The affordability and availability of diabetes medications across multiple regions of the word were examined, along with the effects on the use of medications.
Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.
Individuals with higher executive function performance at baseline experienced slower increases in HbA1c.
Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.
The sBLA includes results from the Phase 3 PANORAMA trial, which enrolled 402 patients with NPDR.
Investigators examined whether the use of glucagon-like peptide-1 receptor agonists is associated with an increased risk for incident diabetic retinopathy.
AHA, ADA, and Others Express Concern Around Proposed Legislation to Protect Those With Preexisting Conditions
The American Heart Association has published a statement in opposition of the latest Senate healthcare bill aimed at dismantling the Affordable Care Act.
Individuals with type 2 diabetes intensifying within 12 months of the index date had a significantly shorter median time from intensification to glycemic control.
Investigators assessed vaccination rates for hepatitis B vaccine series with electronic provider reminders in adults with diabetes.
Researchers concluded noninferiority between two basal insulin analogs after comparing safety and efficacy end points.
Investigators assessed the effect of complication burden and concurrent risk factors level on the risk of developing further microvascular complication.
The authors searched for randomized placebo-controlled trials (December 1, 2008 to November 24, 2017) involving 3 pharmacologic classes of antidiabetic medications to compare the effects of these agents on the risk of hospitalization for HF in T2DM patients.
Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.
Although the association between type 2 diabetes and schizophrenia is well established, the link between type 1 diabetes and schizophrenia is less clear.
Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.
Researchers conducted a retrospective analysis to determine whether second-line treatment options sulfonylureas, DPP-4 inhibitors, and thiazolidinediones were associated with reduced HbA1c levels.
Investigators aimed to assess the effect of psychotropic medications, BMI, duration of schizophrenia, number of hospitalizations, and physical activity on the risk for T2D.
Having high insulin at baseline was associated with a greater risk for incident diabetes mellitus compared with low insulin values.
Excess cardiovascular risk varies with age at diagnosis of type 1 diabetes.
Pharmacist roles include helping with insulin treatment, virtual consults, and diabetes management.
To determine the legacy effect of early glycemic control, researchers followed a cohort of 34,737 patients with newly diagnosed diabetes for an average of 13 years.
Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.
Diabetes and smoking are vascular risk factors associated with hippocampal calcification in older patients with memory issues.
The most prevalent complication was sexual dysfunction reported by both women and men, followed by urinary incontinence in women and low sexual desire in men.
WHO has developed guidelines for selecting therapy for treatment intensiﬁcation in type 2 diabetes and on the use of insulin in type 1 and 2 diabetes in resource-poor settings.
Investigators examined carotid plaque composition and remodeling using magnetic resonance imaging in patients who were diagnosed with type 2 diabetes for a short duration.
Investigators sought to determine whether participants who were followed-up before their diagnosis of diabetes had improved metabolic control afterward.
Significant improvement for older adults with depression, COPD; diabetes, cardiovascular disease.
Older adults who experience elevated depressive symptoms after being newly diagnosed with diabetes show a faster trajectory of disability.
First-trimester HbA1c significantly improves GDM prediction compared with conventional risk factors.
Researchers from the University of Southern California in Los Angeles examined the impacts of Medicaid expansion on access to diabetes medications.
The infection developed within several months of the patients starting SGLT2 therapy and the drug was discontinued in most cases. All patients required surgery and there was 1 reported death.
Investigators examined the excess risk for heart failure in patients with type 2 diabetes and compared the risk with that in the general population without diabetes.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.
Antipsychotic-treated patients with severe mental illnesses have a high prevalence of diabetes and prediabetes.
The PedsQL 3.2 can assist in identify new and existing therapeutic interventions for individuals with different diabetes-specific health-related quality of life profiles.
Investigators sought to determine whether excess risk factors for death and cardiovascular events in patients with type 2 diabetes could be reduced or eliminated.
While antipsychotic treatments can improve behavioral symptoms, risk of hyperglycemia and weight gain should inform careful consideration of antipsychotic use in young patients.
A low-energy diet for weight loss had different effects between men and women after weight reduction.
Among the many conditions that may co-occur with diabetes, eating disorders are common.
Investigators examine whether age of onset of type 1 diabetes affects mortality and cardiovascular risk.
In the absence of obesity, patients with PTSD are not at an increased risk for type 2 diabetes.
Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.
Recognizing the barriers to care for minority patients with type 2 diabetes could reduce the incidence of type 2 diabetes nationwide.
Investigators sought to compare cardiovascular risk and disease prevalence in the Hispanic and Latina population in the United States with and without a history of gestational diabetes.
Clinical Characteristics Altering Risks and Benefits of Sulfonylureas and Thiazolidinedione Therapy in T2D
Investigators examined patterns of benefits and risks associated between the sex and BMI of different patient subgroups and sulfonylurea and thiazolidinedione therapies.
But temporary increase in type 2 diabetes risk does not attenuate benefits on total, CVD mortality.
Clinical awareness of the bi-directional association may improve prevention and treatment of both diseases.
Investigators examined the effect of bariatric surgery and the incidence of microvascular complications in type 2 diabetes.
Maternal prepregnancy obesity without pregestational diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) was associated with a slightly increased risk of having a child with a neurodevelopmental or psychiatric disorder.
The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.
Investigators sought to determine the safety and efficacy of electroacupuncture for painful diabetic peripheral neuropathy.
Modifiable pregnancy and postpartum factors associated with at least 75% of weight loss in postpartum women with gestational diabetes have been examined.
Investigators sought to determine whether the use of dipeptidyl peptidase-4 inhibitors is associated with the incidence of rheumatoid arthritis.
Greater adherence to an overall healthy lifestyle is associated with a substantially lower risk for cardiovascular disease.
Compliance with general population guidelines for diabetes screening was suboptimal among patients with rheumatoid arthritis.
Antidiabetic agents for the treatment of diabetes including maintenance and max doses.
Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.
Investigators examined safety and efficacy of adjunct therapy to insulin for patients with type 1 diabetes who are not adequately controlled.
It is critical for us to remember that children are not little adults. Pediatric-onset diabetes is different from adult-onset diabetes due to its distinct epidemiology, pathophysiology, developmental considerations, and response to therapy.
High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents
The association between albumin-to-creatinine ratio and risk for diabetic nephropathy and CVD was examined over 2 to 4 years.
Sitagliptin May Improve Glycemic Control Better Than Dapagliflozin in T2D With Mild Renal Insufficiency
The safety and efficacy of sitagliptin vs dapagliflozin in patients with type 2 diabetes and renal insufficiency was examined.
Intermittent energy restriction diet may be an effective alternative diet strategy for reducing HbA1c in patients with type 2 diabetes.
The transition from pediatric to adult care for type 1 diabetes should be a gradual process, with a plan to make the change when the patient is ready, not at a pre-determined time.
Investigators assessed the effect of second-line therapies on weight, HbA1c, and treatment persistence over 18 months in patients who had received metformin monotherapy.
Uniform application of gestational diabetes diagnostic thresholds may not be appropriate in populations across the world.
Combination treatment with dapagliflozin plus omega-3 carboxylic acids may reduce fat content in nonalcoholic fatty liver disease.
More than 25 percent of older U.S. adults with diabetes use some type of complementary and alternative medicine.
A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators compared 2 interventions to reduce diabetes distress and improve glycemic control in patients with T1D.
Investigators examined cardiometabolic risk factor trajectories in patients diagnosed with type 2 diabetes over the course of 13 years preceding diabetic polyneuropathy.
Adolescent and young adult cancer survivors have a 73 percent higher risk of endocrine diseases.
Interruptions in private health insurance coverage are common among U.S. adults with type 1 diabetes and are associated with an increase in glycated hemoglobin and in use of acute care services.
Circulating hepatic markers may predict the risk for diabetes in women.
Investigators evaluate the performance of the G6 factory-calibrated continuous glucose monitoring system over 10 days.
For patients with asymptomatic left ventricular systolic dysfunction (ALVSD), those with diabetes have increased risk of heart failure development and hospitalization.
Partners of people with newly diagnosed diabetes have small but significant differences in health-related behavioral changes compared with partners of people without diabetes.
The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.
Comorbid depression, when not well controlled, can affect one's ability to self-manage diabetes. There can be loss of interest in making proper lifestyle choices, monitoring glucose levels, and taking one's medicines.
The new Flash Glucose Monitoring System enables patients to wear the sensor for up to 14 days compared with the existing FreeStyle Libre System that was approved for 10-day wear.
Investigators aim to identify risk factors for hippocampal calcifications and to investigate the relationship between hippocampal calcifications and cognitive function.
Ambulatory blood pressure monitoring in addition to office readings may effectively be able to identify individuals who are at high risk for CVD in T1D.
Investigators examined the effects of antithymocyte globulin with or without pegylated granulocyte colony-stimulating factor on β-cell function and HbA1C.
Investigators examined whether incretin-based therapies increase the risk for diabetic retinopathy compared with other antihyperglycemic agents.
Researchers assessed whether adding or switching to sulfonylureas is linked to increased risk for myocardial infarction, ischemic stroke, hypoglycemia, and all-cause mortality.
Results support that there is a relationship between diabetic retinopathy and Parkinson disease.
For patients with type 2 diabetes, characteristics of those with severe hypoglycemia include having a prior diagnosis of non-severe hypoglycemia and hemoglobin A1c (HbA1c) <6 percent.
Particulate matter (PM) with a diameter of less than 2.5 micrograms per cubic meter of air (PM2.5) makes a substantial contribution to the burden of diabetes.
A meta-analysis was conducted to examine the safety and efficacy of basal insulin analogs for type 2 diabetes.
In the AWARD-7 trial, patients who received Trulicity 0.75mg or 1.5mg in combination with mealtime insulin lispro achieved similar glycemic control with weight loss vs patients who received traditional basal-bolus insulin.
Results showed the overall safety profile of linagliptin in study patients, including adults with kidney disease, was consistent with previous data.
Adjustment of glucose-lowering medications in patients who are at high-risk for severe hypoglycemia may be beneficial to prevent mild cognitive impairment.
A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.
A team of Canadian researchers sought to determine if working at least 45 hours per week had an effect on the incidence of diabetes.
The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function.
A retrospective cohort study was conducted to assess the relationship between maternal diabetes and morbidity/mortality in preterm infants.
Popliteal Sciatic Nerve Block May Increase Time to First Opioid Request in Diabetic Peripheral Neuropathy
Patients with type 2 diabetes and diabetic peripheral neuropathy may have an increased time to first opioid request and reduced time to onset of sensory blockade after an ultrasound-guided popliteal sciatic nerve block compared with patients without neuropathy.
A retrospective, observational study was conducted to assess outcomes in patients with type 2 diabetes treated with second-generation basal insulin analogs.
For patients with type 2 diabetes mellitus (T2DM), travel costs relating to hemoglobin A1c (HbA1c) screening constitute a substantial cost item, and self-monitoring can reduce costs.
Endocrinology Advisor Articles
- Behavioral Weight Loss Interventions May Prevent Obesity
- Executive Function Predicts T1D Management Into Emerging Adulthood
- Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes
- Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D
- Rates of Incident Type 2 Diabetes in Chronic Kidney Disease
- Hypertension Treatments: ARBs
- Semaglutide vs Liraglutide for Weight Loss in Patients With Obesity
- Liraglutide May Lower Risk for Foot Amputation in Type 2 Diabetes
- Thyroid Hormone Levels, Body Composition, Insulin Resistance in Euthyroid Patients
- Executive Function Predicts T1D Management Into Emerging Adulthood
- How Personalized Hospital Ratings May Drive Patient-Specific Care in the Digital Age
- LVAD in Heart Failure Linked to Improved Glycemic Control
- Fundamental Institutional Change Is Needed to Eliminate Sexual Harassment
- Gestational Diabetes Tied to Subsequent Glucose Disorders
- Association Health Plans Can Help Small Businesses Offer Coverage