Metabolic Syndrome, Obesity Increase Mortality Risk in Colorectal Cancer
Metabolic syndrome and obesity increase the risk for all-cause and colorectal cancer-related death.
HealthDay News -- For patients with early-stage colorectal cancer, the presence of metabolic syndrome and obesity is associated with increased risk of mortality, according to a study published online September 6 in the Journal of Clinical Oncology.
Elizabeth M. Cespedes Feliciano, ScD, from Kaiser Permanente Northern California in Oakland, and colleagues studied 2446 patients with early-stage colorectal cancer diagnosed from 2006 to 2011. Participants were classified according to the presence or absence of metabolic syndrome and obesity.
The researchers found that 601 patients died over a median follow-up of 6 years, 325 as a result of colorectal cancer. For overall survival the hazard ratios (HRs) were 1.45 for obese patients with metabolic syndrome (95% CI, 1.12-1.82); 1.09 for nonobese with metabolic syndrome (95% CI, 0.83-1.44); and 1.00 for obese patients without metabolic syndrome (95% CI, 0.80-1.26), compared with nonobese patients without metabolic syndrome. Colorectal cancer-related survival was predicted by obesity with metabolic syndrome (HR, 1.49; 95% CI, 1.09-2.02). There was an increase in the risk of death with the number of metabolic syndrome components present, which was independent of obesity.
"Patients with early-stage colorectal cancer with obesity and metabolic syndrome have worse survival, overall and colorectal cancer-related," the researchers wrote.
Disclosures: Two authors disclosed financial ties to the biopharmaceutical industry.