD, from the Royal Hallamshire Hospital in Sheffield, U.K., and colleagues examined the risk for autoimmune thyroid disease for individuals with both type 1 diabetes and celiac disease in a population-based cohort study. Data were included for 947 individuals with type 1 diabetes and small intestinal biopsy-verified celiac disease. These patients were matched with 4584 controls with type 1 diabetes but without celiac disease.
The researchers found that celiac disease was a risk factor for later autoimmune thyroid disease in type 1 diabetes. Ninety patients with type 1 diabetes and celiac disease developed autoimmune thyroid disease during follow-up (expected, 54). This corresponded with a hazard ratio [HR] of 1.67 after adjustment for sex, age, and calendar period (95% CI, 1.32-2.11; P<.001).
Those who had celiac disease for 10 years or more had the highest excess risk (HR=2.22; 95% CI, 1.49-3.23). Both men and women experienced increases in risk.
Celiac disease was associated with increased risk for hypothyreosis (HR=1.66; 95% CI, 1.30-2.12) and hyperthyreosis (HR=1.72; 95% CI, 0.95-3.11).
"Among patients with [type 1 diabetes], [celiac disease] is a risk factor for the later development of [autoimmune thyroid disease]," the researchers wrote.