Diabetes Archive

Increased Risk for Parkinson Disease in Individuals With Type 2 Diabetes

Increased Risk for Parkinson Disease in Individuals With Type 2 Diabetes

A retrospective cohort study was conducted to determine whether individuals with preexisting type 2 diabetes are at increased risk of developing Parkinson disease.

Associated Outcomes for Metformin-Based Diabetes Treatment After Kidney Transplant

Associated Outcomes for Metformin-Based Diabetes Treatment After Kidney Transplant

Outcomes associated with metformin use for diabetes in patients requiring kidney transplantation were assessed in an observational study linking Scientific Registry of Transplant Recipient data with US pharmacy claims data.

Empagliflozin, Linagliptin Combination Therapy vs Linagliptin Monotherapy for Type 2 Diabetes

Empagliflozin, Linagliptin Combination Therapy vs Linagliptin Monotherapy for Type 2 Diabetes

Investigators examined the safety and efficacy of empagliflozin 10mg and linagliptin 5 mg in patients uncontrolled on linagliptin.

Cleared Blood Glucose Monitor Systems Not Always Accurate

Cleared Blood Glucose Monitor Systems Not Always Accurate

One in three commercially available blood glucose monitor systems meet a predefined accuracy standard.

Kidney Function Decline Occurs Nearly Twice as Fast in Diabetes

Kidney Function Decline Occurs Nearly Twice as Fast in Diabetes

Long-term kidney disease trajectories were examined in patients with and without diabetes.

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

Patients with remitted bipolar disorder and emotional hyper-reactivity also have significantly higher levels of low-grade inflammation, hypertension, and impaired glucose metabolism, indicating a higher risk for cardiometabolic dysfunction.

Single Blood Sample Highly Predictive for Subsequent Diabetes Diagnosis

Single Blood Sample Highly Predictive for Subsequent Diabetes Diagnosis

A recent study supports the clinical use of a combination of fasting glucose and HbA1c levels from a single blood sample to identify undiagnosed diabetes.

LV Strain, Hypertrophy Predict Heart Failure in Asymptomatic T2D

LV Strain, Hypertrophy Predict Heart Failure in Asymptomatic T2D

Impaired global longitudinal strain and left ventricular hypertrophy may be predictive of incident heart failure in patients with asymptomatic type 2 diabetes.

Adjunctive Metformin for Insulin Resistance in T1D: A Clinical Perspective

Adjunctive Metformin for Insulin Resistance in T1D: A Clinical Perspective

Although metformin has been studied in randomized trials as adjunctive therapy to insulin in individuals with type 1 diabetes, further investigation in the form of outcomes trials is necessary to assess risks vs benefits.

AMA: Federal Government Must Tackle Rising Insulin Prices

AMA: Federal Government Must Tackle Rising Insulin Prices

U.S. officials need to take action to control spiking insulin prices, the American Medical Association says.

Diabetes Medication Reconciliation May Reduce Risk of ED Visits

Diabetes Medication Reconciliation May Reduce Risk of ED Visits

The correlation between the fraction of outpatient diabetes medications reconciled over a six-month period and the composite primary outcome over the subsequent six months was assessed.

SGLT2 Inhibitor Use Linked to Lower Risk for Heart Failure, Death in Type 2 Diabetes

SGLT2 Inhibitor Use Linked to Lower Risk for Heart Failure, Death in Type 2 Diabetes

Regardless of presence of preexisting cardiovascular disease, SGLT2 inhibitors were associated with lower risk for death and heart failure.

IV Fluid Infusion Rates Do Not Affect Pediatric DKA Neurologic Outcomes

IV Fluid Infusion Rates Do Not Affect Pediatric DKA Neurologic Outcomes

Neurologic outcomes in children with diabetic ketoacidosis are similar regardless of the rate of administration or the sodium chloride content of intravenous fluids.

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

To understand the mechanism underlying the benefit of fenofibrate on vascular complications in patients with type 2 diabetes, investigators assessed carotid intima thickness as a marker of subclinical atherosclerosis.

Cancer Development Linked to Increased Diabetes Risk

Cancer Development Linked to Increased Diabetes Risk

Researchers examined whether development of cancer is associated with an increased risk of subsequent diabetes in a nationally representative sample of the Korean population.

Does Metformin Use Increase the Risk for Lactic Acidosis in T2D Patients?

Does Metformin Use Increase the Risk for Lactic Acidosis in T2D Patients?

Results demonstrated an incidence rate of 391/100,000 person years was calculated based on the 163 patients who were hospitalized with lactic acidosis during the follow-up period.

Diabetes Exposure in Utero and Risk of Developing T2D in Offspring

Diabetes Exposure in Utero and Risk of Developing T2D in Offspring

This study demonstrated the importance of early screening and diagnosis of type 2 diabetes in mothers and their offspring.

Safety of DPP-IV Inhibitor, Cardiovascular Events After ACS in Type 2 Diabetes

Safety of DPP-IV Inhibitor, Cardiovascular Events After ACS in Type 2 Diabetes

Investigators examined the time to first event composing of cardiovascular death, myocardial infarction, or stroke.

Abnormal Glucose Regulation Associated With Cognitive Dysfunction in HIV+ Men

Abnormal Glucose Regulation Associated With Cognitive Dysfunction in HIV+ Men

A study sought to determine the relationship between glycemic status and cognition in people living with HIV.

Predictors of Success for Insulin-to-Liraglutide Switch for Type 2 Diabetes

Predictors of Success for Insulin-to-Liraglutide Switch for Type 2 Diabetes

Investigators examined predictors of success of switching from insulin to liraglutide in patients with type 2 diabetes.

Pre-Pregnancy Programs May Improve Outcomes in Women With Type 2 Diabetes

Pre-Pregnancy Programs May Improve Outcomes in Women With Type 2 Diabetes

Investigators developed a community-based pre-pregnancy care program to improve pregnancy outcomes.

Diabetes Treatments

Antidiabetic agents for the treatment of diabetes including maintenance and max doses.

MK-1293 Insulin Glargine is a Safe and Effective Treatment Option for Type 2 Diabetes

MK-1293 Insulin Glargine is a Safe and Effective Treatment Option for Type 2 Diabetes

Investigators sought to determine the safety and efficacy of MK-1293 insulin glargine and Lantus in type 2 diabetes.

Thyroid Markers Predicting Gestational Diabetes Risk Identified

Thyroid Markers Predicting Gestational Diabetes Risk Identified

Higher fT3 levels, fT3:fT4 ratios, and second trimester isolated hypothyroxinemia during pregnancy are predictive markers of gestational diabetes.

Stressful Life Events in Childhood and Development of Type 1 Diabetes

Stressful Life Events in Childhood and Development of Type 1 Diabetes

Children of parents experiencing stressful and severe life events in early childhood may be at risk for type 1 diabetes developing.

Contribution of Low-Severity Gestational Diabetes Mellitus on the Diabetes Epidemic

Contribution of Low-Severity Gestational Diabetes Mellitus on the Diabetes Epidemic

Greater awareness of clinical and cost implications of gaps for patients with lower-severity gestational diabetes may improve postdelivery testing and referral.

T1D Self-Management Varies With Adult Developmental Stages

T1D Self-Management Varies With Adult Developmental Stages

Researchers examined patterns of diabetes self-management behaviors and predictors of glycemic control in 7,153 adults enrolled in the Type 1 Diabetes Exchange clinic registry.

Semaglutide May Induce Weight Loss in Type 2 Diabetes Despite BMI

Semaglutide May Induce Weight Loss in Type 2 Diabetes Despite BMI

Researchers assessed whether semaglutide-induced weight loss was related to gastrointestinal adverse events.

FDA Clears Omnipod DASH System for Diabetes Management

FDA Clears Omnipod DASH System for Diabetes Management

The Omnipod DASH system consists of a discreet, tubeless, waterproof Pod which is worn on the body, and the Personal Diabetes Manager (PDM), a handheld wireless device used to control the Pod.

Cardiovascular Mortality in Individuals With Early-, Late-Onset Prediabetes

Cardiovascular Mortality in Individuals With Early-, Late-Onset Prediabetes

Investigators examined the frequency of cardiovascular vs noncardiovascular deaths in individuals who developed prediabetes that did not progress to diabetes.

Composite HbA1c End Point Can Better Gauge Response to Basal Insulin in Type 2 Diabetes

Composite HbA1c End Point Can Better Gauge Response to Basal Insulin in Type 2 Diabetes

Investigators sought to determine baseline and clinical characteristics associated with response to insulin glargine in patients with type 2 diabetes.

Effect of Testosterone Replacement on Glycemic Control in Obese Men With Hypogonadism, T2D

Effect of Testosterone Replacement on Glycemic Control in Obese Men With Hypogonadism, T2D

Investigators examined the effect of testosterone replacement therapy on metabolic syndrome and vascular function in obese males with hypogonadism.

Tailored Letter May Improve Gestational Weight Gain in Gestational Diabetes

Tailored Letter May Improve Gestational Weight Gain in Gestational Diabetes

A tailored electronic health record letter may improve gestational weight gain and reduce postpartum weight retention.

Elevated HbA1c Usually Leads to Prompt Treatment Stratification, Intensification

Elevated HbA1c Usually Leads to Prompt Treatment Stratification, Intensification

Most patients are newly initiated on antidiabetic therapy or have antidiabetic therapy intensified within six months of hemoglobin A1c elevation.

Oral Semaglutide Tops Empagliflozin for HbA1c Improvement: PIONEER 2 Trial

Oral Semaglutide Tops Empagliflozin for HbA1c Improvement: PIONEER 2 Trial

Oral semaglutide 14 mg led to statistically significant improvement in hemoglobin A1c levels and weight loss in adults with type 2 diabetes.

Fewer Major Adverse Cardiovascular Events With New Antihyperglycemic Drugs With Lower Hypoglycemic Risk

Fewer Major Adverse Cardiovascular Events With New Antihyperglycemic Drugs With Lower Hypoglycemic Risk

Investigators proposed that reduction in MACE may be proportional to the magnitude of HbA1c reduction seen with newer antihyperglycemic agents.

Blood Glucose Levels Unaffected by Non-Nutritive Sweeteners

Blood Glucose Levels Unaffected by Non-Nutritive Sweeteners

Researchers analyzed 29 randomized controlled trials with 741 participants to quantitatively synthesize evidence on the glycemic impact of NNSs.

Heart Rate Variability in Type 2 Diabetes

Heart Rate Variability in Type 2 Diabetes

Researchers conducted a systemic review and met-analysis to examine the effect of type 2 diabetes on heart rate variability.

Asymptomatic Hypoglycemia Risk With Frequent Hypoglycemia in T1D

Asymptomatic Hypoglycemia Risk With Frequent Hypoglycemia in T1D

Investigators recorded hypoglycemic symptoms and monitored blood sugar levels by continuous glucose monitoring for 6 days.

Increased Risk for Type 2 Diabetes in Adolescents, Young Adults With ADHD

Increased Risk for Type 2 Diabetes in Adolescents, Young Adults With ADHD

These findings can inform clinical practice in that type 2 diabetes should be considered in ADHD even in the absence of other known risk factors.

Ideal Systolic Blood Pressure for CVD Prevention in Diabetes, Hypertension

Ideal Systolic Blood Pressure for CVD Prevention in Diabetes, Hypertension

Investigators sought to determine whether targeting systolic blood pressure of 140 mmHg in patients with type 2 diabetes would result in adverse CV outcomes.

Inverse Link for Plasma 25(OH)D Concentration, Risk of T2D

Inverse Link for Plasma 25(OH)D Concentration, Risk of T2D

Researchers performed a cohort study involving 903 adults who were known to be free of diabetes or prediabetes during a visit conducted in 1997 to 1999.

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

Researchers examined the incidence and costs of hospital admissions associated with diabetic ketoacidosis admissions.

Insulin Pen Devices

Insulin Pen Devices comparison chart for patients with diabetes mellitus.

Perioperative Cardiovascular Events More Common in Diabetes

Perioperative Cardiovascular Events More Common in Diabetes

Perioperative major adverse cardiovascular and cerebrovascular events may be more common in patients with diabetes.

Individuals With Type 1 Diabetes See Improvement With Continuous Glucose Monitoring

Individuals With Type 1 Diabetes See Improvement With Continuous Glucose Monitoring

Investigators seek to determine he effects of continuous glucose monitoring on daytime and nocturnal hypoglycemia in patients with type 1 diabetes.

Oral T1D Treatment Zynquista to Be Reviewed by FDA

Oral T1D Treatment Zynquista to Be Reviewed by FDA

The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.

Diabetes, HbA1c Independently Associated With Adverse Postoperative Outcomes

Diabetes, HbA1c Independently Associated With Adverse Postoperative Outcomes

Investigators sought to determine an association between diabetes and HbA1C with postoperative outcomes.

Childhood Overweight Increases Risk for Type 2 Diabetes in Adulthood

Childhood Overweight Increases Risk for Type 2 Diabetes in Adulthood

Investigators examined changes in weight from childhood to early adulthood and the risk for developing type 2 diabetes.

Semaglutide Superior to Other GLP-1 Analogues as Add-On to Basal Insulin in T2D

Semaglutide Superior to Other GLP-1 Analogues as Add-On to Basal Insulin in T2D

Overall, once-weekly semaglutide 1.0 mg as an add-on to basal insulin is the most efficacious GLP-1 receptor agonist in terms of reductions in HbA1c and body weight from baseline after 6 months of treatment.

Clinician Perspective: Examining the Link Between Antipsychotics and Diabetes

Clinician Perspective: Examining the Link Between Antipsychotics and Diabetes

Endocrinologist Kevin M. Pantalone, DO, and psychiatrist Christian Kohler, MD, discuss the risk associated with the use of antipsychotic medications in individuals with type 2 diabetes.

ADA Issues White Paper Addressing Escalating Cost of Insulin

ADA Issues White Paper Addressing Escalating Cost of Insulin

There is a lack of transparency throughout the insulin supply chain. It is unclear precisely how the dollars flow and how much each intermediary profits.

Triple-Goal Achievement Reduces Risk for Complications in Type 2 Diabetes

Triple-Goal Achievement Reduces Risk for Complications in Type 2 Diabetes

Treatment strategies targeting hypertension, hyperlipidemia, and hyperglycemia may improve outcomes in patients with type 2 diabetes.

Inverse Association Between Serum 25(OH)D Levels and Risk for Diabetes

Inverse Association Between Serum 25(OH)D Levels and Risk for Diabetes

Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes.

Glycemic Control Variations for Children, Adolescents With T1D in High-Income Countries

Glycemic Control Variations for Children, Adolescents With T1D in High-Income Countries

Investigators examined glycemic control variations in 8 high-income countries from multicenter registries in children with type 1 diabetes.

Use of In-Hospital Continuous Subcutaneous Insulin Infusion: A Consensus Statement

Use of In-Hospital Continuous Subcutaneous Insulin Infusion: A Consensus Statement

To date, published experience with continuous subcutaneous insulin infusion use in the hospital is limited to just a few institutions, and primarily to those instances involving transitioning of the therapy from the outpatient to inpatient setting.

Dual-Hormone System May Lower Time in Hypoglycemia in T1D

Dual-Hormone System May Lower Time in Hypoglycemia in T1D

For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia.

Community Health Worker-Led Intervention Beneficial in T2D

Community Health Worker-Led Intervention Beneficial in T2D

A community health worker-led diabetes self-management education program is associated with sustained improvement in hemoglobin A1c.

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.

Better Control With DPP-4 Inhibitors vs NPH Insulin in Type 2 Diabetes

Better Control With DPP-4 Inhibitors vs NPH Insulin in Type 2 Diabetes

Patients initiating DPP-4 inhibitors as third-line therapy in type 2 diabetes appeared to have lower discontinuation rates and less hypoglycemia compared with patients starting NPH insulin.

Achieving Glycemic Control in T2D After Basal Insulin Initiation

Achieving Glycemic Control in T2D After Basal Insulin Initiation

Maintaining a basal insulin regimen over 12 or 24 months in a patient who has not yet reached the HbA1c <7% target provides little additional benefit toward reaching this goal.

Gestational Diabetes May Indicate Future Subclinical Renal Issues

Gestational Diabetes May Indicate Future Subclinical Renal Issues

The researchers found that, compared with women without gestational diabetes or subsequent diabetes, women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate.

Lesbian, Bisexual Women More Likely to Develop T2D at Younger Age

Lesbian, Bisexual Women More Likely to Develop T2D at Younger Age

Researchers found that the risk of developing type 2 diabetes was increased for lesbian and bisexual women vs heterosexual women.

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

For children and adults with type 1 diabetes, consuming a very low-carbohydrate diet is associated with exceptional glycemic control.

Type 2 Diabetes Increases Risk for Renal Cancer in Women, but Not Men

Type 2 Diabetes Increases Risk for Renal Cancer in Women, but Not Men

Type 2 diabetes is independently associated with a greater risk of renal cell carcinoma in women, but not in men.

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.

Findings Do Not Support Glyburide as First-Line Treatment for Gestational Diabetes

Findings Do Not Support Glyburide as First-Line Treatment for Gestational Diabetes

Findings do not support noninferiority of glyburide for prevention of perinatal complications of gestational diabetes.

Novel Signal Identified for Microalbuminuria in Europeans With T2D

Novel Signal Identified for Microalbuminuria in Europeans With T2D

In European T2D cases, the researchers identified a novel signal near GABRR1, which was associated with microalbuminuria.

Reproductive Markers Associated With Risk of Diabetes

Reproductive Markers Associated With Risk of Diabetes

Markers of reproductive history, including age of menarche and parity, may be tied to future diabetes risk in women with a body mass index ≥25.

Antipsychotic Use and Gestational Diabetes: Is There a Link?

Antipsychotic Use and Gestational Diabetes: Is There a Link?

Results showed there was a significant crude risk linked to continuing vs discontinuing certain antipsychotics and developing gestational diabetes; for quetiapine the risk was 7.1% vs 4.1% (adjusted relative risk [ARR] 1.28), respectively; among olanzapine users it was 12% vs 4.7% (ARR 1.61), respectively.

Improved glycemic control in type 1 diabetes with very low-carbohydrate diets

A survey of individuals with type 1 diabetes consuming a very low-carbohydrate diet indicated that many study participants were able to maintain glycemic control within national ideal glycemic target ranges.

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza

Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

The paradoxical finding of accelerated wound healing and increase in HbA1c in participants with better baseline glycemic control requires confirmation in further studies.

Perioperative MACCEs More Common With Diabetes

Perioperative MACCEs More Common With Diabetes

Perioperative major adverse cardiovascular and cerebrovascular events are more common among patients with diabetes.

Insulins

Insulin products chart with pharmacokinetic properties.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

Brief Educational Intervention Improves Awareness in Severe Hypoglycemia in T1D

Brief Educational Intervention Improves Awareness in Severe Hypoglycemia in T1D

Brief structured education in addition to informed support in active insulin dose self-adjustment underpinned by targeted self-monitoring of blood glucose lead to sustained falls in severe hypoglycemia rates in individuals at high risk.

High Risk of Death After Major Diabetes-Related Amputations

High Risk of Death After Major Diabetes-Related Amputations

There is a high risk of postoperative mortality among patients undergoing lower-limb amputation.

Glyburide is not noninferior to insulin in reducing perinatal complications in gestational diabetes

In this randomized controlled trial, glyburide was not noninferior in terms of the composite rate of macrosomia, neonatal hypoglycemia, and hyperbilirubinemia compared with subcutaneous insulin.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

Irregular Menstruation Common in Girls With Type 2 Diabetes

Irregular Menstruation Common in Girls With Type 2 Diabetes

Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes, and does not improve with 2years of anti-hyperglycemic treatment.

Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D

Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D

The study highlights mitochondrial and autophagic differences in the muscles of young adults with type 1 diabetes with moderate glycemic control who exceed recommended activity levels.

SGLT2 Inhibitors Canagliflozin, Dapagliflozin Compared in Real-World Study

SGLT2 Inhibitors Canagliflozin, Dapagliflozin Compared in Real-World Study

Study compared the real-world effectiveness of canagliflozin 300 mg vs dapagliflozin 10 mg on HbA1c reduction in patients with type 2 diabetes.

Challenges of Long-Distance Air Travel With Type 1 Diabetes

Challenges of Long-Distance Air Travel With Type 1 Diabetes

Long-distance air travel presents numerous unique challenges for insulin-treated patients with diabetes. More accessible and adequate sources of guidance are needed to facilitate travel planning among this patient population.

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Researchers used multiparametric cardiovascular magnetic resonance imaging to examine the correlation between aortic stiffness and LV geometry in younger adults with type 2 diabetes.

Metabolic Syndrome and Skin Disorders: Association Is More Than Skin Deep

Metabolic Syndrome and Skin Disorders: Association Is More Than Skin Deep

Knowing that certain characteristics increase the risk for dermatology patients who may have metabolic syndrome will enable clinicians to identify patients who may have specific cardiovascular risks.

Age- and Weight-Based Screening Identifies Half With Prediabetes

Age- and Weight-Based Screening Identifies Half With Prediabetes

Targeted diabetes screening based only on age and weight criteria will identify approximately half of US adults with dysglycemia.

In LVSD, Diabetes Tied to Higher Risk of Heart Failure

In LVSD, Diabetes Tied to Higher Risk of Heart Failure

In patients with asymptomatic left ventricular systolic dysfunction, diabetes is associated with an increased risk of developing heart failure.

CDC Reports on Diabetes Prevalence by Type in the United States

CDC Reports on Diabetes Prevalence by Type in the United States

The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Results suggest that circadian preference and meal timing are novel and possibly modifiable risk factors for obesity in type 2 diabetes.

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.

Factors Identified to Predict Fatty Liver in Obese Teens

Factors Identified to Predict Fatty Liver in Obese Teens

Ethnicity,race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver.

Artificial Pancreas Treatment Efficacious for Type 1 Diabetes

Artificial Pancreas Treatment Efficacious for Type 1 Diabetes

For patients with type 1 diabetes, artificial pancreas treatment is efficacious, increasing the proportion of time spent in the near normoglycemic range.

HbA1c Variability Predicts All-Cause Mortality in Type 2 Diabetes

HbA1c Variability Predicts All-Cause Mortality in Type 2 Diabetes

HbA1c variability is a strong, independent predictor of all-cause mortality in patients with type 2 diabetes and appears to be more powerful than average HbA1c in predicting all-cause death.

Choroidal Thickness Changes in Patients With Untreated Diabetes

Choroidal Thickness Changes in Patients With Untreated Diabetes

Researchers examined the choroidal layer thickness in eyes of patients with diabetes to compare the findings based on medical history of systemic diabetes treatments and stage of diabetic retinopathy.

Pre-Pregnancy Fitness Lowers Gestational Diabetes Risk

Pre-Pregnancy Fitness Lowers Gestational Diabetes Risk

Researchers assessed the associations of pre-pregnancy fitness, moderate-to-vigorous-intensity physical activity, and time spent watching television on subsequent development of gestational diabetes.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-hour plasma glucose is a useful predictor of retinopathy risk, has a predictive value similar to that of 2-hour plasma glucose, and may be considered as an alternative glucose time point during an oral glucose tolerance test.

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Using both public and private health insurance claims data, investigators conducted a retrospective cohort study to assess cardiovascular risk in the setting of diabetes and rheumatoid arthritis.

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