Preclinical Study Looks for T2D Links to Pancreas Protein

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The study team also injected the protein into pancreatic tissue from healthy human donors and found that IAPP collected in the pancreatic tissue.
The study team also injected the protein into pancreatic tissue from healthy human donors and found that IAPP collected in the pancreatic tissue.

HealthDay News — Amyloid polypeptide (IAPP) deposits in the pancreas may lead scientists to a better understanding of type 2 diabetes, according to research published in the Journal of Experimental Medicine.

IAPP collects in the pancreas in patients with type 2 diabetes, but whether these deposits cause the disease or appear after the disease begins hasn't been clear. Researchers from McGovern Medical School at the University of Texas Health Science Center in Houston injected mice with this protein to try to better define its role in type 2 diabetes.

The investigators found that when the mice received this protein, the animals developed symptoms of type 2 diabetes, such as the death of insulin-producing cells in the pancreas and high blood glucose levels

The study team also injected the protein into pancreatic tissue from healthy human donors and found that IAPP collected in the pancreatic tissue.

"Almost all patients with type 2 diabetes have these protein [deposits], but we don't know if it's a disease pathway or a correlate," study author Claudio Soto, PhD, a professor of neurology at McGovern, told HealthDay. Soto theorized that when insulin production increases, so does IAPP, and the excess IAPP collects in the pancreas. The study team said that a small number of these protein deposits can then encourage the misfolding of additional proteins. Eventually, large deposits can form that damage the beta cells. Soto says more research is needed.

Reference

Mukherjee A, Morales-Scheihing D, Salvadores N, et al. Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. J Exp Med. 2017 Sep 4;214(9):2591-2610.

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