Fasting Glycemia May Be Beneficial for Gestational Diabetes Screening
Fasting glycemia may be an acceptable alternative to 75-g glucose tolerance test for gestational diabetes screening.
(HealthDay News) — Screening for gestational diabetes with fasting glycemia seems to be an acceptable alternative to universal screening with the complete 75-g glucose tolerance test, according to a study published in BJOG: An International Journal of Obstetrics & Gynaecology.
J. Ryser Rüetschi, from the University Hospitals of Geneva, and colleagues collected 2298 complete 75-g glucose tolerance tests from pregnant women at 24 to 28 weeks of gestation. They simulated stopping the test if fasting glycemia was less than 4.4 mmol/L or 5.1 mmol/L or greater, thereby avoiding glucose loading and further glycemia.
The researchers found that within the population, the prevalence of gestational diabetes was 10.9%. Among 251 women with gestational diabetes, fasting glycemia was at least 5.1 mmol/L, between 4.4 mmol/L and less than 5.1 mmol/L, and less than 4.4 mmol/L in 47.4%, 31.1%, and 21.5%, respectively. The sensitivity was 78.5% with performance of the complete test only in women with fasting glycemia between 4.4 mmol/L and less than 5.1 mmol/L; this would avert glucose loading in 63.8% of women.
"Screening with fasting glycemia is an attractive alternative to universal screening with the complete 75-g glucose tolerance test," the researchers wrote. "This strategy is, however, slightly less sensitive than previously reported in higher-risk populations."