Nonalbuminuric CKD Increases Cardiovascular Risk in Type 1 Diabetes

Share this content:
Nonalbuminuric CKD increased risk of cardiovascular morbidity and all-cause mortality but not with renal outcomes.
Nonalbuminuric CKD increased risk of cardiovascular morbidity and all-cause mortality but not with renal outcomes.

HealthDay News — Nonalbuminuric chronic kidney disease is associated with increased risk of cardiovascular disease and all-cause mortality, but not renal outcomes, in patients with type 1 diabetes, according to a study published in Diabetes Care.

Lena M. Thorn, MD, from the Folkhälsan Institute of Genetics in Helsinki, and colleagues conducted an observational follow-up of 3,809 patients with type 1 diabetes from the Finnish Diabetic Nephropathy Study. The authors examined the prevalence of nonalbuminuric chronic kidney disease (CKD) and its impact on cardiovascular and renal outcomes and mortality.

The researchers found that 2% of patients had nonalbuminuric CKD at baseline. This correlated with older age, female sex, retinal laser treatment history, cardiovascular events, and number of antihypertensive drugs in use; there was no correlation with blood pressure levels or specific antihypertensive agents.

Nonalbuminuric CKD was not associated with increased risk of albuminuria (hazard ratio, 2.0; 95% confidence interval: 0.9 to 4.4) or end-stage renal disease (HR, 6.4; 95% CI: 0.8 to 53), but did correlate with increased risk of cardiovascular events (HR, 2.0; 95% CI: 1.4 to 3.5) and all-cause mortality (HR, 2.4; 95% CI: 1.4 to 3.9).

"Nonalbuminuric chronic kidney disease is not a frequent finding in patients with type 1 diabetes, but when present, it is associated with an increased risk of cardiovascular morbidity and all-cause mortality but not with renal outcomes," the researchers wrote.

Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which partially funded the study.

Reference

  1. Thorn LM et al. Diabetes Care. 2015; doi: 10.2337/dc15-0641.
You must be a registered member of Endocrinology Advisor to post a comment.

Sign Up for Free e-Newsletters

CME Focus