Omega-3 Fatty Acids May Be Beneficial After Acute Myocardial Infarction

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High doses of omega-3 fatty acids improved heart function in patients after acute myocardial infarction.
High doses of omega-3 fatty acids improved heart function in patients after acute myocardial infarction.

(HealthDay News) — Acute myocardial infarction (MI) patients who take high doses of omega-3 fatty acids for 6 months show improved heart function and less scarring, according to a study published in Circulation.

Raymond Kwong, MD, director of cardiac magnetic resonance imaging at Brigham and Women's Hospital in Boston, and colleagues followed 358 acute MI survivors for 6 months. Half of them were given 4 g of omega-3 fatty acid supplements daily for 6 months, while the other half were given placebo.

Using cardiac magnetic resonance imaging, the researchers found there was a 6% improvement in both left ventricular systolic volume index (5.8%) and noninfarct myocardial fibrosis (5.6%) among patients who took 4 g of omega-3 fatty acids daily. Patients in the omega-3 fatty acid arm also showed significant reductions in serum biomarkers of systemic and vascular inflammation.

"Treatment of patients with acute MI with high-dose omega-3 fatty acids was associated with reduction of adverse left ventricular remodeling, noninfarct myocardial fibrosis, and serum biomarkers of systemic inflammation beyond current guideline-based standard of care," the researchers wrote.

Reference

  1. Heydari B, Abdullah S, Pottala JV, et al. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial. Circulation. 2016. doi:10.1161/CIRCULATIONAHA.115.019949.
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