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CYKLOKAPRON
Bleeding disorders
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Drug Name:

CYKLOKAPRON Rx

Generic Name and Formulations:
Tranexamic acid 100mg/mL; soln for IV inj.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CYKLOKAPRON:

Short-term use in hemophilia to reduce or prevent hemorrhage, and reduce the need for replacement therapy during and following tooth extraction.

Adults and Children:

Give by IV inj. Max injection rate: 1mL/min. Pre-extraction: 10mg/kg; post-op: 10mg/kg 3–4 times daily for 2–8 days. Renal impairment: serum creatinine 1.36–2.83mg/dL: 10mg/kg twice daily; 2.83–5.66mg/dL: 10mg/kg once daily; >5.66mg/dL: 10mg/kg every 48hrs or 5mg/kg every 24 hours.

Contraindications:

Acquired defective color vision. Subarachnoid hemorrhage. Active intravascular clotting.

Warnings/Precautions:

Therapy longer than several days: do ophthalmologic exam (before and during); discontinue if visual changes occur. Renal insufficiency; reduce dose. History of thromboembolic disease. Disseminated intravascular coagulation. Upper urinary tract bleeding. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Avoid concomitant Factor IX complex concentrates or Anti-inhibitor Coagulant concentrates; increased risk of thrombosis. Do not mix with solutions containing penicillin.

Pharmacological Class:

Plasminogen activation inhibitor.

Adverse Reactions:

GI upset, giddiness, hypotension, visual abnormalities; rare: thromboembolic events.

How Supplied:

Amps (10mL)—10

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