AlphaB-Crystallin Levels Tied to Diabetic Retinopathy

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Higher levels of alphaB-crystallin are related to diabetic retinopathy.
Higher levels of alphaB-crystallin are related to diabetic retinopathy.

HealthDay News -- Vitreous levels of alphaB-crystallin are significantly higher in eyes of patients with proliferative diabetic retinopathy (PDR) compared with the eyes of controls without diabetes, according to a study published in Clinical & Experimental Ophthalmology.

Wei Chen, PhD, from the Affiliated Hospital of Nantong University in China, and colleagues assessed vitreous samples collected before vitrectomy from 46 eyes of 46 consecutive patients with PDR and 19 patients without diabetes who had vitrectomy for idiopathic macular hole. Enzyme-linked immunosorbent assay was used to measure concentrations of alphaB-crystallin and vascular endothelial growth factor (VEGF).

The researchers found that the vitreous level of alphaB-crystallin was significantly higher in patients with PDR vs controls (P <.0001), as was the vitreous concentration of VEGF (P <.0001). Similarly, the expression levels of both alphaB-crystallin and VEGF were significantly higher in eyes with active PDR than in those with inactive PDR.

"These results suggest a significant increase of alphaB-crystallin in the vitreous fluid of patients with PDR and present a crucial association between alphaB-crystallin and VEGF with angiogenic activity in PDR," the researchers wrote.

Reference

  1. Chen W, Lu Q, Lu L, Guan H. Increased levels of alphaB-crystallin in vitreous fluid of patients with proliferative diabetic retinopathy and correlation with vascular endothelial growth factor [published online December 7, 2016]. Clin Exp Ophthalmol. doi:10.1111/ceo.12891.
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