Metabolic Syndrome, Obesity Increase Mortality Risk in Colorectal Cancer

Share this content:
Metabolic syndrome and obesity increase the risk for all-cause and colorectal cancer-related death.
Metabolic syndrome and obesity increase the risk for all-cause and colorectal cancer-related death.

HealthDay News -- For patients with early-stage colorectal cancer, the presence of metabolic syndrome and obesity is associated with increased risk of mortality, according to a study published online September 6 in the Journal of Clinical Oncology.

Elizabeth M. Cespedes Feliciano, ScD, from Kaiser Permanente Northern California in Oakland, and colleagues studied 2446 patients with early-stage colorectal cancer diagnosed from 2006 to 2011. Participants were classified according to the presence or absence of metabolic syndrome and obesity.

The researchers found that 601 patients died over a median follow-up of 6 years, 325 as a result of colorectal cancer. For overall survival the hazard ratios (HRs) were 1.45 for obese patients with metabolic syndrome (95% CI, 1.12-1.82); 1.09 for nonobese with metabolic syndrome (95% CI, 0.83-1.44); and 1.00 for obese patients without metabolic syndrome (95% CI, 0.80-1.26), compared with nonobese patients without metabolic syndrome. Colorectal cancer-related survival was predicted by obesity with metabolic syndrome (HR, 1.49; 95% CI, 1.09-2.02). There was an increase in the risk of death with the number of metabolic syndrome components present, which was independent of obesity.

"Patients with early-stage colorectal cancer with obesity and metabolic syndrome have worse survival, overall and colorectal cancer-related," the researchers wrote.

Disclosures: Two authors disclosed financial ties to the biopharmaceutical industry.


  1. Cespedes Feliciano EM, Kroenke CH, Meyerhardt JA, et al. Metabolic dysfunction, obesity, and survival among patients with early-stage colorectal cancer. J Clin Oncol. 2016. doi:10.1200/JCO.2016.67.4473.
You must be a registered member of Endocrinology Advisor to post a comment.

Sign Up for Free e-Newsletters

CME Focus