Diabetes Complications

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

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Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.

FDA to Review Eylea for the Treatment of Non-Proliferative Diabetic Retinopathy

FDA to Review Eylea for the Treatment of Non-Proliferative Diabetic Retinopathy

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The sBLA includes results from the Phase 3 PANORAMA trial, which enrolled 402 patients with NPDR.

Diabetic Retinopathy Risk Not Increased With GLP-1 Receptor Agonist Use in T2D

Diabetic Retinopathy Risk Not Increased With GLP-1 Receptor Agonist Use in T2D

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Investigators examined whether the use of glucagon-like peptide-1 receptor agonists is associated with an increased risk for incident diabetic retinopathy.

Concurrent Risk Factors and Microvascular Complications in Type 1 Diabetes

Concurrent Risk Factors and Microvascular Complications in Type 1 Diabetes

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Investigators assessed the effect of complication burden and concurrent risk factors level on the risk of developing further microvascular complication.

Bariatric Surgery Reduces Incidence of Microvascular Disease in Type 2 Diabetes

Bariatric Surgery Reduces Incidence of Microvascular Disease in Type 2 Diabetes

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Investigators examined the effect of bariatric surgery and the incidence of microvascular complications in type 2 diabetes.

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

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Investigators sought to determine the safety and efficacy of electroacupuncture for painful diabetic peripheral neuropathy.

Estimating Risk Factors and Trajectories for Diabetic Polyneuropathy

Estimating Risk Factors and Trajectories for Diabetic Polyneuropathy

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Investigators examined cardiometabolic risk factor trajectories in patients diagnosed with type 2 diabetes over the course of 13 years preceding diabetic polyneuropathy.

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

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A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.

Popliteal Sciatic Nerve Block May Increase Time to First Opioid Request in Diabetic Peripheral Neuropathy

Popliteal Sciatic Nerve Block May Increase Time to First Opioid Request in Diabetic Peripheral Neuropathy

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Patients with type 2 diabetes and diabetic peripheral neuropathy may have an increased time to first opioid request and reduced time to onset of sensory blockade after an ultrasound-guided popliteal sciatic nerve block compared with patients without neuropathy.

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

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ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

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A sustained-release formulation of sodium nitrite may not be associated with headaches and dizziness reported by patients treated with the immediate-release formulation of sodium nitrite for diabetic peripheral neuropathy.

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

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The paradoxical finding of accelerated wound healing and increase in HbA1c in participants with better baseline glycemic control requires confirmation in further studies.

High Risk of Death After Major Diabetes-Related Amputations

High Risk of Death After Major Diabetes-Related Amputations

There is a high risk of postoperative mortality among patients undergoing lower-limb amputation.

FDA Approves Unique Device for Diabetic Retinopathy Screening

FDA Approves Unique Device for Diabetic Retinopathy Screening

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This is the first device authorized for marketing that provides a screening decision without the need for clinician interpretation.

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

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Study provides stronger epidemiological evidence for obesity as a risk factor for diabetic polyneuropathy.

Repeated Ranibizumab Injections Does Not Impair Macular Perfusion

Repeated Ranibizumab Injections Does Not Impair Macular Perfusion

For patients with diabetic macular edema, repeated ranibizumab treatment does not appear to be associated with impaired macular perfusion.

Growth hormone-releasing hormone (GHRH) agonists protect against diabetic retinopathy in animal model

GHRH and GHRH receptor levels are decreased in diabetic rats and humans. Administration of GHRH agonists to diabetic rats reversed signs of diabetic retinopathy.

FDA Approves First Shock Wave Device for Treating Diabetic Foot Ulcers

FDA Approves First Shock Wave Device for Treating Diabetic Foot Ulcers

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The FDA has granted marketing clearance of the first shock wave device intended for use in the treatment of chronic, full-thickness diabetic foot ulcers.

Spinal Cord Stimulation Reduces Pain in Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain in Diabetic Polyneuropathy

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As many as one-quarter of individuals with diabetes will experience painful neuropathic symptoms for which treatment is limited.

Patients With Diabetic Retinopathy Experience Barriers to Diabetes Self-Management

Patients With Diabetic Retinopathy Experience Barriers to Diabetes Self-Management

Among Asians, individuals with mild and moderate diabetic retinopathy are more likely to have fallen, and greater perceived barriers to diabetes self-management are associated with the severity of DR in an Asian population.

Examining Melancholia and Atypical Depression in T1D and T2D

Examining Melancholia and Atypical Depression in T1D and T2D

Twenty-five percent of people with type 2 diabetes and 12% of people with type 1 diabetes had depression.

Insulin Pump Associated With Fewer Complications Than Injections in Children, Adolescents

Insulin Pump Associated With Fewer Complications Than Injections in Children, Adolescents

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Although the incidence of severe hypoglycemia has decreased while insulin pump use has increased, a causal relationship has not been established between insulin administration methods and risk of complications from diabetes.

Treatment Options for Diabetic Neuropathic Pain

Treatment Options for Diabetic Neuropathic Pain

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Painful diabetic neuropathy affects approximately one-quarter of people with diabetes.

Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers

Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers

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The efficacy and safety profile of hyperbaric oxygen therapy remains controversial because of conflicting data and small sample sizes in clinical trials.

Painful Diabetic Neuropathy: Challenges in Symptom Relief

Painful Diabetic Neuropathy: Challenges in Symptom Relief

A phase 2 clinical trial examined the efficacy of treating painful diabetic neuropathy (PDN) with filorexant, an orexin receptor antagonist.

Obstructive Sleep Apnea And Type 2 Diabetes: Complications and Treatments

Obstructive Sleep Apnea And Type 2 Diabetes: Complications and Treatments

Obstructive sleep apnea is associated with sight-threatening diabetic retinopathy in patients with type 2 diabetes.

Efficacy of Antimicrobial Treatments In Diabetic Foot Ulcers Examined

Efficacy of Antimicrobial Treatments In Diabetic Foot Ulcers Examined

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Researchers examined 22 randomized controlled trials to evaluate effects of various treatments on diabetic foot ulcers.

Eye Care in T1D: Guiding Retinopathy Screening Using HbA1c

Eye Care in T1D: Guiding Retinopathy Screening Using HbA1c

New recommendations suggest that frequency of diabetic retinopathy screening should be guided by patients' HbA1c levels.

Diabetic Ketoacidosis in Pregnancy May Lead to Fetal Death

Diabetic Ketoacidosis in Pregnancy May Lead to Fetal Death

Diabetic ketoacidosis led to fatal demise, preterm birth, and neonatal intensive care unit admissions.

Pooled Analysis Demonstrates Safety, Tolerability of Empagliflozin

Pooled Analysis Demonstrates Safety, Tolerability of Empagliflozin

A pooled analysis examined the rates of amputation and fracture in patients with type 2 diabetes prescribed empagliflozin.

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