Although patients reach clinical and biochemical remission, patients exposed to hypercortisolism do not show functional remission.
Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).
The treatment goals for Cushing syndrome are to normalize cortisol levels, reverse clinical symptoms, and if possible to remove the secreting neoplasm.
Study assessed cardiovascular function, quality of life, and mental/physical health in overt and cured Cushing syndrome.
As a result of overlapping features with various other conditions, milder cases of Cushing's syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests.
The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.
Four-month-old developed iatrogenic Cushing's syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.
Guideline focuses on surgical resection to normalize cortisol levels.
The etiology of Cushing's syndrome affects how long it takes for a patient to recover their adrenal function after surgery.
Advances in genetics may hold the key to improving diagnosis and treatment of Cushing's syndrome, but issues still remain.
Adrenal insufficiency appears to impact patients differently and influences their beliefs about hydrocortisone replacement.
Patients with adrenal tumors of intermediate phenotype or subclinical Cushing's syndrome are at increased risk of cardiovascular events and mortality compared to those with stable non-secreting adrenal incidentalomas.
A mutation in the PRKACA gene appears to contribute to a rare but severe form of Cushing's syndrome.
Patients with Cushing's syndrome who were administered oral mifepristone (Korlym) daily experienced significant, sustained weight loss over the years as they continued on the medication.
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- Cushing Syndrome Results in Poor Quality of Life Even After Remission