Two recently-approved diabetes treatments, a semaglutide injection and an insuline aspart injection, are now available in pharmacies across the United States.
Patients with type 2 diabetes who received once-weekly semaglutide had statistically greater reductions in HbA1c and body weight compared with those treated with dulaglutide.
ADA's recommendations reflect the latest advances in evidence-based research to improve care for millions of people with diabetes.
Study assessed the relationship of fasting neuropeptide Y with insulin resistance, β-cell function, and glucagon-like peptide-1 secretion in nonobese female patients with chronic migraine.
Patients who switch to high-deductible health plans have a decrease in health care utilization, though high-severity emergency department visit expenditures increase in people from low-income neighborhoods.
Findings may have implications for social policies to extend paid maternity leave to achieve higher intensity and longer duration of breastfeeding.
Stricter glycemic control during short-term intensive insulin therapy for newly diagnosed type 2 diabetes patients is associated with a higher likelihood of remission at 1 year.
A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models. When tested in mice and dogs, this device successfully reduced glucose levels.
Duration of Prediabetes, Diabetes Independently Associated With Subclinical Atherosclerosis, Cardiac Dysfunction
Data emphasize the importance of early identification and management of those at risk for diabetes and prediabetes in order to limit exposure to the adverse cardiovascular effects of a longer duration of these conditions.
Higher risks for adverse pregnancy outcomes observed in pregnant women taking metformin for pregestational diabetes are not a result of metformin, but diabetes.
A single dose of the dipeptidyl peptidase-4 inhibitor sitagliptin is associated with increased standardized insulin secretion, with no impact on β-cell glucose sensitivity.
There is considerable variation in adherence across medication classes for the treatment of type 2 diabetes, including sulfonylureas, thiazolidinediones, and metformin.
Despite the safety profile of glucagon, researchers found that it is infrequently prescribed in the prehospital and outpatient setting.
There was an independent association between high diet soft drink consumption and the likelihood of having proliferative diabetic retinopathy; there was no association seen between regular soda drink consumption and diabetic retinopathy.
Clinical guidelines should include postpartum screening and management for all cardiovascular risk factors in women diagnosed with gestational diabetes and not restrict it to diabetes.
The initial decision to discontinue Tanzeum was announced in August 2017 due to limited prescribing of the drug and not because of safety concerns.
Living kidney donors have no increased risks for all-cause mortality, cardiovascular disease, hypertension, type 2 diabetes, or adverse psychological health outcomes.
Breast cancer-specific mortality remains higher among women with diabetes who have longer diabetes duration or preexisting cardiovascular disease.
Even modest gains in abdominal fat in HIV-positive men undergoing long-term viral treatment are associated with the development of diabetes.
For adults who are habitually short sleepers, a personalized sleep extension protocol is feasible and may improve diet by reducing sugar intake.
Transcription factor 7 like 2 genetic variants contribute to phenotypic heterogeneity of type 1 diabetes.
Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.
Balance training interventions (supervised and unsupervised) led to significant improvements in a number of physiological measures, ultimately reflected in a decline in fall risk for older adults with T2D.
Patients with type 2 diabetes treated with sulfonylureas may be at a higher risk of contracting tuberculosis, compared with patients treated with metformin.
In patients with an acute coronary syndrome and LDL-C >50 mg/dL, healthcare providers should consider adding ezetimibe to statin therapy to reduce the risk of cardiovascular events.
Hepatitis C is associated with insulin resistance, and elimination of the virus may help re-establish glycemic control in affected patients.
Patients with diabetes had higher rates for all 19 infection categories with the highest incidence rate ratios seen for bone and joint infections, sepsis, and cellulitis.
Among patients with type 2 diabetes initiating antidiabetes drugs, first-line use of metformin has increased since 2005.
Differences in traditional modifiable diabetes risk factors between black and white individuals may contribute to the racial disparity in diabetes incidence in middle age.
Novo Nordisk has announced that the NovoFine 30G 8mm pen needle will be discontinued on or before April 30, 2018.
Weaning to a hydrolyzed formula did not reduce the risk of type 1 diabetes in children with an increased disease risk.
An interactive, personalized simulation can change behavioral intentions among individuals with type 2 diabetes.
Patients identified with increased insulin resistance following intra-articular corticosteroid injection or any systemic steroid treatment might need a special emphasis regarding management and followup.
Patients with acute kidney injury vs those without experienced hypoglycemia more frequently across all anti-diabetes drug regimens.
In this 30-year prospective cohort study, self-reported duration of lactation in women of childbearing age was associated with a lower risk of development of diabetes.
Children with T1D had statistically significantly higher prevalence rates of hypertension, hypercholesterolemia, and used more CV medication compared with a matched diabetes-free reference cohort in the period after the onset of diabetes.
Efforts to reduce takeaway meal consumption in children could have both short-term and long-term health benefits.
In this phase 3 study, statistically and clinically meaningful improvements in HbA1c, body weight, and the proportion of patients achieving goal HbA1c <7% (53mmol/mol) were demonstrated with 2 doses of ITCA 650 vs placebo.
Dasiglucagon is well-tolerated and is associated with an early pharmacodynamic response similar to that of GlucaGen for severe hypoglycemia.
Findings showed that as the estimated glomerular filtration rate decreased and the blood urea nitrogen level increased, the risk for incident diabetes became progressively more pronounced.
A community-based program improves quality of life and self-management in older adults with type 2 diabetes and comorbidities.
A new formulation of exenatide extended-release that is supplied in a once-weekly, single-dose autoinjector device that comes prefilled with a pre-attached hidden needle, is now available.
An individualized approach to glycemic control in type 2 diabetes is likely to reduce costs and improve quality of life.
Unstable housing is associated with an increased likelihood of diabetes-related emergency department visits and hospitalization.
Study evaluated the safety and efficacy of autoantigen-specific therapy with alum-formulated glutamate decarboxylase in nondiabetic children with multiple islet autoantibodies.
Findings accentuate the much greater concern regarding clinical outcomes in participants who did not respond to metformin monotherapy.
Patients with both gout and diabetes are at a much higher risk for stroke and myocardial infarction than with diabetes alone.
The cumulative risk of end-stage renal disease among patients with type 1 diabetes has declined over time in Finland.
A woman presents to the emergency department with lethargy and marked shortness of breath after being discharged from another hospital for pyelonephritis complicated by cardiac arrest.
For patients with type 2 diabetes, all weight categories show increased long-term mortality, with a nadir at a body mass index of 25 to <30.
Well-constructed and individualized nutrition therapy programs were found to effectively reduce HbA1c and BMI in individuals with type 2 diabetes.
For patients with type 1 diabetes, there is a bidirectional association between depression and severe hypoglycemia and hyperglycemia.
The DiRECT study provides the first evidence from a randomized trial of a dietary and lifestyle intervention with remission of type 2 diabetes as a primary outcome.
For patients with type 2 diabetes undergoing non-cardiac surgery, premedication with liraglutide is associated with reduced median plasma glucose 1 hour postoperatively.
The rates of 3 major complications at less than 30 days after bariatric surgery are low and vary among surgical procedures.
Antidiabetic agents for the treatment of diabetes including maintenance and max doses.
A smart exendin-4 delivery device is a promising therapeutic option for type 2 diabetes that can provide safe, long-term, and on-demand Ex4 therapy.
The FDA has granted marketing clearance of the first shock wave device intended for use in the treatment of chronic, full-thickness diabetic foot ulcers.
A previous diagnosis of asthma increases the risk for subsequent type 1 diabetes by 41%, but a previous diagnosis of type 1 diabetes decreases the risk of subsequent asthma by 18%.
Researchers assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from 14,094 patients.
Risk of cardiovascular events in people with type 2 diabetes and subgroups of coronary artery disease was examined.
Steglatro is indicated as adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, and Steglujan is indicated as adjunct when treatment with both ertugliflozin and sitagliptin are appropriate.
While there is increasing positive data for the utilization of ranolazine, a majority of the data did not come from large randomized controlled trials that looked at metabolic parameters as their primary end point.
In older adults, in whom T1D is rare, patients with diabetes who are positive for autoantibodies are as likely to be false positive with T2D as true positive with T1D.
Corticosteroids should be used with caution in patients with diabetes and mitigating factors should be considered.
Network meta-analysis provided some information on differences between DPP-4 inhibitors, traditional anti-diabetes agents, and placebo in bone fracture.
Patients from 3 sites participated in a trial examining the noninferiority of telemedicine vs standard outpatient care for diabetic foot ulcer follow-up treatment.
A life-course study evaluated the contribution of vascular endothelial dysfunction and inflammation to the development of hypertension in type 1 diabetes.
Urinary albumin-to-creatinine ratio can be independently associated with various adverse CV outcomes.
Although sharing of real-time continuous glucose monitoring data can create tension between patients with type 1 diabetes and family members, it can also facilitate greater empowerment and perceptions of safety among both patients and their caregivers.
Patients with T1D are not susceptible to accelerated lipolysis and ketogenesis, despite the reduction in overnight basal insulin doses during SGLT2i treatment.
Study sought to determine the optimal dosing of linagliptin for the treatment of children with type 2 diabetes.
Patients with diabetes report worse quality of life with more intensified treatment, demonstrating the importance of measuring quality of life outcomes when evaluating diabetes treatments.
As many as one-quarter of individuals with diabetes will experience painful neuropathic symptoms for which treatment is limited.
Investigators sought to examine whether individuals with prediabetes, based on A1c and fasting plasma glucose levels, would have a diagnosis of diabetes when using a 2-hour plasma glucose test.
Study sought to evaluate whether baseline autonomic dysfunction was predictive of future increases in urine albumin-creatinine ratio in pediatric patients with type 1 diabetes.
In patients with diabetes, coronary artery bypass grafting may be the preferred method of revascularization, with lower rates of major adverse cardiac or cerebrovascular events.
No convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with the risk of type 2 diabetes above the level expected.
A randomized controlled trial evaluated whether treatment intensification with biphasic insulin aspart 30 improved glycemic control in patients with type 2 diabetes.
Participants reported improvements in many psychosocial variables associated with using an automated bihormonal bionic pancreas system relative to self-management of diabetes using their own insulin pump.
There were no significant differences in coronary disease-specific health status or dyspnea benefits of chronic total occlusion PCI in patients with and without diabetes.
Investigators sought to delay or prevent the onset of type 1 diabetes by administering a once-daily oral insulin tablet.
Findings from a new study suggest that episodes of severe hypoglycemia in patients with diabetes are associated with high rates of subsequent cardiovascular events.
A study sought to clarify whether total physical activity during the day is equally as important as achieving high levels of intensity associated with moderate-to-vigorous physical activity.
Representatives from multiple associations and societies have issued a new report standardizing clinically meaningful outcome measures for type 1 diabetes, beyond using HbA1c testing.
Lifestyle modification and medications can reduce the incidence of diabetes in adults at risk, although the effects of medications are short-lived.
A prospective cohort study was conducted to determine if 1 hour vs 2 hour blood glucose levels were better for predicting the development of type 2 diabetes.
Patients with diabetes taking saxagliptin, sitagliptin, second-generation sulfonylureas, pioglitazone, and long-acting insulin were assessed for the risk of acute myocardial infarction.
A strong association was found in study between poor survival in elderly patients with type 2 diabetes and cardiovascular complications, especially heart failure.
Drug approval was granted through an abbreviated approval pathway, based on Humalog clinical data.
Study underscores the need to focus on the peer context to understand the functioning of youths with type 1 diabetes.
Incentive-based approaches developed to improve daily adherence to a single behavioral process, such as blood glucose monitoring in adolescents, may not be as effective as multicomponent interventions that address emotional, social, and family processes of diabetes self-management.
Investigators review the safety and efficacy of non-pharmacologic therapy, oral antidiabetic medications, and insulin in women with gestational diabetes.
Investigators believe that type 2 diabetes risk assessment would be optimal with fasting glucose and HbA1c levels.
Recommendations for utilizing trend arrow data in a mobile continuous glucose monitoring system were recently issued for pediatric patients with type 1 diabetes.
Patients with prior experience using a continuous glucose monitoring system may benefit from the MiniMed 670G HCL system therapy.
A remotely connected diabetes management system increased patent satisfaction and improved glycemic control in patients with insulin-treated diabetes.
Interpreting trend arrow data from continuous glucose monitoring may provide additional data to improve glycemic control in adults with diabetes mellitus.
Bone mineral density was evaluated annually of the lumbar spine and femoral neck.
Investigators discuss an added benefit of using DPP4 inhibitors would be a lower incidence of hypoglycemia.
Endocrinology Advisor Articles
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- Pregnancy Rates in Women Undergoing IVF With Fresh vs Frozen Embryos
- Effect of Sugar-Sweetened Beverages on Obesity Development
- Increased Risk for Severe Hypoglycemic Events Associated With CV Outcomes
- Osteoporosis Management: Tailoring a Sequenced Treatment Approach
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- SGLT2 Inhibitors Show High Cardiovascular- and Renal-Protective Effects in T2D
- Two New Diabetes Medications Now Available
- Managing Acute Pain in Patients With Severe Obesity
- Gestational Diabetes May Increase Risk for Hypertension, Ischemic Heart Disease, T2D
- Evaluating the Longitudinal Effects of Diabetes on Cognition
- Denosumab May Increase BMD in Women With Primary Hyperparathyroidism
- Case Challenge: Obesity and Shortness of Breath in a 52-Year-Old Man
- Diabetes Mortality Trends in Adults With Low eGFR, No Albuminuria
- Patients Report Major Concerns With Physicians