Fetal Hemoglobin Glycation May Predict Hyperglycemic Exposure in Utero

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Fetal Hemoglobin Glycation May Predict Hyperglycemic Exposure in Utero
Fetal Hemoglobin Glycation May Predict Hyperglycemic Exposure in Utero

(HealthDay News) — Glycation of the alpha-chain in fetal hemoglobin is higher in neonates from women with gestational diabetes and may reflect hyperglycemia exposure in utero, according to a study published online in Diabetes Care.

Felix O. Dupont, from the Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke in Canada, and colleagues conducted a case-control study involving 37 women with gestational diabetes and 30 pregnant women with normal glucose tolerance. They measured the percentage of glycated hemoglobin in cord blood using a unique mass spectrometry method.

RELATED: Diabetes Resource Center

The researchers found that in neonates from women with gestational diabetes, glycation of the alpha-chain (GI-alpha) was higher (2.32% vs. 2.20%; P<.01). In the overall cohort, and in each group, Gl-alpha correlated with maternal HbA1c measured at delivery (overall cohort: r=0.67; P<.0001; gestational diabetes group: r=0.66; P<.0001: normal glucose tolerance group: r=0.50; P=.01).

"Thus, Gl-alpha may reflect hyperglycemic exposure during the last weeks of fetal development," the researchers wrote. "Future studies will confirm Gl-alpha is a predictive biomarker of prenatally programmed lifetime metabolic health and disease."

Reference

  1. Dupont FO et al. Diabetes Care. 2014;doi:10.2337/dc14-0549.
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