Alefacept May Help Preserve Beta-Cell Function in Type 1 Diabetes
The psoriasis drug preserved pancreatic beta-cell function in some patients with type 1 diabetes.
(HealthDay News) — Taking two 12-week courses of alefacept — a drug already approved to treat psoriasis — may help people with newly diagnosed type 1 diabetes preserve pancreatic beta-cell function, a new study suggests.
The findings were published in the Journal of Clinical Investigation.
The current clinical trial — the second of three required for approval — included 49 people aged 12 and 35 years who were newly diagnosed with type 1 diabetes. Patients were randomly selected to receive the drug or a placebo. Thirty-three people were given the drug for two 12-week courses, with a 12-week gap in between the courses.
Over 2 years of follow-up, the group that received the drug had a lower decline in C-peptide secretion. Moreover, nine out of 30 patients evaluated for C-peptide function showed no decline in C-peptide production, compared with just one of 12 people evaluated in the placebo group.
Preservation of C-peptide lasted as long as 15 months after treatment stopped, lead researcher Mario Ehlers, MD, PhD, of the Indiana University School of Medicine in Indianapolis, said in a news release from the Immune Tolerance Network.
"Achieving long-term benefit following a short course of therapy is a challenging goal," Gerald Nepom, MD, PhD, director of the Immune Tolerance Network, said in the news release.
"Detailed analysis of the T-cell types present in the blood of those who responded to the treatment will help us identify the best way to improve this type of immune therapy for patients with type 1 diabetes and potentially other autoimmune diseases."
Several authors disclosed financial ties to pharmaceutical companies, including Astellas, which manufactures alefacept and partially funded the study.