Moderate Red Wine Intake May Decrease Cardiometabolic Risk in Type 2 Diabetes

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Moderate consumption of red wine appeared to decrease cardiometabolic risks in diabetes.
Moderate consumption of red wine appeared to decrease cardiometabolic risks in diabetes.

(HealthDay News) — Moderate red wine intake is safe and modestly decreases cardiometabolic risk among patients with well-controlled diabetes following the Mediterranean diet, according to a study published in the Annals of Internal Medicine.

Yftach Gepner, MPH, from Ben-Gurion University in Israel, and colleagues randomly assigned patients 150 mL of mineral water, white wine, or red wine with dinner for 2 years. All patients followed a Mediterranean diet without caloric restriction, and of the 224 who initially participated, 94% had 1-year follow-up data and 87% had 2-year follow-up data.

The researchers found that red wine significantly increased the HDL cholesterol level by 0.05 mmol/L (P<.001) and apolipoprotein(a)1 level by 0.03 g/L (P=.05) and decreased the total cholesterol/HDL cholesterol ratio by 0.27 (P=.039). 

A significant benefit from both wines on glycemic control (fasting plasma glucose, homeostatic model assessment of insulin resistance, and HbA1c), was seen only in slow ethanol metabolizers (alcohol dehydrogenase alleles [ADH1B*1] carriers) compared with fast ethanol metabolizers (persons homozygous for ADH1B*2). 

Compared with water, red wine further significantly reduced the number of components of metabolic syndrome (P=.049).

"The genetic interactions suggest that ethanol plays an important role in glucose metabolism, and red wine's effects also involve nonalcoholic constituents," the researchers wrote.

Reference

  1. Gepner Y, Golan R, Harman-Boehm I, et al. Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial. Ann Intern Med. 2015;doi:10.7326/M14-1650.
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