As a result of overlapping features with various other conditions, milder cases of Cushing's syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests.
The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.
Four-month-old developed iatrogenic Cushing's syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.
Guideline focuses on surgical resection to normalize cortisol levels.
The etiology of Cushing's syndrome affects how long it takes for a patient to recover their adrenal function after surgery.
Advances in genetics may hold the key to improving diagnosis and treatment of Cushing's syndrome, but issues still remain.
Adrenal insufficiency appears to impact patients differently and influences their beliefs about hydrocortisone replacement.
Patients with adrenal tumors of intermediate phenotype or subclinical Cushing's syndrome are at increased risk of cardiovascular events and mortality compared to those with stable non-secreting adrenal incidentalomas.
A mutation in the PRKACA gene appears to contribute to a rare but severe form of Cushing's syndrome.
Patients with Cushing's syndrome who were administered oral mifepristone (Korlym) daily experienced significant, sustained weight loss over the years as they continued on the medication.
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