Adverse Outcomes Among Gestational Diabetes Patients With Impaired Insulin Sensitivity

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Women with predominant insulin sensitivity defects also had larger infants and higher fasting glucose.
Women with predominant insulin sensitivity defects also had larger infants and higher fasting glucose.

(HealthDay News) – Among women with gestational diabetes mellitus (GDM), impaired insulin sensitivity, but not insulin secretion defects, is associated with a greater risk of adverse outcomes compared with normal glucose tolerance (NGT), according to a study published in Diabetes Care.

Camille E. Powe, MD, from Massachusetts General Hospital in Boston, and colleagues used oral glucose tolerance test-based indices to estimate insulin sensitivity and secretion in 809 women at 24 to 30 weeks of gestation.

 

The researchers found that women with predominant insulin sensitivity defects (51% of GDM) had higher body mass index (BMI) and fasting glucose relative to women with NGT; they also had larger infants (P=.001) and greater risk of GDM-associated adverse outcomes (P=.003). These differences were independent of BMI. BMI, fasting glucose, infant birth weights, and risk of adverse outcomes were similar for women with predominant insulin secretion defects (30% of GDM) and women with NGT.

"Heterogeneity of physiologic processes underlying hyperglycemia exists among women with GDM," the authors write. "GDM with impaired insulin sensitivity confers a greater risk of adverse outcomes."

Reference

  1. Powe CE, Allard C, Battista MC, et al. Heterogeneous contribution of insulin sensitivity and secretion defects to gestational diabetes mellitus. Diabetes Care. 2016; doi:10.2337/dc15-2672.
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