Hormone Replacement Therapies

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HORMONE REPLACEMENT THERAPIES
Generic Brand Form Strength Dosing
Frequency
ORAL ESTROGEN
conjugated estrogens Premarin tabs 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg, 2.5mg Once daily
esterified estrogens Menest tabs 0.3mg, 0.625mg, 1.25mg, 2.5mg
estradiol Femtrace tabs 0.9mg, 1.8mg
estradiol (micronized) Estrace tabs 0.5mg, 1mg, 2mg
estropipate Ogen tabs 0.625mg, 1.25mg, 2.5mg
Ortho-EST tabs 0.625mg, 1.25mg
synthetic conjugated estrogens, B Enjuvia tabs 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg
TRANSDERMAL ESTROGEN
estradiol Alora matrix patch 0.025mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day Twice weekly
Climara matrix patch 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day Once weekly
Divigel topical gel 0.25mg/pkt, 0.5mg/pkt, 1mg/pkt Once daily
Elestrin topical gel 0.87g/pump Once daily
Estraderm reservoir patch 0.05mg/day, 0.1mg/day Twice weekly
Estrasorb topical emulsion 1.74g/pouch 2 pouches once daily
Estrogel topical gel 1.25g/pump 1 pump once daily
Evamist topical spray 1.53mg/spray Initially 1 spray daily; may increase to 2−3 sprays if needed
Menostar matrix patch 0.014mg/day Once weekly
Minivelle patch 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day Twice weekly
Vivelle matrix patch 0.05mg/day, 0.1mg/day Twice weekly
Vivelle-Dot matrix patch 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day Twice weekly
VAGINAL ESTROGEN
conjugated estrogens Premarin cream 0.625mg/g Daily
estradiol Estring ring 7.5mcg/24hrs Once every 90 days
Femring ring 0.05mg/day, 0.1mg/day Once every 3mos
Vagifem vaginal inserts 10mcg Once daily for 2wks, then twice weekly
ORAL ESTROGEN + ESTROGEN AGONIST/ANTAGONIST
conjugated estrogens/
bazedoxifene
Duavee tabs 0.45mg/20mg Once daily
ORAL PROGESTOGEN
MPA Provera tabs 2.5mg, 5mg, 10mg Once daily
norethindrone acetate Aygestin tabs 5mg
progesterone (micronized) Prometrium caps 100mg, 200mg
ORAL ESTROGEN + PROGESTOGEN
conjugated estrogens (14 tabs); then conjugated estrogens/
MPA (14 tabs)
Premphase tabs 0.625mg; then 0.625mg/5mg Once daily, sequentially
conjugated estrogens/
MPA (28 tabs)
Prempro tabs 0.3mg/1.5mg, 0.45mg/1.5mg,
0.625mg/
 
2.5mg, 0.625mg/5mg
Once daily, continuously
estradiol (3 tabs); then estradiol/
norgestimate (3 tabs)
Prefest tabs 1mg; then 1mg/0.09mg Once daily, sequentially
estradiol/
drospirenone
Angeliq tabs 0.5mg/0.25mg, 1mg/0.5mg Once daily
estradiol/
norethindrone acetate
Activella tabs 0.5mg/0.1mg, 1mg/0.5mg Once daily
norethindrone acetate/
ethinyl estradiol
Femhrt tabs 0.5mg/2.5mcg, 1mg/5mcg Once daily, continuously
Note: Progestin listed first
TRANSDERMAL ESTROGEN + PROGESTOGEN
estradiol/
levonorgestrel
Climara Pro matrix patch 0.045mg/
 
0.015mg per
 
day
Once weekly
estradiol/
norethindrone acetate
Combipatch matrix patch 0.05mg/
 
0.14mg per
 
day,
0.05mg/
 
0.25mg per
 
day
Twice weekly
NOTES

Key:  MPA = medroxyprogesterone acetate.
Matrix patch: Estradiol is embedded in the adhesive layer that is applied directly to the skin.
Reservoir patch: Estradiol is contained in a drug reservoir and its release is controlled by a copolymer membrane; contains more layers than matrix patch.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Estrogen component is listed first for combination products. Listed strengths are not necessarily the same as the dosage. Listed dosing frequency is for use in HRT; may be other frequencies for other uses. Some products are given cyclically.

(Rev. 7/2017)

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